TITLE

Development and validation of a population-based prediction scale for osteoporotic fracture in the region of Valencia, Spain: the ESOSVAL-R study

AUTHOR(S)
Sanfélix-Genovés, José; Peiró, Salvador; Sanfélix-Gimeno, Gabriel; Giner, Vicente; Gil, Vicente; Pascual, Manuel; Fluixá, Carlos; Fuertes, Antonio; Hurtado, Isabel; Ferreros, Inmaculada
PUB. DATE
January 2010
SOURCE
BMC Public Health;2010, Vol. 10 Issue 1, p153
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Today, while there are effective drugs that reduce the risk of osteoporotic fracture, yet there are no broadly accepted criteria that can be used to estimate risks and decide who should receive treatment. One of the actual priorities of clinical research is to develop a set of simple and readily-available clinical data that can be used in routine clinical practice to identify patients at high risk of bone fracture, and to establish thresholds for therapeutic interventions. Such a tool would have high impact on healthcare policies. The main objective of the ESOSVAL-R is to develop a risk prediction scale of osteoporotic fracture in adult population using data from the Region of Valencia, Spain. Methods/Design: Study design: An observational, longitudinal, prospective cohort study, undertaken in the Region of Valencia, with an initial follow-up period of five years; Subjects: 14,500 men and women over the age of 50, residing in the Region and receiving healthcare from centers where the ABUCASIS electronic clinical records system is implanted; Sources of data: The ABUCASIS electronic clinical record system, complemented with hospital morbidity registers, hospital Accidents & Emergency records and the Regional Ministry of Health's mortality register; Measurement of results: Incident osteoporotic fracture (in the hip and/or major osteoporotic fracture) during the study's follow-up period. Independent variables include clinical data and complementary examinations; Analysis: 1) Descriptive analysis of the cohorts' baseline data; 2) Upon completion of the follow-up period, analysis of the strength of association between the risk factors and the incidence of osteoporotic fracture using Cox's proportional hazards model; 3) Development and validation of a model to predict risk of osteoporotic fracture; the validated model will serve to develop a simplified scale that can be used during routine clinical visits. Discussion: The ESOSVAL-R study will establish a prediction scale for osteoporotic fracture in Spanish adult population. This scale not only will constitute a useful prognostic tool, but also it will allow identifying intervention thresholds to support treatment decision-making in the Valencia setting, based mainly on the information registered in the electronic clinical records.
ACCESSION #
49164341

 

Related Articles

  • A Review of Osteoporosis: Part I. Impact, Pathophysiology, Diagnosis and Unique Role of the Physiatrist Kasturi, Gopi C.; Cifu, David X.; Adler, Robert A. // PM & R: Journal of Injury, Function & Rehabilitation;Mar2009, Vol. 1 Issue 3, p254 

    Osteoporosis is characterized by decreased bone quantity and quality, leading to increased fracture risk. Despite important strides in understanding and treating this disorder, there is a large gap between knowledge and practice. In this first section of a 3-part review, the impact,...

  • Incidence of osteoporosis in men.  // American Family Physician;6/1/1997, Vol. 55 Issue 8, p2852 

    Discusses the occurrence of osteoporosis and hip fracture among men published in the `Australian Family Physician,' dated February, 1997. Preventive measures of fractures; Related diseases; Treatment of diseases.

  • Identifying Individuals at Risk for Fracture in Guatemala. Nasser, Keaton M.; Obiols, Alejandro Quiñónez; Silverman, Stuart L. // PLoS ONE;2011, Vol. 6 Issue 11, p1 

    Introduction: The FRAX calculator combines a set of clinical risk factors with country-specific incidence rates to determine the ten-year absolute risk of major osteoporotic fracture. However, regional or country-specific databases from Central American countries are not available. We compared...

  • Atypical Femoral Fractures, Bisphosphonates, and Adult Hypophosphatasia. Whyte, Michael P. // Journal of Bone & Mineral Research;Jun2009, Vol. 24 Issue 6, p1132 

    The article presents an overview of research which examined the association between femoral fractures and hypophosphatasia and femoral fractures and the use of the bisphosphonate alendronate which is used to treat osteoporosis in older people. A discussion of the causes of hypophosphatasia is...

  • The Roles of Bone Mineral Density, Bone Turnover, and Other Properties in Reducing Fracture Risk During Antiresorptive Therapy. Epstein, Solomon // Mayo Clinic Proceedings;Mar2005, Vol. 80 Issue 3, p379 

    Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Properties related to bone strength include rate of bone turnover, bone mineral density, geometry, microarchitecture, and mean degree of mineralization. These properties (with or...

  • Bone regeneration: current concepts and future directions. Dimitriou, Rozalia; Jones, Elena; McGonagle, Dennis; Giannoudis, Peter V. // BMC Medicine;2011, Vol. 9 Issue 1, p66 

    Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in...

  • Chaos as NICE does U-turn on osteoporosis guidance. Finch, Rob // Pulse;5/17/2004, Vol. 64 Issue 20, p17 

    Reports on criticisms against the National Institute for Clinical Excellence for releasing confusing guidelines on the secondary prevention of bone fractures in postmenopausal women. Initial recommendations on osteoporosis.

  • Funding threat to prescribing plan.  // Pulse;5/17/2004, Vol. 64 Issue 20, p17 

    Reports on criticisms against the National Institute for Clinical Excellence for releasing confusing guidelines on the secondary prevention of bone fractures in postmenopausal women. Initial recommendations on osteoporosis.

  • Osteoporosis. Sahley, Billie J. // MMRC Health Educator Reports;2010, p1 

    The article offers information about osteoporosis and the means to prevent bone loss and fractures associated with the disease. Osteoporosis entails having low bone density which is usually asymptomatic. Symptoms associated with osteoporosis are chronic backache and an accompanying stooped...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics