TITLE

Correlation between Hyperghrelinemia and Carotid Artery Intima-Media Thickness in Children with Prader-Willi Syndrome

AUTHOR(S)
Su Jin Kim; Kyung Hoon Paik; Dong-Ik Kim; Yon Ho Choe; Seon Woo Kim; Dong-Kyu Jin
PUB. DATE
May 2010
SOURCE
Yonsei Medical Journal;5/1/2010, Vol. 51 Issue 3, p339
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability. The objective of the study is to assess the relationship between carotid intima-media thickness (IMT) and atherosclerotic risk factors. Materials and Methods: Twenty-seven PWS children and 24 normal controls were enrolled. Correlations of IMT with atherosclerotic risk factors were assessed. Results: IMTs in the PWS group did not differ from those in the controls (p = 0.172), although total ghrelin levels were higher in the PWS children (p = 0.003). The multivariate analysis revealed positive correlations between total ghrelin levels ( = 0.489, p = 0.046) and IMT in the PWS group and between body mass index-standard deviation score (BMI-SDS) ( = 0.697, p = 0.005) and IMT in the controls. Conclusion: Considering the positive correlation of IMT with total ghrelin levels and the high level of ghrelin in PWS children, a further study is warranted to evaluate the role of elevated ghrelin on atherosclerosis for PWS.
ACCESSION #
49115180

 

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