Physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution

Moriyama, Brad; Henning, Stacey A.; Haksong Jin; Kolf, Michael; Rehak, Nadja N.; Danner, Robert L.; Walsh, Thomas J.; Grimes, George J.
April 2010
American Journal of Health-System Pharmacy;4/1/2010, Vol. 67 Issue 7, p562
Academic Journal
Purpose. The physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution was assessed. Methods. Two bicarbonate-buffered hemofiltration solutions (low- and highmagnesium formulations) were compounded in triplicate. The concentrations of magnesium (15 meq/L) and sodium bicarbonate (50 meq/L) in the high-magnesium formulation were chosen to be somewhat below the concentrations reported as being incompatible in a popular reference. The six hemofiltration bags were stored at 22-25 °C without protection from light for 48 hours. Physical compatibility was assessed by visual inspection and microscopy. The pH of the solutions was assayed 3-4 and 52-53 hours after compounding. Electrolyte and glucose concentrations of the solutions were assayed at 3-4 and 50-51 hours after preparation. Results. No particulate matter was observed by visual or microscopic inspection in the compounded hemofiltration solutions at 48 hours. The mean ± S.D. pH values of the low-magnesium solutions were 8.01 ± 0.02 and 8.04 ± 0.02 at 3-4 and 52-53 hours after compounding, respectively. The mean ± S.D. pH values of the high-magnesium solutions were 7.96 ± 0.02 and 7.98 ± 0.01 at 3-4 and 52-53 hours after compounding, respectively. The electrolyte and glucose concentrations in the low- and high-magnesium solutions were similar 3-4 and 50-51 hours after preparation. Conclusion. Magnesium sulfate 1.5 meq/L and sodium bicarbonate 50 meq/L were physically compatible in a pharmacycompounded hemofiltration solution for 48 hours when stored at 22-25 °C without protection from light.


Related Articles

  • Original Andrews Salts.  // Royal Society of Medicine: Medicines;2002, p413 

    The article presents information on Original Andrew Salts which is a proprietary, non-prescription compound preparation of the antacid sodium bicarbonate and the laxative magnesium sulphate (and citric acid). It can be used to relieve upset stomach, indigestion, symptoms of overindulgence and...

  • Hypothermic overdose, not all bad? Petterson, Timothy; Lyon, Lindsay; Peckler, Bradley // Journal of Emergencies, Trauma & Shock;Jul-Sep2013, Vol. 6 Issue 3, p227 

    A 51-year-old woman was brought into the Emergency Department (ED) following an intentional overdose of alcohol and her medication. Along with two bottles of wine it was estimated that she had taken 5800 mg of Quetiapine and 240 mg of Citalopram along with the wine. The ambient temperature in...

  • Sodium Bicarbonate, BP.  // Royal Society of Medicine: Medicines;2002, p499 

    The article provides information on the therapeutic application of sodium bicarbonate as an antacid. It is available as a solution.

  • Estudio comparativo entre diferentes diluciones de lidocaína-bicarbonato de sodio en infiltración local para la colocación del anillo de estereotaxia. Moreno-Jiménez, Sergio; Rangel, Alejandra Ibarra; Zárate, Carmelita Loaeza; Aceves, Guillermo Axayacalt Gutiérrez; Celis, Miguel Angel; Terrazo-Lluch, Javier; Reyes-Moreno, Ignacio // Archivos de Neurociencias;ene-mar2008, Vol. 13 Issue 1, p3 

    The infiltration of solutions of lidocain with epinephrin are painful for the patient. Different methods have been studied to reduce pain like buffered solutions with sodium bicarbonate or the infiltration of warm solutions. Published reports include the analysis of pain in the face and...

  • Advances in toxicology and medical treatment of chemical warfare nerve agents. Moshiri, Mohammd; Darchini-Maragheh, Emadodin; Balali-Mood, Mahdi // DARU;2012, Vol. 20, p1 

    Organophosphorous (OP) Nerve agents (NAs) are known as the deadliest chemical warfare agents. They are divided into two classes of G and V agents. Most of them are liquid at room temperature. NAs chemical structures and mechanisms of actions are similar to OP pesticides, but their toxicities are...

  • COMPARISON OF NO VERSUS HEPARIN ANTICOAGULATION DURING CRRT. Soni, Sachin; Barnela, Sriganesh; Nagarik, Amit P.; Kishan, A. Gopal; Anuradha // Indian Journal of Nephrology;Jul-Sep2007, Vol. 17 Issue 3, p124 

    Systemic heparinisation during CRRT is associated with well known disadvantages especially in those with deranged coagulation profile. We carried out this study to analyse efficacy of no-anticoagulation (frequent saline flushings) compared with heparin anticoagulation in CRRT. Materials and...

  • Amitriptyline/trimipramine overdose.  // Reactions Weekly;3/3/2007, Issue 1141, p6 

    The article presents a case study of an intentional overdose of ingested amitriptyline and trimipramine in a suicide attempt by a 28-year-old man. He was admitted to the intensive care unit 3 hours later. His treatment included sodium bicarbonate and physostigmine, activated charcoal, magnesium...

  • How safe are compounded IVs? Beyzarov, Elena // Drug Topics;9/18/2006, Vol. 150 Issue 18, special section p1 

    The article presents an opinion regarding a debate over the safety of compounded intravenous solutions for critical care in a hospital setting. The "USA Today" periodical highlighted Fredericksburg, Virginia-based Mary Washington Hospital's ordeal in which cardiac surgery patients were injected...

  • Multipurpose baking soda. Bauman, Richard // Country Journal;Sep/Oct93, Vol. 20 Issue 5, p18 

    Discusses various uses for sodium bicarbonate or baking soda. Baking; Oral hygiene; Relieving acid ingestion and an upset stomach; All-purpose cleaner; Removal of corrosion; Removal of odors; Dousing of grease fires.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics