TITLE

INVESTIGATION OF CORRELATION STRESS HYPERHOMOCYSTEINEMIA, IN RATS

AUTHOR(S)
Albu, E.; Filip, C.; Zamosteanu, N.; Dimitriu, D. C.; Jaba, I. M.; Gheorghit, N.; Jerca, L.; Mingiu, O. C.
PUB. DATE
September 2009
SOURCE
Therapeutics, Pharmacology & Clinical Toxicology;2009, Vol. 13 Issue 3, p261
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Today it is generally accepted that the so called "stress" plays an important role in the process of aging. The main mechanism through which stress is involved in the aging process seems to be represented by reactive species generation. On the other hand, hyperhomocysteinemia, a risk factor in cardiovascular diseases, disturbs the normal endothelium functions and generates thrombosis through a mechanism in which reactive species seem to be also involved. In our work, we have studied the influence of stress and hyperhomocysteinemia on antioxidant intraand extracellular systems, in order to establish if there is a cumulative effect of these two parameters, in rats. Experimental stress was induced by reversing the normal cycle day/night (1800 - 600 light) at the animals of experience for a 15 days period. Experimental hyperhomocisteinemia was induced by oral administration of methionine 2g/kg body weight, single dose daily, for a 15 days period. The activities of intracellular superoxide dismutase (SOD), glutathione peroxidase (GPx) and plasma total antioxidant status (TAS) were measured using Randox kit for manual use. The plasmatic concentrations of homocysteine were measured using a Roche standardized kit Diazyme. Our data show an increase in SOD activity, simultaneously withthe decrease of GPx activity. The total antioxidant status and homocysteine levels have no significant changed. In conclusion, subacute stress activates the antioxidant defense systems but doesn't influence the total antioxidant capacity and homocysteine levels, in rats.
ACCESSION #
50339689

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics