Correlation between Hyperghrelinemia and Carotid Artery Intima-Media Thickness in Children with Prader-Willi Syndrome

Su Jin Kim; Kyung Hoon Paik; Dong-Ik Kim; Yon Ho Choe; Seon Woo Kim; Dong-Kyu Jin
May 2010
Yonsei Medical Journal;5/1/2010, Vol. 51 Issue 3, p339
Academic Journal
Purpose: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability. The objective of the study is to assess the relationship between carotid intima-media thickness (IMT) and atherosclerotic risk factors. Materials and Methods: Twenty-seven PWS children and 24 normal controls were enrolled. Correlations of IMT with atherosclerotic risk factors were assessed. Results: IMTs in the PWS group did not differ from those in the controls (p = 0.172), although total ghrelin levels were higher in the PWS children (p = 0.003). The multivariate analysis revealed positive correlations between total ghrelin levels ( = 0.489, p = 0.046) and IMT in the PWS group and between body mass index-standard deviation score (BMI-SDS) ( = 0.697, p = 0.005) and IMT in the controls. Conclusion: Considering the positive correlation of IMT with total ghrelin levels and the high level of ghrelin in PWS children, a further study is warranted to evaluate the role of elevated ghrelin on atherosclerosis for PWS.


Related Articles

  • From the Editor. Albertini, David F. // Journal of Assisted Reproduction & Genetics;Aug2009, Vol. 26 Issue 8, p425 

    The author reflects on the importance of recent advances in genetic diagnoses for a better characterization of debilitating skeletal disorders and imprinting disorders. He informs that adverse gestational conditions is brought by children with Prader-Willi Syndrome. The author shares that...

  • Hyperghrelinemia in the patients presenting with Prader-Willi syndrome. BOGOVA, E. A.; VOLEVODZ, N. N.; ILYIN, A. V.; PETERKOVA, V. A. // Problemy Endokrinologii;2014, Vol. 60 Issue 3, p30 

    The present study was designed to measure pre- and postprandial ghrelin secretion in the children presenting with Prader-Willi syndrome (PWS). The clinical, hormonal, and metabolic characteristics of 17 prepubertal children with the genetically verified diagnosis of PWS, 15 patients with...

  • Birth prevalence of Prader-Willi syndrome in Australia. Smith, A.; Egan, J.; Ridley, G.; Haan, E.; Montgomery, P.; Williams, K.; Elliott, E. // Archives of Disease in Childhood;Mar2003, Vol. 88 Issue 3, p263 

    Background: Until recently, midazolam sedation was routinely used in our institution for bone marrow aspirates and lumbar punctures in children with cancer. It has been perceived by many doctors and nurses as being well tolerated by children and their families. Aim: To compare the efficacy of...

  • Prader-Willi syndrome.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1866 

    An encyclopedia entry for "Prader-Willi syndrome," which refers to a rare genetic disorder marked by genetic obesity, hyperphagia, mental retardation and other clinical signs and features, is presented.

  • Lucina.  // Archives of Disease in Childhood;Jul2002, Vol. 87 Issue 1, p86 

    Presents news updates on childhood diseases, compiled as of July 2002. Prevalence of phobias in children; Risk factors for the onset of wheezing; Incidence of severe psychiatric treatment in adults with Prader Willi syndrome.

  • Atoms. Bauchner, Howard // Archives of Disease in Childhood;Dec2008, Vol. 93 Issue 12, pi 

    The article offers news briefs related to childhood diseases. Growth hormone for children with Prader-Wili syndrome might have long-term adverse effects, including the worsening of obstructive sleep apnoea. There is a declined number of incidence of infantile hyperthropic pyloric stenosis...

  • French database of children and adolescents with Prader-Willi syndrome. Molinas, Catherine; Cazals, Laurent; Diene, Gwenaelle; Glattard, Melanie; Arnaud, Catherine; Tauber, Maithe // BMC Medical Genetics;2008, Vol. 9, Special section p1 

    Background: Prader-Willi syndrome (PWS) is a rare multisystem genetic disease leading to severe complications mainly related to obesity. We strongly lack information on the natural history of this complex disease and on what factors are involved in its evolution and its outcome. One of the...

  • Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients. Tauber, Maïthe; Mantoulan, Carine; Copet, Pierre; Jauregui, Joseba; Demeer, Genevieve; Diene, Gwenaëlle; Rogé, Bernadette; Laurier, Virginie; Ehlinger, Virginie; Arnaud, Catherine; Molinas, Catherine; Thuilleaux, Denise // Orphanet Journal of Rare Diseases;2011, Vol. 6 Issue 1, p47 

    Background: Prader-Willi syndrome (PWS) is a complex neurodevelopmental genetic disorder with hypothalamic dysfunction, early morbid obesity with hyperphagia, and specific psychiatric phenotypes including cognitive and behavioural problems, particularly disruptive behaviours and...

  • The Effect of the Presence of Others on Caloric Intake in Homebound Older Adults. Locher, Julie L.; Robinson, Caroline O.; Roth, David L.; Ritchie, Christine S.; Burgio, Kathryn L. // Journals of Gerontology Series A: Biological Sciences & Medical ;Nov2005, Vol. 60 Issue 11, p1475 

    Background. Undernutrition in homebound older adults is a significant problem. The purpose of this study was to investigate the effect of the presence of others, both within the household and during meals, on caloric intake in homebound older adults. Methods. In-depth interviews and three...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics