Central blood pressure and pulse wave velocity: relationship to target organ damage and cardiovascular morbidity-mortality in diabetic patients or metabolic syndrome. An observational prospective study. LOD-DIABETES study protocol

Gómez-Marcos, Manuel A.; Recio-Rodríguez, José I.; Rodríguez-Sánchez, Emiliano; Castaño-Sánchez, Yolanda; Cabo-Laso, Angela de; Sánchez-Salgado, Benigna; Rodríguez-Martín, Carmela; Castaño-Sánchez, Carmen; Gómez-Sánchez, Leticia; García-Ortiz, Luis
January 2010
BMC Public Health;2010, Vol. 10 Issue 1, p143
Academic Journal
Background: Diabetic patients show an increased prevalence of non-dipping arterial pressure pattern, target organ damage and elevated arterial stiffness. These alterations are associated with increased cardiovascular risk. The objectives of this study are the following: to evaluate the prognostic value of central arterial pressure and pulse wave velocity in relation to the incidence and outcome of target organ damage and the appearance of cardiovascular episodes (cardiovascular mortality, myocardial infarction, chest pain and stroke) in patients with type 2 diabetes mellitus or metabolic syndrome. Methods/Design: Design: This is an observational prospective study with 5 years duration, of which the first year corresponds to patient inclusion and initial evaluation, and the remaining four years to follow-up. Setting: The study will be carried out in the urban primary care setting. Study population: Consecutive sampling will be used to include patients diagnosed with type 2 diabetes between 20-80 years of age. A total of 110 patients meeting all the inclusion criteria and none of the exclusion criteria will be included. Measurements: Patient age and sex, family and personal history of cardiovascular disease, and cardiovascular risk factors. Height, weight, heart rate and abdominal circumference. Laboratory tests: hemoglobin, lipid profile, creatinine, microalbuminuria, glomerular filtration rate, blood glucose, glycosylated hemoglobin, blood insulin, fibrinogen and high sensitivity C-reactive protein. Clinical and 24-hour ambulatory (home) blood pressure monitoring and selfmeasured blood pressure. Common carotid artery ultrasound for the determination of mean carotid intima-media thickness. Electrocardiogram for assessing left ventricular hypertrophy. Ankle-brachial index. Retinal vascular study based on funduscopy with non-mydriatic retinography and evaluation of pulse wave morphology and pulse wave velocity using the SphygmoCor system. The medication used for diabetes, arterial hypertension and hyperlipidemia will be registered, together with antiplatelet drugs. Discussion: The results of this study will help to know and quantify the prognostic value of central arterial pressure and pulse wave velocity in relation to the evolution of the subclinical target organ damage markers and the possible incidence of cardiovascular events in patients with type 2 diabetes mellitus. Trial Registration: ClinicalTrials.gov Identifier: NCT01065155


Related Articles

  • Increased augmentation of central blood pressure is associated with increases in carotid intima—media thickness in type 2 diabetic patients. Westerbacka, J.; Leinonen, E.; Salonen, J. T.; Salonen, R.; Hiukka, A.; Yki-Järvinen, H.; Taskinen, M.-R. // Diabetologia;Aug2005, Vol. 48 Issue 8, p1654 

    Aims/hypothesis: Type 2 diabetes is associated with a two- to seven-fold increase in cardiovascular morbidity and mortality. The aim of this study was to determine the relationships between intima-media thickness (IMT), an established marker of atherosclerosis, large artery function and other...

  • The major determinants of arterial stiffness in Korean patients with rheumatoid arthritis are age and systolic blood pressure, not disease-related factors. Kim, Young-Sam; Sung, Yoon-Kyoung; Choi, Chan-Bum; Uhm, Wan-Sik; Kim, Tae-Hwan; Shin, Jin-Ho; Jun, Jae-Bum // Rheumatology International;Nov2012, Vol. 32 Issue 11, p3455 

    Patients with rheumatoid arthritis are at increased risk of cardiovascular morbidity and mortality. This study was undertaken to investigate the prevalence of peripheral arterial disease, and to identify factors, especially those related to rheumatoid arthritis, influencing arterial stiffness in...

  • Measurement of Arterial Pressure Waves and Central Blood Pressure: Opportunities and Challenges. Kotchen, Theodore A. // American Journal of Hypertension;Sep2015, Vol. 28 Issue 9, p1075 

    The article presents the author's views on opportunities and challenges in measurement of arterial blood pressure. Topics discussed include predictions of cardiovascular risks through measurement of central blood pressure (CBP), impact of aging on arterial stiffness and variable effects produced...

  • GP Business: Hypertension - part two. Newson, Louise // GP: General Practitioner;6/21/2004, p49 

    The latest British Hypertension Society guidelines are similar in many respects to the previous guidelines. They align with European Society guidelines for the classification of hypertension. Mild disease is defined as a blood pressure of 140-159/90-99 mmHg, moderate hypertension as...

  • Association of Plasma Pentraxin 3 With Arterial Stiffness in Overweight and Obese Individuals. Miyaki, Asako; Maeda, Seiji; Choi, Youngju; Akazawa, Nobuhiko; Eto, Miki; Tanaka, Kiyoji; Ajisaka, Ryuichi // American Journal of Hypertension;Oct2013, Vol. 26 Issue 10, p1250 

    BACKGROUND Obesity and increased arterial stiffness are independent risk factors for cardiovascular disease. The degree of arterial stiffness in obese individuals is greater than that in normal-weight subjects. Pentraxin 3 (PTX3) is mainly produced by vascular tissues and exerts a...

  • Arterial stiffness is increased in asthmatic children. Steinmann, Markus; Abbas, Chiara; Singer, Florian; Casaulta, Carmen; Regamey, Nicolas; Haffner, Dieter; Fischer, Dagmar-Christiane; Simonetti, Giacomo // European Journal of Pediatrics;Apr2015, Vol. 174 Issue 4, p519 

    Altered arterial stiffness is a recognized risk factor of poor cardiovascular health. Chronic inflammation may increase arterial stiffness. We tested whether arterial stiffness is increased children with asthma, a chronic disease characterized by fluctuating airway and systemic inflammation....

  • Arterial stiffness in correlation with cardiovascular risk factors in hypertensive patients (population study). Bastrikov, O. Yu.; Grigoricheva, E. A.; Belov, V. V. // Regional Haemodynamics & Microcirculation;2014, Vol. 13 Issue 3, p17 

    Purpose. To study the parameters of local stiffness of arterial wall in correlation with cardiovascular risk factors in hypertensive patients. Material and methods. We carried out cross-sectional population study of workers of an industrial enterprise. The study included 213 individuals, among...

  • New Cardiovascular Risk Factors and Their Use for an Accurate Cardiovascular Risk Assessment in Hypertensive Patients. TAUTU, Oana-Florentina; DARABONT, Roxana; ONCIUL, Sebastian; DEACONU, Alexandru; COMANESCU, Ioana; ANDREI, Radu Dan; DRAGOESCU, Bogdan; CINTEZA, Mircea; DOROBANTU, Maria // Maedica - a Journal of Clinical Medicine;2014, Vol. 9 Issue 2, p127 

    Objectives: To analyze the predictive value of new cardiovascular (CV) risk factors for CV risk assessment in the adult Romanian hypertensive (HT) population. Methods: Hypertensive adults aged between 40-65 years of age, identified in national representative SEPHAR II survey were evaluated by...

  • Effect of whole-body mild-cold exposure on arterial stiffness and central haemodynamics: a randomised, cross-over trial in healthy men and women. King, Sibella; Ahuja, Kiran; Wass, Jezreel; Shing, Cecilia; Adams, Murray; Davies, Justin; Sharman, James; Williams, Andrew // European Journal of Applied Physiology;May2013, Vol. 113 Issue 5, p1257 

    Aortic pulse wave velocity (PWV) and augmentation index (AIx) are independent predictors of cardiovascular risk and mortality, but little is known about the effect of air temperature changes on these variables. Our study investigated the effect of exposure to whole-body mild-cold on measures of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics