Differences in the Salivary Glycan Pattern between Children with High and Low Caries Susceptibility

Seemann, R.; Zimmer, S.; Bizhang, M.; Kage, A.
March 2001
Caries Research;Mar/Apr2001, Vol. 35 Issue 2, p156
Academic Journal
Interactions between bacterial adhesins of lectin type and the oligosaccharide part of immobilised glycoconjugates on the tooth surface are involved in the specific colonisation of teeth. The specificity of the adhesion process is determined by the carbohydrate specificity of the bacterial lectins and the availability of the corresponding glycosylation pattern. On the other hand the same carbohydrate structures can specifically prevent the binding of bacteria by competitively blocking their adhesion, if sufficient amounts of this distinct carbohydrate structure are available in the secretion. Since carbohydrate binding receptors are also involved in the colonisation of tooth surfaces by cariogenic bacteria, it has been suggested that the architecture of the oligosaccharide portion of soluble glycoconjugates in saliva may play an important role as a constitutional host defence factor in the aetiology of dental caries. Characterising the availability of distinct carbohydrate patterns in saliva by using a pattern of well-described lectins in a competitive lectin inhibition assay we show that in children of a population-based sample a high caries susceptibility is associated with a reduced binding inhibition against the lectin peanut agglutinin (PNA). PNA is specific for the presence of terminal galactosyl residues and binds to the same O-glycan fractions as a surface lectin from Streptococcus mutans. The data suggest that a reduced availability of glycosylation patterns of galactosyl residues detected by the lectin PNA may act as an additional host-derived factor for an increased caries susceptibility.


Related Articles

  • Genetic profiling to combat childhood dental decay.  // British Dental Journal;2/24/2007, Vol. 202 Issue 4, p180 

    The article cites a study published in the "Journal of Clinical Microbiology" regarding a genetic profiling method to fight dental decay in children. Researchers collected plaque samples from children, some with severe early-childhood caries (S-CCC) and some caries-free (CF). Using denaturing...

  • Detection of Approximal Caries in 5-Year-Old Swedish Children. Anderson, M.; Stecksén-Blicks, C.; Stenlund, H.; Ranggård, L.; Tsilingaridis, G.; Mejàre, I. // Caries Research;Mar/Apr2005, Vol. 39 Issue 2, p92 

    The aim was to assess how accurately some commonly used risk factors/risk markers (predictors) for caries development could identify children with and without approximal caries as judged from bitewing radiography. Two hundred and sixty-seven consecutive 5-year-old children from two Swedish...

  • Early Childhood Caries Prevalence, Severity and Pattern in 3-6 Year Old Preschool Children of Mysore City, Karnataka. AGARWAL, Deepti; Sunitha, S.; REDDY, C. V. K.; MACHALE, Priyanka // Pesquisa Brasileira em Odontopediatria e Clinica Integrada;out-dez2012, Vol. 12 Issue 4, p561 

    Objective: To determine Early Childhood Caries (ECC) prevalence, severity and pattern in preschool children of Mysore City, Karnataka. Methods: A total of 10 preschools, five government and five private were selected randomly from 5 different sectors in Mysore. A total of 500 children and their...

  • Clinical Guideline on Periodicity of Examination, Preventive Dental Services, Anticipatory Guidance, and Oral Treatment for Children.  // Pediatric Dentistry;Reference Manual 2003-2004, Vol. 25 Issue 7, p61 

    This article presents the American Academy of Pediatric Dentistry (AAPD) guideline for periodicity of examination, preventive dental services, anticipatory guidance, and oral treatment for children to help dentists make clinical decisions for such treatments.

  • Clinical Guideline on Adolescent Oral Health Care.  // Pediatric Dentistry;Reference Manual 2003-2004, Vol. 25 Issue 7, p55 

    This article presents the American Academy of Pediatric Dentistry (AAPD) guideline for oral health care for adolescents. The AAPD has determined that long-term oral health care is more likely if the oral health care for adolescents is managed by pediatric dentists.

  • Spreading the Message on Childhood Caries. Stymiest, Deborah // Journal of the Canadian Dental Association;Dec2008/Jan2009, Vol. 74 Issue 10, p851 

    The author reflects on the need to refocus efforts on disseminating message of dental decay prevention among children in Canada. She remarks that in a prosperous country like Canada, adequate dental care should be a priority and available to all children. She contends that dental experts should...

  • A survey of pediatric dentists' management of dental caries in children three years of age or younger. Seale, N. Sue; Kendrick, Alice G. // Pediatric Dentistry;May/Jun2001, Vol. 23 Issue 3, p211 

    Purpose: The purpose of this study was to report the results of a survey of pediatric dentistry post-doctoral program directors regarding education of post-doctoral students about management of caries in children 3 years-of-age or younger. Methods: Fifty-two pediatric dentistry advanced...

  • Early childhood caries (ECC): unique challenge and treatment options.  // Pediatric Dentistry;Reference Manual 2002-2003, Vol. 24 Issue 7, p24 

    The article focuses on the American Academy of Pediatric Dentistry's (AAPD) policy on early childhood caries (ECC). It notes that AAPD encourages quality and appropriate oral health care for children with early childhood caries through the education of the health community and society about the...

  • Changing trend of caries from 1989 to 2004 among 12-year old Sardinian children. Campus, Guglielmo; Sacco, Gianluca; Cagetti, MariaGrazia; Abati, Silvio // BMC Public Health;2007, Vol. 7 Issue 1, p28 

    Background: During the past decades, the prevalence of caries disease in the population of Western industrialized countries has decreased markedly. In children also, a reduction of dental caries experience has been reported by many authors. The aim of this paper was to evaluate the trend of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics