Implementation of Discrete Element Analysis for Subject-Specific, Population-Wide Investigations of Habitual Contact Stress Exposure

Anderson, Donald D.; Iyer, Krishna S.; Segal, Neil A.; Lynch, John A.; Brown, Thomas D.
May 2010
Journal of Applied Biomechanics;May2010, Vol. 26 Issue 2, p215
Academic Journal
There exist no large-series human data linking contact stress exposure to an articular joint's propensity for developing osteoarthritis because contact stress analysis for large numbers of subjects remains impractical. The speed and simplicity of discrete element analysis (DEA) for estimating contact stresses makes its application to this problem highly attractive, but to date DEA has been used to study only a small numbers of cases. This is because substantial issues regarding its use in population-wide studies have not been addressed. Chief among them are developing fast and robust methods for model derivation and the selection of boundary conditions, establishing accuracy of computed contact stresses, and including capabilities for modeling in-series structural elements (e.g., a meniscus). This article describes an implementation of DEA that makes it feasible to perform subject-specific modeling in articular joints in large population-based studies.


Related Articles

  • Whatever became of...  // Arthritis Today;Mar/Apr97, Vol. 11 Issue 2, p14 

    Presents updates on cartilage study for joint damage repair caused by osteoarthritis, published in the May-June 1987 issue of `Arthritis Today' periodical. Research on the isolation of an enzyme called aggrecanase, responsible for breaking down cartilage component proteoglycan; Focus on the...

  • Joint Injuries Can Lead to Osteoarthritis.  // Tufts University Health & Nutrition Letter;Dec2000, Vol. 18 Issue 10, p2 

    Suggests that joint injuries in early years may cause osteoarthritis in the old age. Account of a related study.

  • EFFECT OF CAPSULAR INJURY ON ACROMIOCLAVICULAR JOINT MECHANICS. Debski, Richard E.; Parsons, I.M.; Woo, Savio L-Y.; Fu, Freddie H. // Journal of Bone & Joint Surgery, American Volume;Sep2001, Vol. 83-A Issue 9, p1344 

    Background: Traumatic disruption of the acromioclavicular joint capsule is associated with pain and instability after the injury and may lead to degenerative joint disease. The objective of this study was to quantify the effect of transection of the acromioclavicular joint capsule on the...

  • Analysis of the Relationship between Peak Stress and Proteoglycan Loss following Injurious Compression of Human Post-mortem Knee and Ankle Cartilage. Debbie Cheng; Ada Cole; Klaus Kuettner // Biomechanics & Modeling in Mechanobiology;Jan2007, Vol. 6 Issue 1, p83 

    Abstract??While traumatic joint injuries are known to increase the risk of osteoarthritis (OA), the mechanism is not known. Models for injurious compression of cartilage may identify predictors of injury that suggest a clinical mechanism. We investigated the relationship between peak stress...

  • Fatigue is More Damaging than Creep in Ligament Revealed by Modulus Reduction and Residual Strength. Timothy D. Schwab; Thomas R. Oxland // Annals of Biomedical Engineering;Oct2007, Vol. 35 Issue 10, p1713 

    Abstract  Following injury of a complementary joint restraint, ligaments can be subjected to higher than normal stresses. Normal ligaments are exposed to static (creep) and cyclic (fatigue) loading from which damage can accumulate at these higher than normal stresses. This study...

  • Obesity & osteoarthritis. King, Lauren K.; March, Lyn; Anandacoomarasamy, Ananthila // Indian Journal of Medical Research;Aug2013, Vol. 138 Issue 2, p185 

    The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degeneratis e joint disorder characterized by pain, decreased mobility and negative impact on quality of life. OA pathogenesis relates to both excessive joint loading and...

  • A 57-Year-Old Man With Osteoarthritis of the Knee. Lonner, Jess H. // JAMA: Journal of the American Medical Association;2/26/2003, Vol. 289 Issue 8, p1016 

    Presents observations about a man with osteoarthritis of the knee. How the patient is a long-distance bicyclist; Consideration of a moderate effusion to the knee and a palpable semi-membranous bursa; Proposal of knee surgery; Development of progressive joint stiffness and contracture from...

  • Treatment of distal radioulnar joint disorders with a modified Sauvé-Kapandji procedure: long-term outcome with special attention to the DASH Questionnaire. Zimmermann, Robert; Gschwentner, Martin; Arora, Rohit; Harpf, Christoph; Gabl, Markus; Pechlaner, Sigurd // Archives of Orthopaedic & Trauma Surgery;Jul2003, Vol. 123 Issue 6, p293 

    Introduction. An intact distal radioulnar joint (DRUJ) is essential for normal functioning of the upper limb. Osteoarthritis of the DRUJ often leads to ulnar wrist pain, limitation of forearm rotation and reduced grip strength, all of which limit activities of daily living. Once the joint is...

  • A Novel Dynamic Ankle-Supinating Device. Gutierrez, Gregory M.; Kaminski, Thomas // Journal of Applied Biomechanics;Feb2010, Vol. 26 Issue 1, p114 

    Lateral ankle sprains (LAS) are among the most common joint injuries, and although most are resolved with conservative treatment, others develop chronic ankle instability (AI). Considerable attention has been directed toward understanding the underlying causes of this pathology; however, little...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics