TITLE

Effect of Pioglitazone -- on Energy Intake and Ghrelin in Diabetic Patients

AUTHOR(S)
Martin, Corby K.; Gupta, Alok K.; Smith, Steven R.; Greenway, Frank L.; Han, Hongmei; Bray, George A.
PUB. DATE
April 2010
SOURCE
Diabetes Care;Apr2010, Vol. 33 Issue 4, p742
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE -- To measure ghrelin and energy intake in the laboratory after pioglitazone treatment. RESEARCH DESIGN AND METHODS -- This was a parallel, three-arm study with 51 obese diabetic subjects randomized to either 1) pioglitazone plus a portion-controlled diet (Pio+PC), 2) pioglitazone plus American Diabetes Association (ADA) dietary advice (Pio+ADA), or 3) metformin plus ADA advice (Met+ADA). Energy intake and the suppressive response of a meal on ghrelin were measured at weeks 0 and 16. Mixed models tested if changes from week 0 to 16 differed by group. RESULTS -- The Pio+ADA group had a significantly larger increase (P < 0.05) in energy intake ([adjusted means ± SE] 207 ± 53 kcal) compared with the Pio+PC (50 ± 46 kcal) and Met+ADA (52 ± 49 kcal) groups. Change in restraint and disinhibition (variables associated with eating behavior) mediated weight change. Ghrelin suppression increased in the Pio +ADA group, which gained weight. CONCLUSIONS -- A portion-controlled diet attenuated the increase in energy intake after pioglitazone. Ghrelin responded to weight change not pioglitazone exposure.
ACCESSION #
50285327

 

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