Tarţӑu, Liliana; Andriţoiu, Cӑlin; Teslariu, Elena; Dima, Corina; Şindrilar, Eusebiu Viorel
September 2009
Therapeutics, Pharmacology & Clinical Toxicology;2009, Vol. 13 Issue 3, p27
Academic Journal
Aim. Experimental researches on the effects of a selective k opioid receptor agonist in cutaneous and visceral pain models in mice. Material and method The experiments were carried out on white Swiss mice (20-25g), divided into 4 groups of 7 animals each, treated intraperitoneally with the same volume of solution, as follows: Group I: distilled water (Control) 0,3ml; Group II (U-50488H 10): U-50488H 10mg/kbw; Group III (U-50488H 20): U-50488H 20mg/kbw; Group IV (MOR): morphine 2mg/ kbw. Experimental protocols were implemented in accordance to the recommendations of the committee of research and ethics of the International Association for the Study of Pain. The nociceptive cutaneous testing was performed using the tail flick assay. The model of visceral pain consisted of inflammatory cystitis after intraperitoneal injection of cyclophosphamide (200 mg/kbw). The data were presented as +/- SD and significance was tested by SPSS for Windows version 13.0 and by the ANOVA method, followed by the Neumann Keuls test as post hoc. Results and conclusions. In our experimental conditions, U50,488H (10mg/kbw) determined antinociceptive significant effects in tail flick test, 30 minutes after thermal noxious stimulation, but did not influence visceral nociceptive responses in cyclophosphamide-induced cystitis. Intraperitonal administration of selective k opioid agonist U50,488H, 20mg/kbw, resulted in a potent analgesia in both cutaneous and visceral pain models.


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