Paraquat Induced Hepatotoxicity in Albino Mice

Chohan, M. Shahzad; Tahir, Mohammad; Lone, Khalid P.; Sami, Waqas; Munir, Bushra
February 2010
Pakistan Journal of Zoology;2010, Vol. 42 Issue 1, p69
Academic Journal
The article presents a study which evaluates the chronic effects of hepatotoxicity of herbicide paraquat on the liver of the albino mice after sublethal exposure to drug. It states that forty adult male mice were collected from Islamabad, and were divided into two groups, Group A as control group with 15 mice and Group B as experimental with 25 mice. The experimental group was given a single dose of paraquat dissolved in 0.2 ml of saline through injection, while the control group was given an equal amount of saline by the sale route. On the tenth day of the experiment, all animals were sacrificed, whose livers were removed and processed for routine histology. Results show that control group have infiltration of lymphocytes and macrophages.


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