TITLE

Estimation of Thiocolchicoside And Ketoprofen in pharmaceutical dosage form by Spectrophotometric methods

AUTHOR(S)
Wankhede, Sagar B.; Zambare, Somnath S.; Chitlange, Sohan S.
PUB. DATE
April 2010
SOURCE
Journal of Pharmacy Research;Apr2010, Vol. 3 Issue 4, p707
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Two rapid, economical accurate and precise, methods have been developed for estimation of Thiocolchicoside and Ketoprofen in tablet dosage form. First method is first order derivative spectroscopy, wavelengths selected for quantitation were 233.0 nm for Thiocolchicoside (zero cross for Ketoprofen) and 243.0 nm for Ketoprofen (zero cross for Thiocolchicoside). Second method is Absorbance correction method in which absorbance is measured at two wavelengths 372.0 nm at which ketoprofen has no absorbance and 260.0 nm at which both the drugs have considerable absorbance. In first order derivative spectroscopy linearity for detector response was observed in the concentration range of 3-15 μg/ml for Thiocolchicoside and 12-60 μg/ml for Ketoprofen. In Absorbance correction method linearity for detector response was observed in the concentration range of 1-5 μg/ml for Thiocolchicoside and 10-50 μg/ml for Ketoprofen. The proposed methods were successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
ACCESSION #
49802596

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics