Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress

Balkan, J.; Dogru-Abbasoglu, S.; Kanbagli �.; �evikbas, U.; Ayka�-Toker, G.; Uysal, M.
May 2001
Human & Experimental Toxicology;May2001, Vol. 20 Issue 5, p251
Academic Journal
Thioacetamide (TAA) administration (0.3 g/l of tap water for a period of 3 months) to rats resulted in hepatic cirrhosis as assessed by biochemical and histopathological findings. This treatment caused an increase in the levels of malondialdehyde (MDA) and diene conjugates (DCs) and a decrease in the levels of glutathione (GSH), vitamin E, vitamin C and the activities of glutathione peroxidase (GSH-Px) in the liver of rats. Superoxide dismutase (SOD) activities were unchanged. Taurine (2% w/w, added to the chow diet) was administered together with TAA (0.3 g/l of drinking water) for 3 months. Taurine was found to decrease TAA-induced hepatic lipid peroxidation and to increase TAA-depleted vitamin E levels and GSH-Px activities. Histopathological findings also suggested that taurine has an inhibitive effect on TAA-induced hepatic cirrhosis. These results indicate that taurine treatment has a protective effect against TAA-induced liver cirrhosis by decreasing oxidative stress. Human & Experimental Toxicology (2001) 20, 251�254.


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