TITLE

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

AUTHOR(S)
Tritschler, Felix; Huntzinger, Eric; Izaurralde, Elisa
PUB. DATE
May 2010
SOURCE
Nature Reviews Molecular Cell Biology;May2010, Vol. 11 Issue 5, p379
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
GW182 proteins have emerged as key components of microRNA (miRNA) silencing complexes in animals. Although the precise molecular function of GW182 proteins is not fully understood, new findings indicate that they act as poly(A)-binding protein (PABP)-interacting proteins (PAIPs) that promote gene silencing, at least in part, by interfering with cytoplasmic PABP1 (PABPC1) function during translation and mRNA stabilization. This recent discovery paves the way for future studies of miRNA silencing mechanisms.
ACCESSION #
49486459

 

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