TITLE

Maximal Exercise Electrocardiographic Responses and Coronary Heart Disease Mortality Among Men With Metabolic Syndrome

AUTHOR(S)
Lyerly, G. William; Xuemei Sui; Church, Timothy S.; Lavie, Carl J.; Hand, Gregory A.; Blaire, Steven N.
PUB. DATE
March 2010
SOURCE
Mayo Clinic Proceedings;Mar2010, Vol. 85 Issue 3, p239
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To examine the association between abnormal exercise electrocardiographic (E-ECG) test results and mortality (all-cause and that resulting from coronary heart disease [CHD] or cardiovascular disease [CVD]) In a large population of asymptomatic men with metabolic syndrome (MetS). PATIENTS AND METHODS: A total of 9191 men (mean age, 46.9 years) met the criteria of having MetS. All completed a maximal E-ECG treadmill test (May 14, 1979, through April 9, 2001) and were without a previous CVD event or diabetes at baseline. Main outcomes were all-cause mortality, mortality due to CHD, and mortality due to CVD. Cox regression analysis was used to quantify the mortality risk according to E-ECG responses. RESULTS: During a follow-up of 14 years, 633 deaths (242 CVD and 150 CHD) were identified. Mortality rates and hazard ratios (HRs) across E-ECG responses were the following: for all-cause mortality: HR, 1.36; 95% confidence interval (CI), 1.09-1.70 for equivocal responses and HR, 1.41; 95% CI, 1.12-1.77 for abnormal responses (Ptrend <.001); for mortality due to CVD: HR, 129; 95% CI, 0.88-1.88 for equivocal responses and HR, 2.04; 95% CI, 1.46-2.84 for abnormal responses (Ptrend <.001); and for mortality due to CHD: HR, 1.62; 95% CI, 1.02-2.56 for equivocal responses and HR, 2.45; 95% CI, 1.62-3.69 for abnormal responses (Ptrend <.001). A positive gradient for CHD, CVD, and all-cause mortality rates across E-ECG categories within 3, 4, or 5 MetS components was observed (P<.001 for all). CONCLUSION: Among men with MetS, an abnormal E-ECG response was associated with higher risk of all-cause, CVD, and CHD mortality. These findings underscore the importance of E-ECG tests to identify men with MetS who are at risk of dying.
ACCESSION #
48806852

 

Related Articles

  • Risk Associated With the Metabolic Syndrome Versus the Sum of Its Individual Components. Sundström, Johan; Vallhagen, Erik; Berne, Christian; Risérus, Ulf; Byberg, Liisa; Zethelius, Björn; Ingelsson, Erik; Lind, Lars // Diabetes Care;Jul2006, Vol. 29 Issue 7, p1673 

    The article presents the results of a case study regarding the risk associated with the metabolic syndrome versus the sum of its individual components. The study found that metabolic syndrome did not provide risk information above and beyond its individual components. The metabolic syndrome...

  • ECGs Should Be Replaced. George, Hank // Best's Review;Sep2013, Vol. 114 Issue 5, p28 

    The article compares the efficiency of the NT-proBNP cardiac marker over the electrocardiography (ECG). It mentions that NT-proBNP can detect the risk factors of cardiac diseases compared to ECG which misses cases of the disorders by 50%. It notes that the link of elevated NT-proBNP with heart...

  • Cardiac Screening With Electrocardiography, Stress Echocardiography, or Myocardial Perfusion Imaging.  // Annals of Internal Medicine;3/17/2015, Vol. 162 Issue 6, pI-38 

    The article focuses on cardiac screening through electrocardiography, stress echocardiography and myocardial perfusion imaging. Topics include use of cardiac screening tests in predicting the risk for heart disease, risks of screening tests such as exposure to radiation and reaction to an...

  • Early Repolarization Syndrome- to Be or Not to Be Benign. Enescu, Oana; Cinteza, Mircea; Vinereanu, Dragos // Maedica - a Journal of Clinical Medicine;2011, Vol. 6 Issue 3, p215 

    The early repolarization syndrome, particular electrocardiographic aspect defined as J point and concave ST segment elevation, interpreted by electrophysiologists as benign for over five decades, caused over the past three years many controversies. The trigger for controversy were the results of...

  • Diagnosis of cardiac disease in pediatric end-stage renal disease. Chavers, Blanche M.; Solid, Craig A.; Sinaiko, Alan; Daniels, Frank X.; Chen, Shu-Cheng; Collins, Allan J.; Frankenfield, Diane L.; Herzog, Charles A. // Nephrology Dialysis Transplantation;May2011, Vol. 26 Issue 5, p1640 

    Background. Cardiac disease is a significant cause of morbidity and mortality in children with end-stage renal disease (ESRD). This study aimed to report the frequency of cardiac disease diagnostic methods used in US pediatric maintenance hemodialysis patients.Methods. A cross-sectional analysis...

  • Necrotic Bowel Induces Takotsubo-Like Myocardial Injury. Koci, Florian; Eltibi, Rami; Hadley, Michelle; Kumar, Deepti // Texas Heart Institute Journal;Dec2014, Vol. 41 Issue 6, p638 

    Although chest pain in association with ST-segment electrocardiographic deviation is often indicative of cardiac ischemia, it has also been associated with noncardiac conditions. The case of a 63-year-old woman that we report here is extraordinary because her presentation of "acute abdomen" did...

  • Accuracy of advanced versus strictly conventional 12-lead ECG for detection and screening of coronary artery disease, left ventricular hypertrophy and left ventricular systolic dysfunction. Schlegel, Todd T.; Kulecz, Walter B.; Feiveson, Alan H.; Greco, E. Carl; DePalma, Jude L.; Starc, Vito; Vrtovec, Bojan; Rahman, M. Atiar; Bungo, Michael W.; Hayat, Matthew J.; Bauch, Terry; Delgado, Reynolds; Warren, Stafford G.; Núñez-Medina, Tulio; Medina, Rubén; Jugo, Diego; Arheden, Håkan; Pahlm, Olle // BMC Cardiovascular Disorders;2010, Vol. 10, p28 

    Background: Resting conventional 12-lead ECG has low sensitivity for detection of coronary artery disease (CAD) and left ventricular hypertrophy (LVH) and low positive predictive value (PPV) for prediction of left ventricular systolic dysfunction (LVSD). We hypothesized that a ~5-min resting...

  • Comparative Mortality in Asymptomatic Men Issued Standard Insurance with Routine ECG Classified as Normal or with Minor T Wave Changes. Singer, Richard B. // Journal of Insurance Medicine;2008, Vol. 40 Issue 3/4, p186 

    Methods.—From a prospective electrocardiogram (ECG) study file at the New England Mutual Life Insurance Company, cases were selected on the basis of men issued standard insurance, without symptoms, but with a routine ECG interpreted as normal or with minor low amplitude T wave (+0.5 mm to...

  • Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography. Okayama, Satoshi; Soeda, Tsunenari; Kawakami, Rika; Takami, Yasuhiro; Somekawa, Satoshi; Ueda, Tomoya; Sugawara, Yu; Matsumoto, Takaki; Sung, Ji; Nishida, Taku; Uemura, Shiro; Saito, Yoshihiko // Heart & Vessels;Jan2015, Vol. 30 Issue 1, p28 

    Coronary artery disease and cardiac morphology and function were evaluated in 51 patients with hypertrophic cardiomyopathy (HCM), without typical chest pain, using cardiac computed tomography (CT). This study investigated the prevalence of coronary artery disease, the indicators of obstructive...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics