TITLE

Serum Paraoxonase 1 Activity Status in Patients with Liver Disorders

AUTHOR(S)
Kedage, Vivekananda; Muttigi, Manjunatha S.; Shetty, Mahesh S.; Suvarna, Renuka; Rao, Soumya S.; Joshi, Chitralekha; Prakash, Mungli
PUB. DATE
April 2010
SOURCE
Saudi Journal of Gastroenterology;Apr2010, Vol. 16 Issue 2, p79
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background/Aim: Paraoxonase 1 (PON1) is an esterase, exclusively synthesized by liver. The present study has two objectives: to determine the PON1 activity status in various disorders associated with hepatocellular damage and to correlate the changes of PON1 activity with the standard liver function and fasting lipid profi le tests in these disorders. Patients and Methods: The study groups consisted of 95 patients with liver diseases including acute viral hepatitis (14), cirrhosis with portal hypertension (33), leptospirosis (14), sepsis and multi organ failure (15), left ventricular failure (9), and falciparum malaria (10); and 53 healthy controls. Serum PON1 activity was measured manually using spectrophotometer. Liver function test parameters and fasting lipid profile were performed in clinical chemistry auto analyzer (Hitachi 912). Results: The serum PON1 activity in patients with acute viral hepatitis and sepsis decreased signifi cantly (P<0.001) and moderately in falciparum malaria (P<0.05). However, in patients with cirrhosis, leptospirosis and left ventricular patients, its activity did not change signifi cantly. On applying Pearson correlation, serum PON1 activity correlated positively with high-density lipoprotein-cholesterol (HDL-C) in patients with sepsis (r=0.633, P<0.05), left ventricular failure patients (r=0.814, P<0.05) and negatively with acute viral hepatitis patients (r=-0.528, P<0.05). Conclusion: PON1 activity has decreased significantly in acute viral hepatitis, sepsis with multi organ failure and falciparum malaria patients. Determination of PON1 activity may serve as a useful additional test in assessing these conditions.
ACCESSION #
48988950

 

Related Articles

  • KaraciÄŸer sirozlu hastalarda laparoskopik kolesistektomi. Teke, Zafer; Ercan, Metin; Ulaş, Murat; Dalgıç, Tahsin; Bostancı, Erdal Birol; Akoğlu, Musa // Turkish Journal of Surgery / Ulusal Cerrahi Dergisi;2010, Vol. 26 Issue 3, p146 

    Purpose: In this study, we aimed to evaluate surgical outcomes of cirrhotic patients who underwent laparoscopic cholecystectomy for gallstones in our clinic. Patients and Methods: From 2003-2009, 18 cirrhotic patients underwent laparoscopic cholecystectomy for gallstones in our clinic....

  • Ultrasonography in differentiation between chronic viral hepatitis and compensated early stage cirrhosis. Iliopoulos, Panagiotis; Vlychou, Marianna; Karatza, Chrisoula; Yarmenitis, Spyros D.; Repanti, Maria; Tsamis, Ioannis; Tepetes, Kostantinos; Misra, Sri Prakash // World Journal of Gastroenterology;4/7/2008, Vol. 14 Issue 13, p2072 

    AIM: To assess the value of gray scale (GS) and colour Doppler ultrasonography (CDU) in differentiating the progression of chronic viral hepatitis (CVH) and compensated liver cirrhosis (CIR). METHODS: Seventy-two patients and 32 normal individuals who were used as controls were studied....

  • Hepatopulmonary syndrome in patients with chronic liver disease: role of pulse oximetry. Deibert, Peter; Allgaier, Hans-Peter; Loesch, Stefanie; Müller, Claudia; Olschewski, Manfred; Hamm, Hinrich; Maier, Klaus-Peter; Erich Blum, Hubert // BMC Gastroenterology;2006, Vol. 6, p15 

    Background: Hepatopulmonary syndrome (HPS) is a rare complication of liver diseases of different etiologies and may indicate a poor prognosis. Therefore, a simple non-invasive screening method to detect HPS would be highly desirable. In this study pulse oximetry was evaluated to identify...

  • Myocardial late gadolinium enhancement cardiovascular magnetic resonance in patients with cirrhosis. Lossnitzer, Dirk; Steen, Henning; Zahn, Alexandra; Lehrke, Stephanie; Weiss, Celine; Weiss, Karl Heinz; Giannitsis, Evangelos; Stremmel, Wolfgang; Sauer, Peter; Katus, Hugo A.; Gotthardt, Daniel N. // Journal of Cardiovascular Magnetic Resonance (BioMed Central);2010, Vol. 12, p47 

    Background: Portal hypertension and cardiac alterations previously described as "cirrhotic cardiomyopathy" are known complications of end stage liver disease (ELD). Cardiac failure contributes to morbidity and mortality, particularly after liver transplantation and transjugular intrahepatic...

  • NadciÅ›nienie wrotne pochodzenia pozawÄ…trobowego. Sudnik, Magdalena; Semianów-Wejchert, Jarosława; Paradowski, Leszek // Gastroenterologia Polska / Gastroenterology;2011, Vol. 18 Issue 4, p163 

    The most common cause of portal hypertension is hepatic cirrhosis. It mainly concerns both European and North American patients. For every tenth patient the portal hypertension is caused by prehepatic or posthepatic block. In the following paper we present the most important causes of...

  • Effect of Transjugular Intrahepatic Portosystemic Shunt Formation on Portal Hypertensive Gastropathy and Gastric Circulation. Mezawa, Shinichi; Homma, Hisato; Ohta, Hidetoshi; Masuko, Eiichi; Doi, Tadashi; Miyanishi, Koji; Takada, Koichi; Kukitsu, Takehiro; Sato, Tsutomu; Niitsu, Yoshiro // American Journal of Gastroenterology;Apr2001, Vol. 96 Issue 4, p1155 

    OBJECTIVES: The aim of this study was to investigate the effect of a transjugular intrahepatic portosystemic shunt (TIPS) on portal hypertensive gastropathy (PHG) and gastric hemodynamics. METHODS: A total of 16 patients with cirrhosis and portal hypertensive gastropathy were prospectively...

  • Portal Hypertension Due to Hepatic Sarcoidosis. Berger, Ira; Katz, Monique // American Journal of Gastroenterology;Feb1973, Vol. 59 Issue 2, p147 

    Presents a case study of portal hypertension due to hepatic sarcoidosis. Case report; Results of a liver and spleen scan conducted on the patient; Frequency of the occurrence of secondary portal hypertension.

  • Activity of Gastric Mucosal Nitric Oxide Synthase in Portal Hypertensive Gastropathy. El-Newihi, Hussein M.; Kanji, Vijaya K.; Mihas, Anastasios A. // American Journal of Gastroenterology;Mar1996, Vol. 91 Issue 3, p535 

    Objective: The importance of portal hypertensive gastropathy, as a potentially bleeding lesion in cirrhotics with portal hypertension, has recently been appreciated. Histologically, dilation of the mucosal and submucosal vessels of the stomach is noted in this entity. The possibility of nitric...

  • THE ROLE OF SURGERY IN THE TREATMENT OF PORTAL HYPERTENSIONS. Mulder, Donald G. // American Journal of Gastroenterology;Mar1960, Vol. 33 Issue 3, p305 

    Presents study which discussed the role of surgery in the treatment of portal hypertension. Impact of portal venous thrombosis on portal hypertension and bleeding esophageal varices; Contribution of peptic esophagitis to the development of the disease; importance of side-to-side portacaval...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics