Tamoxifen, raloxifene, and tibolone prevent primary invasive breast cancer but increase risk for adverse outcomes

Melnikow, Joy
March 2010
ACP Journal Club;3/16/2010, Vol. 152 Issue 3, p3
Academic Journal
The article focuses on a study related to the effectiveness of tamoxifen, raloxifene, and tibolone in reducing the risk of breast cancer in women without preexisting breast cancer. Study compared tamoxifen, raloxifene, or tibolone with placebo in the prevention of breast cancer. It concludes that in women without preexisting breast cancer, all three drugs can prevent invasive breast cancer and reduce risk for fractures but increase risk for thromboembolic events, stroke and endometrial cancer.


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