Determination of perfluorinated alkyl acid concentrations in human serum and milk standard reference materials

Keller, Jennifer; Calafat, Antonia; Kato, Kayoko; Ellefson, Mark; Reagen, William; Strynar, Mark; O�Connell, Steven; Butt, Craig; Mabury, Scott; Small, Jeff; Muir, Derek; Leigh, Stefan; Schantz, Michele
May 2010
Analytical & Bioanalytical Chemistry;May2010, Vol. 397 Issue 2, p439
Academic Journal
Standard Reference Materials (SRMs) are certified reference materials produced by the National Institute of Standards and Technology that are homogeneous materials well characterized with values for specified properties, such as environmental contaminant concentrations. They can be used to validate measurement methods and are critical in improving data quality. Disagreements in perfluorinated alkyl acid (PFAA) concentrations measured in environmental matrices during past interlaboratory comparisons emphasized the need for SRMs with values assigned for PFAAs. We performed a new interlaboratory comparison among six laboratories and provided, for the first time, value assignment of PFAAs in SRMs. Concentrations for perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and other PFAAs in two human serum and two human milk SRMs are reported. PFAA concentration measurements agreed for serum SRM 1957 using different analytical methods in six laboratories and for milk SRM 1954 in three laboratories. The interlaboratory relative standard deviation for PFOS in SRM 1957 was 7%, which is an improvement over past interlaboratory studies. Matrix interferences are discussed, as well as temporal trends and the percentage of branched vs. linear isomers. The concentrations in these SRMs are similar to the present-day average concentrations measured in human serum and milk, resulting in representative and useful control materials for PFAA human monitoring studies.


Related Articles

  • Mapping a Course for PFCs. Fields, Scott // Environmental Health Perspectives;Feb2007, Vol. 115 Issue 2, pA97 

    This article discusses the occurrence and levels of perfluorinated chemicals (PFCs) in human milk in relation to maternal serum together with the temporal trend in milk levels in Sweden. Several PFCs were detected in the serum samples, and five of them were also above the detection limits in the...

  • Exposure of Perfluorinated Chemicals through Lactation: Levels of Matched Human Milk and Serum and a Temporal Trend, 1996-2004, in Sweden. Kärrman, Anna; Ericson, Ingrid; Van Bavel, Bert; Darnerud, Per Ola; Aune, Marie; Glynn, Anders; Lignell, Sanna; Lindström, Gunilla // Environmental Health Perspectives;Feb2007, Vol. 115 Issue 2, p226 

    BACKGROUND: Only limited data exist on lactation as an exposure source of persistent perfluorinated chemicals (PFCs) for children. OBJECTIVES: We studied occurrence and levels of PFCs in human milk in relation to maternal serum together with the temporal trend in milk levels between 1996 and...

  • The Extraction of Perfluorinated Alkyl Acids (PFAAs) in Drinking Water Using Automated Cartridge SPE. Wolff, Russ; Caselton, Craig; Cannon, Alicia; Ebitson, Michael // LC-GC North America;Dec2016, Vol. 34 Issue 12, p65 

    The article discusses the extraction of perfluorinated alkyl acids (PFAA) in drinking water using the SmartPrep Cartridge Extraction II System. Topics mentioned include the use of solid phase extraction for the removal and concentration of the PFAA from water samples, determination of Method...

  • Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates. Mogensen, Ulla B.; Grandjean, Philippe; Heilmann, Carsten; Nielsen, Flemming; Weihe, Pál; Budtz-Jørgensen, Esben // Environmental Health: A Global Access Science Source;Jul2015, Vol. 14 Issue 1, p1 

    Background: Exposure to perfluorinated alkylate substances (PFASs) is associated with immune suppression in animal models, and serum concentrations of specific antibodies against certain childhood vaccines tend to decrease at higher exposures. As such, we investigated the immunotoxic impacts of...

  • Determination of perfluorinated compounds in human plasma and serum Standard Reference Materials using independent analytical methods. Reiner, Jessica; Phinney, Karen; Keller, Jennifer // Analytical & Bioanalytical Chemistry;Jan2012, Vol. 401 Issue 9, p2899 

    Perfluorinated compounds (PFCs) were measured in three National Institute of Standards and Technology (NIST) Standard Reference Materials (SRMs) (SRMs 1950 Metabolites in Human Plasma, SRM 1957 Organic Contaminants in Non-fortified Human Serum, and SRM 1958 Organic Contaminants in Fortified...

  • Comparative analysis of ascorbic acid in human milk and infant formula using varied milk delivery systems. Francis, Jimi; Rogers, Kristy; Brewer, Paul; Dickton, Darby; Pardini, Ron // International Breastfeeding Journal;2008, Vol. 3, Special section p1 

    Background: The expression of human milk for later use is on the rise. Bottle systems are used to deliver the expressed milk. Research has shown that storage of both human milk and artificial baby milk, or infant formula, leads to a loss of ascorbic acid (commonly called Vitamin C). As milk is...

  • Perfluorinated Surfactants in Surface and Drinking Waters. Skutlarek, Dirk; Exner, Martin; Fãrber, Harald // Environmental Science & Pollution Research;Mar2007, Vol. 14 Issue 2, p87 

    The article presents environmental sciences and pollution research into perfluorinated surfactants such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in drinking water and surface water samples from the Rhine, Moehne, and Ruhr rivers. Concentrations of perfluorinated...

  • Perfluorinated Alkyl Acid Concentrations in Canadian Rivers and Creeks. Scott, Brian F.; Spencer, Christine; Lopez, Emma; Muir, Derek C. G. // Water Quality Research Journal of Canada (Canadian Association o;2009, Vol. 44 Issue 3, p263 

    Perfluorinated alkyl acids (PFAs) belong to a family of chemicals that are highly persistent and potentially ecotoxic. They are under scrutiny by government agencies who must determine their risk to humans and the environment. Numerous studies have measured perfluorooctanoic acid (PFOA) and...

  • Exploring Indirect Sources of Human Exposure to Perfluoroalkyl Carboxylates (PFCAs): Evaluating Uptake, Elimination, and Biotransformation of Polyfluoroalkyl Phosphate Esters (PAPs) in the Rat. D'eon, Jessica C.; Mabury, Scott A. // Environmental Health Perspectives;Mar2011, Vol. 119 Issue 3, p344 

    BACKGROUND: Perfluorinated carboxylic acids (PFCAs) are ubiquitous in human sera worldwide. Biotransformation of the polyfluoroalkyl phosphate esters (PAPs) is a possible source of PFCA exposure, because PAPs are used in food-contact paper packaging and have been observed in human sera....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics