TITLE

Physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution

AUTHOR(S)
Moriyama, Brad; Henning, Stacey A.; Haksong Jin; Kolf, Michael; Rehak, Nadja N.; Danner, Robert L.; Walsh, Thomas J.; Grimes, George J.
PUB. DATE
April 2010
SOURCE
American Journal of Health-System Pharmacy;4/1/2010, Vol. 67 Issue 7, p562
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose. The physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution was assessed. Methods. Two bicarbonate-buffered hemofiltration solutions (low- and highmagnesium formulations) were compounded in triplicate. The concentrations of magnesium (15 meq/L) and sodium bicarbonate (50 meq/L) in the high-magnesium formulation were chosen to be somewhat below the concentrations reported as being incompatible in a popular reference. The six hemofiltration bags were stored at 22-25 °C without protection from light for 48 hours. Physical compatibility was assessed by visual inspection and microscopy. The pH of the solutions was assayed 3-4 and 52-53 hours after compounding. Electrolyte and glucose concentrations of the solutions were assayed at 3-4 and 50-51 hours after preparation. Results. No particulate matter was observed by visual or microscopic inspection in the compounded hemofiltration solutions at 48 hours. The mean ± S.D. pH values of the low-magnesium solutions were 8.01 ± 0.02 and 8.04 ± 0.02 at 3-4 and 52-53 hours after compounding, respectively. The mean ± S.D. pH values of the high-magnesium solutions were 7.96 ± 0.02 and 7.98 ± 0.01 at 3-4 and 52-53 hours after compounding, respectively. The electrolyte and glucose concentrations in the low- and high-magnesium solutions were similar 3-4 and 50-51 hours after preparation. Conclusion. Magnesium sulfate 1.5 meq/L and sodium bicarbonate 50 meq/L were physically compatible in a pharmacycompounded hemofiltration solution for 48 hours when stored at 22-25 °C without protection from light.
ACCESSION #
48911296

 

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