Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: a meta-analysis of longitudinal studies

Li-ping He; Xin-yi Tang; Wen-hua Ling; Wei-qing Chen; Yu-ming Chen
March 2010
Heart;Mar2010, Vol. 96 Issue 5, p339
Academic Journal
Objective To assess the overall effects by a meta-analysis. Data sources Electronic searches on PubMed and Ovid Medline from their start to October 2009 were carried out. Objective Cohort studies and secondary analysis of randomised controlled trials reporting the relative risk (RR) of recurrent cardiovascular events or death associated with C-reactive protein (CRP) obtained within 72 h from acute coronary syndromes (ACS) onset. Data extraction Two epidemiologists independently abstracted information on study design, study and participant characteristics, level of CRP, outcomes, control for potential confounding factors and risk estimates using a standardised form. Results A general variance-based method was used to pool the estimates of risk. Thirteen studies containing 1364 new cases identified from 9787 patients during the follow-up periods reported the risk estimates by CRP categories. Compared with the bottom CRP category (≤3 mg/l), the pooled RRs and their 95% CIs were 1.40 (1.18 to 1.67) for the middle (3.1∼10 mg/l) category and 2.18 (1.77 to 2.68) for the top (>10 mg/l) category of CRP values with a random-effects model, respectively. Another four and three studies reported the risk by unit of CRP or logarithmically transformed CRP. The pooled RRs (95% CI) were 1.49 (1.06 to 2.08) per 5 mg/l and 1.26 (0.95 to 1.69) per natural logarithm of CRP (mg/l), respectively. Conclusions Greater early blood CRP moderately increases long-term risk of recurrent cardiovascular events or death, and may be a valuable prognostic predictor in patients after ACS.


Related Articles

  • The inherited real risk of coronary artery disease. Stagnaro, S; Caramel, S // European Journal of Clinical Nutrition;Jun2013, Vol. 67 Issue 6, p683 

    No abstract available.

  • Genotypes associated with CRP elevations. Kuritzky, Louis // Neurology Alert;Jan2009 Clinical Briefs in Primary, Vol. 14 Issue 1, p1 

    This article discusses research being done on genotypes associated with elevated C-reactive proteins (CRPs). It references a study by J. Zacho et al., published in the "New England Journal of Medicine" in 2008. The researchers found that an elevated CRP was associated with an increased risk of...

  • The effect of periodontal therapy on C-reactive protein, endothelial function, lipids and proinflammatory biomarkers in patients with stable coronary artery disease: study protocol for a randomized controlled trial. Lumertz Saffi, Marco Aurélio; Furtado, Mariana Vargas; Montenegro, Márlon Munhoz; Josephson Ribeiro, Ingrid Webb; Kampits, Cassio; Rabelo-Silva, Eneida Rejane; Polanczyk, Carisi Anne; Rösing, Cassiano Kuchenbecker; Haas, Alex Nogueira // Trials;2013, Vol. 14 Issue 1, p1 

    Background: Scarce information exists regarding the preventive effect of periodontal treatment in the recurrence of cardiovascular events. Prevention may be achieved by targeting risk factors for recurrent coronary artery disease (CAD) in patients with previous history of cardiovascular events....

  • C-reactive protein was a moderate predictor of coronary heart disease. Smith, Donald A. // ACP Journal Club;Sep/Oct2004, Vol. 141 Issue 2, p51 

    This article investigates that C-Reactive Protein (CRP) is a moderate predictor of coronary heart disease. 2459 patients (mean age 56 y, 72% men) with major coronary events during mean 17.5-year follow-up were matched for year of recruitment, sex, and age with 3969 patients (mean age 56 y, 69%...

  • Correlation of high-sensitivity C-reactive protein and carotid plaques with coronary artery disease in elderly patients. YANHONG LIANG; YUANPING HOU; HONGYU NIU; MEI LU; LEI XUE; QIANMEI SUN // Experimental & Therapeutic Medicine;2015, Vol. 10 Issue 1, p275 

    The aim of this study was to explore the correlation of high-sensitivity C-reactive protein (hs-CRP) and carotid plaques with the severity of coronary artery disease (CAD). A total of 140 patients with angina who underwent coronary angiography were selected and divided into a single-vessel...

  • Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease. Nissen, Steven E.; Tuzcu, E. Murat; Schoenhagen, Paul; Crowe, Tim; Sasiela, William J.; Tsai, John; Orazem, John; Magorien, Raymond D.; O'Shaughnessy, Charles; Ganz, Peter // New England Journal of Medicine;1/6/2005, Vol. 352 Issue 1, p29 

    Background: Recent trials have demonstrated better outcomes with intensive than with moderate statin treatment. Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers...

  • Periodontitis, C-reactive Protein and Peripheral Blood; Links with Cardiovascular Disease. Rai, Balwant; Kharb, Simmi; Jain, Rajnish; Anand, S. C. // Advances in Medical & Dental Sciences;Sep-Dec2009, Vol. 3 Issue 3, p76 

    C-reactive protein (CRP) is potential marker of cardiovascular risk and has been recently associated with periodontal disease. CRP levels were analyzed in 26 periodontitis patients and 23 healthy controls. Also, hemoglobin, red blood cell count (RBC), leukocyte cell count (WBC total and...

  • HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein. Chan, Kristine Y.; Boucher, Elizabeth S.; Gandhi, Pritesh J.; Silva, Matthew A. // American Journal of Health-System Pharmacy;8/15/2004, Vol. 61 Issue 16, p1676 

    Examines results of clinical trials which evaluated the effectiveness of therapy with hydroxymethylglutaryl-coenzyme A reductase inhibitors for reducing elevated C-reactive protein levels and associated coronary events. Attenuation of atherosclerotic plaque growth by therapy aimed at minimizing...

  • Correlations between Coronary Plaque Tissue Composition Assessed by Virtual Histology and Blood Levels of Biomarkers for Coronary Artery Disease. Young-Guk Ko; Van Cuong Le; Bo Hyun Kim; Dong-Ho Shin; Jung-Sun Kim; Byeong-Keuk Kim; Donghoon Choi; Yangsoo Jang; Myeong-Ki Hong // Yonsei Medical Journal;May2012, Vol. 53 Issue 3, p508 

    Purpose: We investigated correlations of coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and blood levels of biomarkers that represent the vulnerability of coronary plaques. Materials and Methods: Pre- and postprocedural blood levels of high...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics