TITLE

Method Development for Drug Impurity Profiling: Part 1

AUTHOR(S)
Dejaegher, Bieke; Dumarey, Melanie; Heyden, Yvan Vander
PUB. DATE
April 2010
SOURCE
LC-GC Europe;Apr2010, Vol. 23 Issue 4, p218
SOURCE TYPE
Trade Publication
DOC. TYPE
Article
ABSTRACT
In this Practical Data Handling column, method development for drug impurity profiling is discussed. This first part consists of the first two steps when developing a drug impurity profile: the selection of a suitable chromatographic column and the optimization of the mobile phase pH. Prior to the impurity profiling, the selection of a set of dissimilar chromatographic columns is made (i.e., columns with different selectivities) to be screened with the impurity mixture for selectivity differences.
ACCESSION #
49091199

 

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