TITLE

The 'silver' Japanese quail and the MITF gene: causal mutation, associated traits and homology with the 'blue' chicken plumage

AUTHOR(S)
Minvielle, Francis; Bed'hom, Bertrand; Coville, Jean-Luc; Ito, Shińichi; Inoue-Murayama, Miho; Gourichon, David
PUB. DATE
January 2010
SOURCE
BMC Genetics;2010, Vol. 11, p15
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The MITF (microphthalmia-associated transcription factor) gene has been investigated in mice and various vertebrates but its variations and associated effects have not yet been explored much in birds. The present study describes the causal mutation B at the MITF gene responsible for the "silver" plumage colour in the Japanese quail (Coturnix japonica), and its associated effects on growth and body composition, and tests its allelism with the "blue" plumage colour mutation Bl in Gallus gallus. Results: The semi dominant B mutation results from a premature stop codon caused by a 2 bp deletion in exon 11 of MITF. Homozygous "white" (B/B) quail which have a white plumage also show a slightly lower growth, lower body temperature, smaller heart, and lighter pectoralis muscles but more abdominal adipose tissue than the recessive homozygous "wild-type" (+/+) and heterozygous "silver" (B/+) quail. Similar observations on cardiac and body growth were made on mice (Mus musculus) homozygous for mutations at MITF. The production of chickenquail hybrids with a white plumage obtained by crossing Bl/+ chicken heterozygous for the blue mutation with B/B white quail indicated that the mutations were allelic. Conclusion: The "silver" Japanese quail is an interesting model for the comparative study of the effects of MITF in birds and mammals. Further investigation using a chicken family segregating for the "blue" plumage and molecular data will be needed to confirm if the "blue" plumage in chicken results from a mutation in MITF.
ACCESSION #
49212366

 

Related Articles

  • New findings in the stumpy-limb mutation of Japanese quail. Tsudzuki, M. // Journal of Heredity;Jan/Feb95, Vol. 86 Issue 1, p66 

    Describes reproductive characteristics of viable stumpy-limb (SL) mutants of Japanese quail (Coturnic japonica) and the results of breeding experiments. Weight and sex differences; Progeny acquired; Survival rate; Mobility of progeny; Physical attributes of mutant offspring.

  • Identifying the Deleterious Effect of Rare LHX4 Allelic Variants, a Challenging Issue. Rochette, Claire; Jullien, Nicolas; Saveanu, Alexandru; Caldagues, Emmanuelle; Bergada, Ignacio; Braslavsky, Debora; Pfeifer, Marija; Reynaud, Rachel; Herman, Jean-Paul; Barlier, Anne; Brue, Thierry; Enjalbert, Alain; Castinetti, Frederic // PLoS ONE;May2015, Vol. 10 Issue 5, p1 

    LHX4 is a LIM homeodomain transcription factor involved in the early steps of pituitary ontogenesis. To date, 8 heterozygous LHX4 mutations have been reported as responsible of combined pituitary hormone deficiency (CPHD) in Humans. We identified 4 new LHX4 heterozygous allelic variants in...

  • Allele Compensation in Tip60+/− Mice Rescues White Adipose Tissue Function In Vivo. Gao, Yuan; Hamers, Nicole; Rakhshandehroo, Maryam; Berger, Ruud; Lough, John; Kalkhoven, Eric // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Adipose tissue is a key regulator of energy homestasis. The amount of adipose tissue is largely determined by adipocyte differentiation (adipogenesis), a process that is regulated by the concerted actions of multiple transcription factors and cofactors. Based on in vitro studies in murine 3T3-L1...

  • The murine misty mutation: Phenotypic effects of melanocytes, platelets and brown fat. Sviderskaya, Elena V.; Novak, Edward K.; Swank, Richard T.; Bennett, Dorothy C. // Genetics;Jan98, Vol. 148 Issue 1, p381 

    Provides information on a study reporting the effects of the homozygous misty mutation on an unusual combination of three cell types, melanocytes, platelets, and brown fat. Methodology used to conduct the study; Results of the study; Discussion on the results.

  • The Statistical Analysis of Some Volumetric Measurements in the Japanese Quails' Head with Different Feather Color: A Computed Tomography Study. DUYMUŞ, Mahmut; DEMIRASLAN, Yasin; AKBULUT, Yalçın; ORMAN, Güneş; ASLAN, Kadir; OZCAN, Sami // Kafkas Universitesi Veteriner Fakultesi Dergisi;Jul/Aug2013, Vol. 19 Issue 4, p681 

    The aim of this study was to contribute to quail head morphology and the formation of basic data sources for comparative measurement in the quail head. In this study, 60 Japanese quail (Coturnix japonica) heads, which were white, brown and wild type were used. Four different anatomical...

  • Living with bad architecture. Lovell-Badge, Robin // Nature;8/31/1995, Vol. 376 Issue 6543, p725 

    Discusses the common link between two different forms of aberrant growth which are the benign tumors in humans and the pygmy phenotype in mice published in the August 31, 1995 issue of Nature. Mutations in gene encoding known as architectural transcription factor known as HMGI-C; Attention...

  • New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nehls, Michael; Pfeifer, Dietmar // Nature;11/3/1994, Vol. 372 Issue 6501, p103 

    Shows the encoding of a new member of the winged-helix domain family of transcription factors by one of the genes from the nude locus of mice and rats in chromosome 11. Mutations at nude locus causing disruption of hair growth and thymus development; Consequences of mutations in winged-helix...

  • Genetic Variation in Saccharomyces cerevisiae: Circuit Diversification in a Signal Transduction Network. Chin, Brian L.; Ryan, Owen; Lewitter, Fran; Boone, Charles; Fink, Gerald R. // Genetics;Dec2012, Vol. 192 Issue 4, p1523 

    The connection between genotype and phenotype was assessed by determining the adhesion phenotype for the same mutation in two closely related yeast strains, S288c and Sigma, using two identical deletion libraries. Previous studies, all in Sigma, had shown that the adhesion phenotype was...

  • Development and Performances of a Japanese Quail Line Homozygous for the Diabetes Insipidus (di) Mutation. Minvielle, F.; Grossmann, R.; Gourichon, D. // Poultry Science;Feb2007, Vol. 86 Issue 2, p249 

    A strain of Japanese quail with the polyuria disorder (excessive urination) was developed from founders that regurgitated water spontaneously. A backcross with a nonpolyuric quail line showed that the polyuric strain was fixed for an autosomal recessive mutation that also induced polydipsia...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics