Contribution of nasal biopsy to leprosy diagnosis

Naves, Marcell Melo; Patrocinio, Lucas Gomes; Patrocinio, José Antonio; Mota, Flávia Marques Naves; de Souza, Antônio Diniz; Fleury, Raul Negrão; Goulart, Isabela Maria Bernardes
March 2009
American Journal of Rhinology & Allergy;Mar2009, Vol. 23 Issue 2, p177
Academic Journal
Background: The nasal mucosa plays the main role as the entry and the exit of leprosy bacilli and the nasal involvement may precede the skin lesions by several years. Nasal biopsy has been used in research but its clinical application has not been described. We evaluated the contribution of the nasal biopsy for the diagnosis of leprosy and its correlation to skin biopsy and skin smear in untreated patients. Methods: We evaluated changes in nasal biopsy in 227 leprosy patients. Patients were clinically classified and skin and nasal biopsies and skin smear were performed. Results: Nasal biopsy showed positivity in 100% of the lepromatous spectrum decreasing toward the tuberculoid (TT) pole. Patients with TT or indeterminate forms did not present any nasal alterations, showing that they are the true paucibacillary forms. Also, the nasal biopsies of two patients were the only exam to show positivity. The bacillary index of the nasal biopsy was strongly correlated to skin biopsy and slit-skin smear. Additionally, the agreement among the exams was good, revealing the reliability of the nasal biopsy in leprosy diagnosis. Conclusion: The present study showed a rate of 48% of positivity in nasal biopsy of untreated patients, correlating well with skin biopsy and skin smear. Thus, the method in leprosy diagnosis and clinical form classification has shown great reliability.


Related Articles

  • The Effect of a Hyaluronic Acid--Based Nasal Pack on Mucosal Healing in a Sheep Model of Sinusitis. Rajapaksa, Suresh P.; Cowin, Allison; Adams, Damian; Wormald, Peter-John // American Journal of Rhinology;Nov/Dec2005, Vol. 19 Issue 6, p572 

    Background: A hyaluronic acid-based nasal pack has been shown previously to have a beneficial effect on mucosal healing in a healthy sheep model. However, endoscopic sinus surgery (ESS) usually is performed in the presence of infection and inflammation. The aim of this study was to examine the...

  • The Effect of an Expandable Polyvinyl Acetate (Merocel) Pack on the Healing of the Nasal Mucosa of Sheep. McIntosh, David; Cowin, Allison; Adams, Damian; Wormald, Peter-John // American Journal of Rhinology;Nov/Dec2005, Vol. 19 Issue 6, p577 

    Background: There is a lack of knowledge about the healing of the nasal respiratory mucosa after endoscopic sinus surgery (ESS). Nasal packs often are placed after ESS in an attempt to improve hemostasis and reduce adhesion formation. Most nasal packs need to he removed in the postoperative...

  • Looking after local nasal and sinus mucosa in health, disease and after surgery. Kacker, S. // Indian Journal of Otolaryngology & Head & Neck Surgery;Jul-Sep2010, Vol. 62 Issue 3, p258 

    The paper emphasises the need for looking after of nasal and sinus mucosa in health, disease and after nasal surgery. It is a systematic arrangement of steps required to restore nasal mucosa to healthy state. These steps have been arranged to co relate them to diseases and symptoms for...

  • Inmunohistochemical Evaluation of Estrogen Receptors Alpha and Beta in Normal Inferior Turbinate Mucosa. Millas, Ieda; Liquidato, Bianca Maria; Lutaif Dolci, José Eduardo; Macéa, José Rafael; Fregnani, José Humberto Tavares Guerreiro; Meceles, Lenira Rocha // International Journal of Morphology;2010, Vol. 28 Issue 1, p143 

    It has been postulated that the nasal mucosa, like other human tissues, is affected by a complex interactive network of neuropeptides, cytokines, allergic and inflammatory mediators and hormones such as estrogen, in which associations between symptoms (e.g. nasal stuffiness and coryza) and...

  • Lateral nasal osteotomy: a comparative study between the use of osteotome and a diamond surgical burr - a cadaver study. Ghassemi, Alireza; Ayoub, Ashraf; Modabber, Ali; Bohluli, Behnam; Prescher, Andreas // Head & Face Medicine;2013, Vol. 9 Issue 1, p2 

    Background The ultimate goal of rhinoplasty is to achieve a controllable, reliable and an aesthetically pleasing result. Various approaches and instruments have been introduced for the correction of the bony walls of the nose to improve predictability of the procedure and to minimize the...

  • Effects of the Nasal Muscles on the Nasal Airway. Kienstra, Matthew A.; Gassner, Holger G.; Sherris, David A.; Kern, Eugene B. // American Journal of Rhinology;Jul/Aug2005, Vol. 19 Issue 4, p375 

    Background: The nasal muscles and their function are not clearly defined. The nasal muscles generally are thought to act synergistically to produce mimetic motion and affect the nasal airway. We proposed direct examination of the effects of the nasal muscles on the nasal airway. Methods:...

  • Unilateral choanal atresia. Booth, A. P.; Drake-Lee, A. B. // Journal of the Royal Society of Medicine;Oct1991, Vol. 84 Issue 10, p622 

    The article presents the case report of a patient with unilateral choanal atresia, which is considered to be a congenital obstruction of the posterior nose or choana. The patient was presented with a history of mucoid discharge from her right nostril with nasal obstruction. A blockage at the...

  • Leprosy presenting as immune reconstitution inflammatory syndrome. Mehta, Sujata; Padhiar, Bela; Shah, Bela // Indian Journal of Sexually Transmitted Diseases;2008, Vol. 29 Issue 2, p96 

    A 35-year-old HIV-reactive female presented to us with multiple erythematous plaques on her face, trunk, and limbs, since five days. Bilateral ulnar and lateral popliteal nerves were thickened and tender. Antiretroviral drugs (d4T, 3TC, NVP) had been started one month prior. Slit skin smear was...

  • GP Clinical: Common mycobacterial infections. Watkins, Jean // GP: General Practitioner;9/16/2005, p52 

    The article provides information on common microbial infections. A young woman was presented with a weeping, ulcerated area on the left side of her neck. Under the scrofuloderma, grossly enlarged cervical glands could be felt. Biopsy and culture of the glands confirmed the presence of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics