TITLE

Immune responses to Epstein-Barr virus in individuals with systemic and organ specific autoimmune disorders

AUTHOR(S)
Kannangai, R.; Sachithanandham, J.; Kandathil, A. J.; Ebenezer, D. L.; Danda, D.; Vasuki, Z.; Thomas, N.; Vasan, S. K.; Sridharan, G.
PUB. DATE
April 2010
SOURCE
Indian Journal of Medical Microbiology;Apr2010, Vol. 28 Issue 2, p120
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Autoimmune diseases usually manifest in genetically predisposed individuals following an environmental trigger. There are several viral infections including Epstein-Barr virus (EBV) implicated in the pathogenesis of autoimmune disorders. The aim of this study was to look at the antibody pattern to EBV proteins in the plasma of both systemic and organ specific autoimmune disorders, estimate pro-inflammatory plasma cytokines (IL-8 and TNF-a) among these autoimmune patients and compare the observations with those in normal healthy controls. Materials and ethods: Samples from 44 rheumatoid arthritis patients, 25 Hashimoto's thyroiditis patients, appropriately age and sex matched healthy controls were tested for EBV IgM antibodies by an immunoblot assay and two cytokines (IL-8 and TNF-a) by commercial assays. Results: Among the rheumatoid arthritis patients, 23 (52%) were positive for EBNA1 antibody, while 13 (52%) of the Hashimoto's thyroiditis patients and 12 (30%) of the healthy controls showed similar bands. The intensity of the bands was high in the autoimmune patients when compared to the bands seen in control samples. The difference in the EBNA1 reactivity between rheumatoid arthritis patients and controls were significant (P = 0.038). There was a significant difference in the IgM reactivity to VCAp19 protein between patients and controls (P = 0.011). Conclusion: Our study showed an increased EBV activation among the autoimmune patient groups compared to the normal healthy controls. Further studies are required to delineate the association between the aetiology of autoimmune disorders and EBV.
ACCESSION #
50137879

 

Related Articles

  • Latent Epstein-Barr virus (EBV) infection and cytomegalovirus (CMV) infection in synovial tissue of autoimmune chronic arthritis determined by RNA- and DNA-in situ hybridization. Mehraein, Yasmin; Lennerz, Carsten; Ehlhardt, Sandra; Remberger, Klaus; Ojak, Andreas; Zang, Klaus D. // Modern Pathology;Jul2004, Vol. 17 Issue 7, p781 

    In rheumatoid arthritis (RA) viral triggers, especially Epstein-Barr virus (EBV) and cytomegalovirus (CMV), have been suggested. By PCR analysis DNA of several viruses among which EBV, CMV, and parvovirus B19 (B19) has been detected in RA synovial fluid and synovial tissue. In 63 synovial...

  • Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis. Komatsuda, Atsushi; Wakui, Hideki; Nimura, Takashi; Sawada, Ken-ichi // Modern Rheumatology (Springer Science & Business Media B.V.);Jun2008, Vol. 18 Issue 3, p315 

    A 63-year-old woman with active rheumatoid arthritis (RA) had been treated with methotrexate and prednisolone. She developed cervical lymph node swelling 30 months after the initiation of infliximab therapy. A computed tomography revealed cervical and mediastinal lymph node swelling and multiple...

  • THE STATE OF ORAL CAVITY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES ACCORDING TO FUNCTIONAL AND LABORATORY SCREENING. Tsimbalistov, A. V.; Robakidze, N. S.; Tyityuk, S. Yu. // Pacific Medical Journal / Tihookeanskij Medicinskij Zurnal;Jan2013, Vol. 51 Issue 1, p51 

    The medical examination of 80 patients with inflammatory bowel diseases allowed to detect the high occurrence of dental pathology like chronic catarrhal and chronic recurrent aphthous stomatitis, inflammatory diseases of paradontium, and find out hemodynamic disorders in paradontium and oral...

  • Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation. Lossius, Andreas; Johansen, Jorunn N.; Torkildsen, Øivind; Vartdal, Frode; Holmøy, Trygve // Viruses (1999-4915);Dec2012, Vol. 4 Issue 12, p3701 

    Epidemiological data suggest that Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by...

  • germ warfare. Dunkin, Mary Anne // Arthritis Today;Sep/Oct2006, Vol. 20 Issue 5, p92 

    The article focuses on the cleanliness theory which proposes that without germs to go after, the immune system may instead attack components of the very body it is supposed to protect and the result can be autoimmune diseases such as rheumatoid arthritis, lupus, multiple sclerosis or type 1...

  • Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report. Michihide Tokuhira; Kyoko Hanzawa; Reiko Watanabe; Yasunobu Sekiguchi; Tomoe Nemoto; Yasuo Toyozumi; Jun-ichi Tamaru; Shinji Itoyama; Katsuya Suzuki; Hideto Kameda; Shigehisa Mori; Masahiro Kizaki // Journal of Hematology & Oncology;2009, Vol. 2, p1 

    Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotraxate usage in RA patients. In...

  • Epstein-Barr virus in peripheral blood is associated with response to rituximab therapy in rheumatoid arthritis patients. Valleala, Heikki; Kauppi, Markku; Kouri, Vesa-Petteri; Korpela, Markku // Clinical Rheumatology;Aug2015, Vol. 34 Issue 8, p1485 

    Autoreactive B cells infected by Epstein-Barr virus (EBV) are suspected to be involved in the etiology of various human chronic autoimmune diseases. This motivated us to study the relationship between peripheral blood EBV load at baseline and treatment response to B cell-depleting therapy in...

  • A case of chronic active Epstein-Barr virus infection mimicking adult-onset Still's disease. Yoshioka, Katsunobu; Fukushima, Hiroko; Ishii, Naomi; Kita, Akiko; Hanioka, Yusuke; Minami, Mieko; Inoue, Takeshi; Yamagami, Keiko // Modern Rheumatology (Springer Science & Business Media B.V.);Jan2013, Vol. 23 Issue 1, p162 

    An 83-year-old man was diagnosed with adult-onset Still's disease (AOSD) based on clinical and laboratory findings. However, glucocorticoid had little effect. Epstein-Barr virus (EBV)-DNA was detected in peripheral blood, and autopsy findings confirmed a diagnosis of chronic active EBV infection...

  • Methotrexate.  // Reactions Weekly;12/9/2006, Issue 1131, p25 

    The article presents a case report of a girl who developed Epstein-Barr virus-associated Hodgkin's disease during treatment with methotrexate for juvenile rheumatoid arthritis, with reference to a study by J. Takeyama, A. Sato et al. in the September 2006 issue of the "Journal of Pediatric...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics