TITLE

Characterisation of methicillin resistant S. aureus strains and risk factors for acquisition in a teaching hospital in northeast India

AUTHOR(S)
Sarma, J. B.; Ahmed, G. U.
PUB. DATE
April 2010
SOURCE
Indian Journal of Medical Microbiology;Apr2010, Vol. 28 Issue 2, p127
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: A point prevalence study was carried out in a teaching hospital in Assam to characterise S. aureus strains, establish the rate of colonisation of methicillin resistant S. aureus (MRSA) and associated risk factors for its acquisition. Materials and Methods: Antibiogram-Resistogram profile was done by BSAC standardized disc sensitivity method; Phage and RFLP typing were carried out by the PHLS, London. Results: Single MRSA strain resistant to multiple classes of anti-staphylococcal antibiotics dominated the hospital. The MRSA colonisation rate was found to be 34% (n=29) and 18% (n=80) in orthopaedics and surgery, respectively and only ~1% (n=73) in the medical units. Exposure to ciprofloxacin and surgery were risk factors but duration of hospital stay was not. In contrast, meticillin sensitive S. aureus (MSSA) strains were usually distinct strains and sensitive to most of the anti-staphylococcal antibiotics including 18% to penicillin. Conclusions: The MRSA strain prevalent in the hospital phenotypically resembles the predominant Asian strain viz., Brazilian/Hungarian strains (CC8-MRSA-III). Duration was not a risk factor, which suggests that in absence of exposure to specific antimicrobials, even in a hospital with no or little infection control intervention, a vast majority remain free from MRSA. This underlines the importance of rational prescribing empirical antibiotics.
ACCESSION #
50137881

 

Related Articles

  • Combinations of cefoxitin plus other β-lactams are synergistic in vitro against community associated methicillin-resistant Staphylococcus aureus. Banerjee, R.; Fernandez, M.; Enthaler, N.; Graml, C.; Greenwood-Quaintance, K.; Patel, R. // European Journal of Clinical Microbiology & Infectious Diseases;Jun2013, Vol. 32 Issue 6, p827 

    In vitro studies demonstrate that oxacillin minimal inhibitory concentrations (MICs) of methicillin-resistant S. aureus (MRSA) strains USA300 and 400 decrease in the presence of cefoxitin. The aim of this study was to characterize the activity of cefoxitin plus β-lactams against a collection...

  • Vancomycin Heteroresistance and Methicillin-Resistant Staphylococcus aureus. Deresinski, Stan // Journal of Infectious Diseases;3/1/2009, Vol. 199 Issue 5, p605 

    The article discusses the heteroresistant subpopulations of vancomycin-susceptible Staphylococcus aureus (hVISA). hVISA have minimum inhibitory concentrations (MICs) in the intermediary susceptible range. They have been identified among clinical isolates of methicillin-resistant Staphylococcus...

  • Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2008: general view of the pathogens' antibacterial susceptibility. Niki, Yoshihito; Hanaki, Hideaki; Matsumoto, Tetsuya; Yagisawa, Morimasa; Kohno, Shigeru; Aoki, Nobuki; Watanabe, Akira; Sato, Junko; Hattori, Rikizo; Koashi, Naoto; Terada, Michinori; Kozuki, Tsuneo; Maruo, Akinori; Morita, Kohei; Ogasawara, Kazuhiko; Takahashi, Yoshisaburo; Matsuda, Kenji; Nakanishi, Kunio; Sunakawa, Keisuke; Takeuchi, Kenichi // Journal of Infection & Chemotherapy (Springer Science & Business;Aug2011, Vol. 17 Issue 4, p510 

    For the purpose of nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens collected from patients in Japan, the Japanese Society of Chemotherapy conducted a third year of nationwide surveillance during the period from January to April 2008. A total of...

  • In vitro activity of ceftaroline against Burkholderia pseudomallei. Maloney, Samuel; Engler, Cathy; Norton, Robert // Journal of Antimicrobial Chemotherapy (JAC);Jun2014, Vol. 69 Issue 6, p1716 

    This article reports on a study which investigated the in vitro susceptibility of Burkholderia pseudomallei to ceftaroline. It is noted that ceftaroline is a fourth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). The study concluded that...

  • In vitro antimicrobial activity of ozenoxacin against methicillin-susceptible Staphylococcus aureus, methicillin-resistant S. aureus and Streptococcus pyogenes isolated from clinical cutaneous specimens in Japan. Kanayama, Shoji; Ikeda, Fumiaki; Okamoto, Kazuaki; Nakajima, Akiko; Matsumoto, Tatsumi; Ishii, Ritsuko; Amano, Ayako; Matsuzaki, Kaoru; Matsumoto, Satoru // Journal of Infection & Chemotherapy (Elsevier Inc.);Oct2016, Vol. 22 Issue 10, p720 

    Ozenoxacin, a novel non-fluorinated topical quinolone, was assessed for in vitro antimicrobial activity against each 50 isolates of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes according to the broth microdilution method...

  • Microbial Susceptibility and Plasmid Profiles of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible S. aureus. Shahkarami, Fatemeh; Rashki, Ahmad; Ghalehnoo, Zahra Rashki // Jundishapur Journal of Microbiology;Jul2014, Vol. 7 Issue 7, p1 

    Background: Today, significant increase in the prevalence and emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a serious public health concern and is likely to have a dramatic negative impact on many current medical practices. Therefore, identification of MRSA strains is...

  • MRSA shows alarming increase as pathogen. Guttman, Cheryl // Dermatology Times;Nov2001, Vol. 22 Issue 11, p24 

    Reports the regional spot checking for antibiotic resistance in populations of patients with community acquired impetigo in the United States. Infection of methicillin-resistant Staphylococcus aureus; Cause of the disease; Treatment of appropriate antibiotics.

  • MRSA parotitis. Richards, Will; Steehler, Mark // ENT: Ear, Nose & Throat Journal;Jun2013, Vol. 92 Issue 6, pE66 

    A letter to the editor is presented which discusses methicillin-resistant Staphylococcus aureus (MRSA) parotitis.

  • Comparative Study of Antibacterial Susceptibility Patterns of the Bacteria Isolated from Patients' Blood Samples over Two Periods. Japoni, Aziz; Kalani, Mehdi; Alborzi, Abdolvahab; Japoni, Sara; Rafaatpour, Noradin // American Journal of Infectious Diseases;2011, Vol. 7 Issue 1, p1 

    Problem statement: Due to continuous changes in the frequencies and antibacterial susceptibility patterns of nosocomial pathogens, periodical surveillance of these fluctuations could help the clinicians to treat hospitalized patients more efficiently whenever empirical therapies need to be...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics