TITLE

EXPERIMENTAL STUDY ON THE ANALGESIC EFFECT OF DIMETHYLSULFOXIDE IN MICE USING THE WRITHING TEST

AUTHOR(S)
Paunescu, H.; Coman, Oana Andreia; Panaitescu, Eugenia; Anca, Andreea; Ghiţӑ, Isabel; Fulga, I.
PUB. DATE
September 2009
SOURCE
Therapeutics, Pharmacology & Clinical Toxicology;2009, Vol. 13 Issue 3, p270
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction. DMSO (dimethylsulfoxide) is frequently used in fundamental pharmacology as solvent for different organic compounds, due to its amphipathic molecule, which is soluble in both aqueous and nonpolar, organic media. Aim. In the present experiment we tried to explore if DMSO has an analgesic effect per se in the writhing test, pure or diluted 1:1 in saline. If so, the question remains if it can be used with out any problem as vehicle for nonpolar substances with a possible visceral analgesic effect. Materials and methods. Five groups of albino mice were tested with DMSO, pure or diluted in saline 1:1 vol/vol, metamizole sodium+saline and metamizole sodium+DMSO diluted in saline 1:1 vol/vol. The writhing test was performed 120 min after substances administration and the observation of writhes lasted for 5 minutes. Statistic analysis of data was made with the programs Excel and SPSS 15. Results and discussions. A statistically significant difference between the tested groups was obtained using a nonparametric statistic test (Kruskal Wallis). DMSO pure had a significant analgesic effect, while DMSO diluted 1:1 in saline did not. DMSO associated to metamizole sodium had a nonsignificant tendency to increase the analgesic effect of metamizole sodium in the writhing test. Conclusions. These results raise the question of a possible interference of DMSO, used as vehicle, on the analgesic effects of other substances assayed in the writhing test.
ACCESSION #
50339691

 

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