TITLE

Myocardial deformation in aortic valve stenosis: relation to left ventricular geometry

AUTHOR(S)
Cramariuc, Dana; Gerdts, Eva; Davidsen, Einar Skulstad; Segadal, Leidulf; Matre, Knut
PUB. DATE
January 2010
SOURCE
Heart;Jan2010, Vol. 96 Issue 2, p106
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective To assess left ventricular (LV) strain and displacement and their relations to LV geometry in patients with aortic stenosis (AS). Design Cross-sectional echocardiographic study in patients with AS. Peak circumferential, radial and longitudinal strain, and radial, longitudinal and transverse displacement were measured by 2D speckle tracking. Severity of AS was assessed from energy loss index (ELI). LV hypertrophy was present if LV mass/height2.7 ≥46.7/49.2 g/m2.7 in women/men and concentric LV geometry if relative wall thickness ≥0.43. LV geometry was assessed from LV mass/height2.7 and relative wall thickness in combination. Setting Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. Patients 70 patients with AS (mean age 73±10 years, 54% women). Interventions None. Main outcome measures Association of regional and average LV myocardial strain and displacement with LV geometric pattern and degree of AS. Results Average longitudinal strain was lower in the hypertrophy groups and correlated with higher LV mass index and relative wall thickness, lower stress-corrected mid-wall shortening and smaller ELI (all p<0.05). Average strain and displacement in other directions did not differ between geometric groups. In multivariate regression analysis, lower average longitudinal strain was associated with higher relative wall thickness (β=0.15), lower ejection fraction (β=-0.16), systolic blood pressure (β=-0.16) and energy loss index (β=-0.20) (all p<0.05) (R²=0.72). When relative wall thickness was replaced with LV mass, lower longitudinal strain was also associated with higher LV mass (β=0.21, p<0.05) (R²=0.73). Conclusions In patients with AS, lower average longitudinal strain is related to higher LV mass, concentric geometry and more severe AS.
ACCESSION #
48971502

 

Related Articles

  • Circulating Level of miR-378 Predicts Left Ventricular Hypertrophy in Patients with Aortic Stenosis. Chen, Zhongxiu; Li, Chen; Xu, Yuanning; Li, Yajiao; Yang, Hao; Rao, Li // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Aims: Excessively high left ventricle mass is an independent predictor of adverse prognosis. MicroRNAs (miRs) play crucial roles in the regulation of left ventricle hypertrophy (LVH). However, few circulating miRs have been established as predictors of LVH in aortic stenosis (AS) patients. In...

  • Gender differences in factors influencing electrocardiographic findings of left ventricular hypertrophy in severe aortic stenosis. Satoh, Shinji; Omura, Soichiro; Inoue, Hiroko; Ejima, Emiko; Shimozono, Koutatsu; Hayashi, Makiko; Mori, Takahiro; Takenaka, Katsuhiko; Kawamura, Natsumi; Numaguchi, Kotaro; Mori, Etsuo; Asoh, Akemi; Nakamura, Toshihiro; Hiyamuta, Koji // Heart & Vessels;Sep2014, Vol. 29 Issue 5, p659 

    We investigated gender differences in factors influencing the electrocardiographic (ECG) findings of left ventricular hypertrophy (LVH) in patients with severe aortic stenosis (AS). The functional and geometric responses of the left ventricle to chronic pressure overload, such as hypertension...

  • Evaluation of Diastolic Function in Patients with Aortic Stenosis. Szabados, Cs.; Frigy, A.; Emőke, Baricz; Imola, Szabados; Boglárka, Vecsei; Incze, A. // Acta Medica Marisiensis;Jun2011, Vol. 57 Issue 3, p247 

    Introduction: Diastolic dysfunction is characterized by an increased resistance to filling with increased diastolic filling pressures. Aortic stenosis has become the most frequent type of valvular heart disease. Aortic stenosis increases diastolic filling pressures due left ventricular...

  • Risk factors for post-acute myocardial infarction depression in elderly. Moşuţan, Cristina; Diaconu, Raluca E.; Rădulescu, Maria L.; Şerban, Adela M.; Duncea, Caius R. // Human & Veterinary Medicine;Dec2011, Vol. 3 Issue 3, p220 

    Objective: To determine risk factors for development of post-acute ST elevation myocardial infarction (STEMI) depression in elderly. Material and Methods: We included 104 elderly patients diagnosed with STEMI. Clinical, lab and imagistic data was recorded in the first week after STEMI. Six...

  • Effect of overweight and obesity on the left ventricular systolic and diastolic functions in patients with acute myocardial infarction. Poyraz, Fatih; Turfan, Murat; Kocaman, Sinan A.; Yazici, Huseyin U.; Sen, Nihat; Tulmac, Murat; Vatankulu, Mehmet A.; Aygül, Nazif; Ozdogru, Ibrahim; Aydar, Yuksel; Tavil, Yusuf; Abaci, Adnan // Clinical & Investigative Medicine;2012, Vol. 35 Issue 4, pE229 

    Purpose: The purpose of this study was to evaluate whether a association exits among overweight and obesity and left ventricular systolic and diastolic functions in patients admitted with first ST-elevation myocardial infarction (STEMI). Methods: The present study was performed on 451...

  • A Clinical Rule to Predict Preserved Left Ventricular Ejection Fraction in Patients after Myocardial Infarction. Silver, Marc T.; Rose, Geoffrey A.; Paul, Sumita D.; O'Donnell, Christopher J.; O'Gara, Patrick T.; Eagle, Kim A. // Annals of Internal Medicine;11/15/94, Vol. 121 Issue 10, p750 

    Provides information on a study that derived and validated a clinical prediction rule that identifies patients after myocardial infarction who have presented a left ventricular systolic function. Methodology of the study; Results and discussion on the study.

  • Starting enalapril less than 24 hours after MI lessens LV dilation.  // Modern Medicine;May94, Vol. 62 Issue 5, p53 

    Presents an abstract of the article entitled, `Attenuation of left ventricular dilatation after acute myocardial infarction by early initiation of enalapril therapy,' by V.V.S. Bonarjee, S. Carstensen, K. Caidahl et al as published in the periodical `American Journal of Cardiology' dated...

  • EXERCISE ECHOCARDIOGRAPHY IN ASYMPTOMATIC PATIENTS WITH SEVERE AORTIC STENOSIS AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION. HENRI, CHRISTINE; LANCELLOTTI, PATRIZIO // Journal of Cardiovascular Ultrasound;Mar2014, Vol. 22 Issue 1, p1 

    The management of asymptomatic patients with severe aortic stenosis (AS) remains controversial. Recent series reported that early aortic valve replacement might be associated with improved clinical outcomes. However, the risk-benefit ratio should be carefully evaluated and early surgery only be...

  • Metabolic syndrome and risk for heart failure in middle-aged men. Ingelsson, E.; Ärnl�F6;v, J.; Lind, L.; Sundström, J. // Heart;Oct2006, Vol. 92 Issue 10, p1409 

    Objective: To explore metabolic syndrome as a possible risk factor for development of heart failure (HF). Design: Community-based cohort study. Setting: Uppsala, Sweden. Participants: 2314 50-year-old men free from HF, myocardial infarction and valvular disease at baseline were enrolled between...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics