TITLE

Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients

AUTHOR(S)
Polasek, Ozren; Gunjaca, Grgo; Kolcvic, Ivana; Zgaga, Lina; Dzijan, Snjezana; Smolic, Robert; Smolic, Martina; Milas-Ahic, Jasminka; Seric, Vatroslav; Galic, Josip; Tucak-Zoric, Sandra; Tucak, Antun; Rudan\, Igor; Lauc, Gordan
PUB. DATE
February 2010
SOURCE
Croatian Medical Journal;Feb2010, Vol. 51 Issue 1, p48
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9. Methods A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267). Results There was a weak but significant association of all 4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006 for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance. Conclusion Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.
ACCESSION #
48722224

 

Related Articles

  • A functional polymorphism of the µ-opioid receptor gene is associated with completed suicides. Hishimoto, A.; Cui, H.; Mouri, K.; Nushida, H.; Ueno, Y.; Maeda, K.; Shirakawa, O. // Journal of Neural Transmission;Mar2008, Vol. 115 Issue 3, p531 

    A recent linkage study suggested that a putative locus for suicidal behavior independent of psychiatric disease phenotypes lies at 5′ upstream of the µ-opioid receptor ( OPRM1) gene. We explored an association between suicide and genetic variations of the OPRM1 using a case-control...

  • Role of IFN-γ +874 T/A single nucleotide polymorphism in the tuberculosis outcome among Brazilians subjects. Lucia Amim; Antonio Pacheco; Joseane Fonseca-Costa; Carla Loredo; Marcelo Rabahi; Maria Melo; Fernando Ribeiro; Fernanda Mello; Martha Oliveira; José Lapa e Silva; Tom Ottenhoff; Afrânio Kritski; Adalberto Santos // Molecular Biology Reports;Dec2008, Vol. 35 Issue 4, p563 

    Abstract  Several genetic cytokine gene variants have been associated with host susceptibility to infectious diseases, including tuberculosis. Based upon the importance of IFN-γ in protective immunity against Mycobacterium tuberculosis, and the functional role of the...

  • A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population. Ma, Lan; Zhu, Lingjun; Gu, Dongying; Chu, Haiyan; Tong, Na; Chen, Jinfei; Zhang, Zhengdong; Wang, Meilin // Archives of Toxicology;May2013, Vol. 87 Issue 5, p825 

    MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In...

  • Using Cases and Parents to Study Multiplicative Gene-by-Environment Interaction. Kistner, Emily O.; Min Shi; Weinberg, Clarice R. // American Journal of Epidemiology;Aug2009, Vol. 170 Issue 3, p393 

    With case-parent triads, one can estimate genotype relative risks by measuring the apparent overtransmission of susceptibility genotypes from parents to affected offspring. Results obtained using such designs, properly analyzed, resist both bias due to population structure and bias due to...

  • DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers. Radwan, Ghada N.; Setouhy, Maged El-; Mohamed, Mostafa K.; Hamid, Mohamed Abdel; Israel, Ebenezer; Azem, Salwa Abdel; Kamel, Omima; Loffredo, Christopher A. // Nicotine & Tobacco Research;Dec2007, Vol. 9 Issue 12, p1325 

    Little is known about the genetic contribution to cigarette smoking and nicotine addiction in Egypt. The dopamine D2 receptor gene contains a TaqI repeat fragment length polymorphism creating two alleles with functional significance, DRD2*A1 and DRD2*A2. We investigated the relationship between...

  • Clinical and Functional Characterization of URAT1 Variants. Tasic, Velibor; Hynes, Ann Marie; Kitamura, Kenichiro; Cheong, Hae Il; Lozanovski, Vladimir J.; Gucev, Zoran; Jutabha, Promsuk; Anzai, Naohiko; Sayer, John A. // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Idiopathic renal hypouricaemia is an inherited form of hypouricaemia, associated with abnormal renal handling of uric acid. There is excessive urinary wasting of uric acid resulting in hypouricaemia. Patients may be asymptomatic, but the persistent urinary abnormalities may manifest as renal...

  • Reaction wood - a key cause of variation in cell wall recalcitrance in willow. B. Brereton, Nicholas J.; Ray, Michael J.; Shield, Ian; Martin, Peter; Karp, Angela; Murphy, Richard J. // Biotechnology for Biofuels;2012, Vol. 5 Issue 1, p83 

    Background: The recalcitrance of lignocellulosic cell wall biomass to deconstruction varies greatly in angiosperms, yet the source of this variation remains unclear. Here, in eight genotypes of short rotation coppice willow (Salix sp.) variability of the reaction wood (RW) response and the...

  • Interactions Between Genotype and Depressive Symptoms on Obesity. Fuemmeler, Bernard F.; Agurs-Collins, Tanya; McClernon, F. Joseph; Kollins, Scott H.; Garrett, Melanie E.; Ashley-Koch, Allison E. // Behavior Genetics;May2009, Vol. 39 Issue 3, p296 

    Depression and Genetic variation in serotonin and monoamine transmission have both been associated with body mass index (BMI), but their interaction effects are not well understood. We examined the interaction between depressive symptoms and functional polymorphisms of serotonin transporter...

  • Potentially functional polymorphisms in the ERCC2 gene and risk of Esophageal Squamous Cell Carcinoma in Chinese populations. Mei-Ling Zhu; Jing He; MengYun Wang; Meng-Hong Sun; Li Jin; Xiaofeng Wang; Ya-Jun Yang; Jiu-Cun Wang; Leizhen Zheng; Jia-Qing Xiang; Qing-Yi Wei // Scientific Reports;9/12/2014, p1 

    ERCC2 is indispensable for nucleotide excision repair pathway, and its functional polymorphisms may be associated with cancer risk. In a large case-control study of 1126 esophageal squamous cell carcinomas (ESCC) patients and 1131 controls, we genotyped two SNPs inERCC2 (rs238406 G.T and rs13181...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics