TITLE

Zirconia based nucleic acid sensor for Mycobacterium tuberculosis detection

AUTHOR(S)
Das, Maumita; Sumana, Gajjala; Nagarajan, R.; Malhotra, B. D.
PUB. DATE
March 2010
SOURCE
Applied Physics Letters;3/29/2010, Vol. 96 Issue 13, p133703
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Nanostructured zirconium oxide (ZrO2) film (particle size∼35 nm), electrochemically deposited onto gold(Au) surface, has been used to immobilize 21-mer oligonucleotide probe (ssDNA) specific to Mycobacterium tuberculosis by utilizing affinity between oxygen atom of phosphoric group and zirconium to fabricate DNA biosensor. This DNA-ZrO2/Au bioelectrode, characterized using x-ray diffraction, Fourier transform infrared spectroscopy, cyclic voltammetry, and scanning electron microscopy techniques, can be used for early and rapid diagnosis of M. tuberculosis with detection limit of 0.065 ng/μL within 60s.
ACCESSION #
48943869

 

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