Presumed nephrogenic diabetes insipidus secondary to chronic copper hepatotoxicity in sheep

Giadinis, N. D.; Polizopoulou, Z.; Roubies, N.; Karatzias, H.
April 2010
Veterinary Record: Journal of the British Veterinary Association;4/3/2010, Vol. 166 Issue 14, p433
Academic Journal
The article focuses on the description of a syndrome suffered by two sheep specifically from toxic hepatopathy associated with chronic copper poisoning in Europe. The syndrome has been characterized by polyuria-polydipsia (PUPD) and very low urine specific gravity (USG). The sheeps have been reported to have ovine central diabetes insipidus secondary to structural brain disease wherein daily injections of clanobutin and chelating therapy were administered.


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