TITLE

DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis

AUTHOR(S)
Mössner, Rainald; Schuhmacher, Anna; Wagner, Michael; Quednow, Boris B.; Frommann, Ingo; Kühn, Kai-Uwe; Schwab, Sibylle G.; Rietschel, Marcella; Falkai, Peter; Wölwer, Wolfgang; Ruhrmann, Stephan; Bechdolf, Andreas; Gaebel, Wolfgang; Klosterkötter, Joachim; Maier, Wolfgang
PUB. DATE
April 2010
SOURCE
European Archives of Psychiatry & Clinical Neuroscience;Apr2010, Vol. 260 Issue 3, p209
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The genetic factors determining the progression of prodromal syndromes to first episode schizophrenia have remained enigmatic to date. In a unique prospective multicentre trial, we assessed whether variants at the d-amino acid oxidase activator (DAOA)/G72 locus influence progression to psychosis. Young subjects with a prodromal syndrome were observed prospectively for up to 2 years to assess the incidence of progression to schizophrenia or first episode psychosis. Of the 82 probands with a prodromal syndrome, 21 probands experienced progression to psychosis within the observation period. Assessment of nine common variants in the DAOA/G72 locus yielded two variants with the predictive value for symptom progression: all four probands with the rs1341402 CC genotype developed psychosis compared with 17 out of 78 probands with the TT or CT genotypes (χ2 = 12.348; df = 2; p = 0.002). The relative risk for progression to psychosis was significantly increased in the CC genotype: RR = 4.588 (95% CI = 2.175–4.588). Similarly, for rs778294, 50% of probands with the AA genotype, but only 22% of probands with a GG or GA genotype progressed to psychosis (χ2 = 7.027; df = 2; p = 0.030). Moreover, haplotype analysis revealed a susceptibility haplotype for progression to psychosis. This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia.
ACCESSION #
49086828

 

Related Articles

  • The neurobiology of D-amino acid oxidase and its involvement in schizophrenia. Verrall, L.; Burnet, P. W. J.; Betts, J. F.; Harrison, P. J. // Molecular Psychiatry;Feb2010, Vol. 15 Issue 2, p122 

    D-amino acid oxidase (DAO) is a flavoenzyme that metabolizes certain D-amino acids, notably the endogenous N-methyl D-aspartate receptor (NMDAR) co-agonist, D-serine. As such, it has the potential to modulate the function of NMDAR and to contribute to the widely hypothesized involvement of NMDAR...

  • PRODROMAL PHASE IN THE DEVELOPMENT OF EARLY ONSET SCHIZOPHRENIC PSYCHOSIS - CASE REPORT. Kostić, Jelena; Stanković, Miodrag; Nešić, Milkica; Krasić, Dragana // Acta Medica Medianae;Jun2012, Vol. 51 Issue 2, p19 

    Schizophrenia and other mental disorders are often preceded by prodromal changes in behavior that can last from several days to several years, indicating the beginning of psychosis. If the disease starts at an earlier age, especially in adolescence, the prodromal phase is more non-specific and...

  • Preliminary evidence for an association between aggressive and hostile behaviour and 3α,5α-tetrahydroprogesterone plasma levels in schizophrenia. Spalletta, Gianfranco; Romeo, Elena; Bonaviri, Giuseppina; Bernardi, Giorgio; Caltagirone, Carlo; di Michele, Flavia // Journal of Psychiatry & Neuroscience;Jan2005, Vol. 30 Issue 1, p49 

    Because it has been suggested that agents acting on the γ-aminobutyric acid-A (GABAA) receptor complex, such as the neuroactive steroid 3α,5α-tetrahydroprogesterone (3α,5α-THP), may be biologic modulators of aggression, we aimed to measure 3α,5α- THP plasma concentrations in...

  • An association of the polymorphic repeat of tetranucleotide (TCAT) in the first intron of the human tyrosine hydroxylase gene with schizophrenia in a Japanese sample. Kurumaji, A.; Kuroda, T.; Yamada, K.; Yoshikawa, T.; Toru, M. // Journal of Neural Transmission;Apr2001, Vol. 108 Issue 4, p489 

    Summary. Tyrosine hydroxylase (TH) is the rate limiting enzyme in the synthesis of dopamine and norepinephrine. A polymorphic repeat of the tetranucleotide (TCAT) in the first intron of the TH gene may behave as a regulatory element for the gene expression. Allelic fragments of the tandem repeat...

  • Molecular genetic studies of cognitive deficit in schizophrenia. Golimbet, V. E. // Molecular Biology;Sep2008, Vol. 42 Issue 5, p738 

    Cognitive deficit is a key feature of schizophrenia. Genetic factors are thought to contribute to cognitive disturbances in schizophrenic patients. However, the role of specific genes in the development of cognitive deficit remains elusive. The review considers the current studies on the...

  • Addressing the unmet needs of patients with persistent negative symptoms of schizophrenia: emerging pharmacological treatment options. Chue, Pierre; Lalonde, Justine K. // Neuropsychiatric Disease & Treatment;2014, Vol. 10, p777 

    The negative symptoms of schizophrenia represent an impairment of normal emotional responses, thought processes and behaviors, and include blunting or flattening of affect, alogia/aprosody, avolition/apathy, anhedonia, and asociality. Negative symptoms contribute to a reduced quality of life,...

  • Editorial. Buckley, Peter F. // Clinical Schizophrenia & Related Psychoses;Fall2015, Vol. 9 Issue 3, p112 

    An introduction is presented in which the editor discusses various reports within the issue on topics including recovery process in schizophrenia, psychosis, and metabolic syndrome.

  • Association of grey matter volume deviation with insight impairment in first-episode affective and non-affective psychosis. McFarland, John; Cannon, Dara; Schmidt, Heike; Ahmed, Mohamed; Hehir, Sarah; Emsell, Louise; Barker, Gareth; McCarthy, Peter; Elliott, Mark; McDonald, Colm // European Archives of Psychiatry & Clinical Neuroscience;Mar2013, Vol. 263 Issue 2, p133 

    The neurobiological correlates of impaired insight in psychotic illness remain uncertain and may be confounded by factors such as illness progression and medication use. Our study consisted of two separate experiments. In the first experiment, we examined the association between measures of...

  • Abnormal Stress Responsivity in a Rodent Developmental Disruption Model of Schizophrenia. Zimmerman, Eric C; Bellaire, Mark; Ewing, Samuel G; Grace, Anthony A // Neuropsychopharmacology;Oct2013, Vol. 38 Issue 11, p2131 

    Although numerous studies have implicated stress in the pathophysiology of schizophrenia, less is known about how the effects of stress interact with genetic, developmental, and/or environmental determinants to promote disease progression. In particular, it has been proposed that in humans,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics