Inhaled Mometasone Furoate: A Review of its Use in Adults and Adolescents with Persistent Asthma

Sharpe, M.; Jarvis, B.
July 2001
Drugs;Jul2001, Vol. 61 Issue 9, p1325
Academic Journal
Mometasone furoate is a corticosteroid with relatively high in vitro potency. Recent randomised, double-blind, multicentre trials have assessed the efficacy of mometasone furoate delivered by dry powder inhaler over 12 weeks in adults and adolescents with mild to severe persistent asthma. Mometasone furoate 200µg twice daily or 400µg once daily in the morning or 200µg once daily in the evening improved lung function, asthma symptom scores and use of rescue medication to a significantly greater extent than placebo in patients who had previously received only short-acting inhaled β-adrenoceptor agonists alone as treatment in 3 trials (n = 195 to 306). In studies in 227 to 733 patients with mild to moderate asthma who were receiving ongoing treatment with inhaled corticosteroids prior to enrolment, mometasone furoate 100 to 400µg twice daily was consistently better at improving the above indicators of asthma than placebo. Mometasone furoate 100 to 200µg twice daily was as effective as beclomethasone dipropionate 200µg twice daily or budesonide 400µg twice daily and mometasone furoate 200µg twice daily was as effective as fluticasone propionate 250µg twice daily. Mometasone furoate 400 or 800µg twice daily was also consistently more effective than placebo in reducing oral corticosteroid dosages and improving lung function and asthma symptoms in 132 patients with oral corticosteroid-dependent asthma. Once daily administration of mometasone furoate 400µg appears to be as effective at improving indicators of asthma as twice daily administration of 200µg. Patients receiving mometasone furoate ≤800 µg/day and recipients of placebo experienced a similar overall incidence of adverse events considered to be related to treatment. The most common of these events were oral candidiasis, headache, pharyngitis and dysphonia. Mometasone furoate 100 to 400µg twice daily, beclomethasone dipropionate 200µg twice daily, budesonide 400µg twice daily or fluticasone propionate 250µg twice daily were similarly tolerated. Conclusion: Inhaled mometasone furoate is well tolerated, with minimal systemic activity and is equally effective when administered as a divided dose or as a single daily dose. Use of the drug can result in a decrease in requirements for oral corticosteroids in patients with oral corticosteroid-dependent asthma and is as effective as other inhaled corticosteroids currently used in the treatment of mild to moderate persistent asthma. Thus mometasone furoate is suitable for the control of mild to severe persistent asthma in adults or adolescents.



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