The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact

Schröttner, Percy; Leick, Marion; Burger, Meike
May 2010
Annals of Hematology;May2010, Vol. 89 Issue 5, p437
Academic Journal
Chemokines are centrally involved in leukocyte migration, homing and haematopoiesis. Besides these physiological aspects, their role in pathological processes especially with respect to solid tumour and haematological neoplasias is well established. In this context, the focus was set here on disclosing their contribution in B cell chronic lymphocytic leukaemia (B-CLL), which is regarded as the most characteristic low-grade lymphoma. Up to now, it has been demonstrated that several chemokines are involved in migration of B-CLL cells to lymph nodes, secondary lymphoid organs and bone marrow. Moreover, some chemokines are known to have an anti-apoptotic effect and thus contribute to the survival of B-CLL cells. By interfering with both of these aspects, new therapeutic targets for this yet incurable disease may be developed. Furthermore, a correlation can be drawn between the concentration of some chemokines in patients’ serum, the expression of their respective receptors on B-CLL cells and well-established predictive clinical parameters. Consequently, further systematic investigation of the chemokine network may lead to the identification of new diagnostic and prognostic markers. This review focuses on the impact of chemokines and their receptors on B-CLL pathophysiology and points out potential implications for both treatment and diagnosis.


Related Articles

  • Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines? Scarfò, L; Zibellini, S; Tedeschi, A; Maura, F; Neri, A; Bertazzoni, P; Sarina, B; Nalli, G; Motta, M; Rossini, F; Cortelezzi, A; Montillo, M; Orlandi, E; Ghia, P // Leukemia (08876924);Jul2012, Vol. 26 Issue 7, p1703 

    The article examines whether B-cell count and imaging screening can affect clinical monoclonal B-cell lymphocytosis (cMBL). It analyzes a cohort of 684 patients who were diagnosed with Rai stage 0 chronic lymphosytic leukemia (CLL) or cMBL. It supports the recommendation of the guidelines which...

  • A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment. Ferretti, E.; Bertolotto, M.; Deaglio, S.; Tripodo, C.; Ribatti, D.; Audrito, V.; Blengio, F.; Matis, S.; Zupo, S.; Rossi, D.; Ottonello, L.; Gaidano, G.; Malavasi, F.; Pistoia, V.; Corcione, A. // Leukemia (08876924);Aug2011, Vol. 25 Issue 8, p1268 

    Several chemokines/chemokine receptors such as CCR7, CXCR4 and CXCR5 attract chronic lymphocytic leukemia (CLL) cells to specific microenvironments. Here we have investigated whether the CX3CR1/CX3CL1 axis is involved in the interaction of CLL with their microenvironment. CLL cells from 52...

  • Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells. Semichon, M; Merle-Béral, H; Lang, V; Bismuth, G // Leukemia (08876924);Nov97, Vol. 11 Issue 11, p1921 

    One characteristic of B cells that accumulate during chronic lymphocytic leukemia (CLL) is their highly heterogeneous functional responses to B cell receptor (BCR) stimulation. Leukemic B cells with very poor responses have defective rapid tyrosine phosphorylation of numerous substrates,...

  • Expression of AIF and HtrA2/Omi in Small Lymphocytic Lymphoma and Diffuse Large B-Cell Lymphoma. Li, Shaoying; Wan, Mei; Cao, Xu; Ren, Yongsheng // Archives of Pathology & Laboratory Medicine;Jul2011, Vol. 135 Issue 7, p903 

    Context.--The pathogenesis of non-Hodgkin lymphoma may involve deregulation of apoptosis. In response to apoptotic stimuli, several proapoptotic proteins are released into the cytoplasm from the mitochondria, including second mitochondria-derived activator of caspases/direct inhibitor of...

  • Chronic Lymphocytic Leukemia: Insights from Lymph Nodes & Bone Marrow and Clinical Perspectives. Jakšić, Ozren; Kardum-Skelin, Ika; Jakšić, Branimir // Collegium Antropologicum;Mar2010, Vol. 34 Issue 1, p309 

    B-cell chronic lymphocytic leukemia (B-CLL) is characterized by highly variable distribution of tumor mass between peripheral blood, bone marrow and lymphoid organs which is important for staging, classification and prognosis. These clinical findings with novel data about importance of B-cell...

  • The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia. Giannopoulos, K.; Mertens, D.; Bühler, A.; Barth, T. F. E.; Idler, I.; Möller, P.; Kröber, A.; Greiner, J.; Chocholska, S.; Dmoszyñska, A.; Roliñski, J.; Döhner, H.; Stilgenbauer, S.; Schmitt, M. // Leukemia (08876924);Mar2009, Vol. 23 Issue 3, p519 

    Differential expression of molecules in chronic lymphocytic leukemia (CLL) may define prognostic markers and suitable targets for immunotherapy. Expression of the tumor-associated antigen (TAA) RHAMM (receptor for hyaluronic acid-mediated motility) as well as RHAMM splicing variants was assessed...

  • BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia. Haerzschel, Andrea; Catusse, Julie; Hutterer, Evelyn; Paunovic, Manuela; Zirlik, Katja; Eibel, Hermann; Krenn, Peter; Hartmann, Tanja; Burger, Meike; Krenn, Peter W; Hartmann, Tanja N // Annals of Hematology;Dec2016, Vol. 95 Issue 12, p1979 

    Dysregulation of B cell receptor (BCR) signalling is a hallmark of chronic lymphocytic leukaemia (CLL) pathology, and targeting BCR pathway kinases has brought great therapeutic advances. Activation of the BCR in lymphoid organs has been associated with CLL cell proliferation and survival,...

  • The functional in vitro response to CD40 ligation reflects a different clinical outcome in patients with chronic lymphocytic leukemia. Scielzo, C; Apollonio, B; Scarfò, L; Janus, A; Muzio, M; ten Hacken, E; Ghia, P; Caligaris-Cappio, F // Leukemia (08876924);Nov2011, Vol. 25 Issue 11, p1760 

    Malignant B lymphocytes from chronic lymphocytic leukemia (CLL) patients maintain the capacity to respond to CD40 ligation, among other microenvironmental stimuli. In this study, we show that (i) leukemic CLL cells stimulated with the soluble form of CD40L in vitro show differential responses in...

  • Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Ghobrial, Irene M.; Bone, Nancy D.; Stenson, Mary J.; Novak, Anne; Hedin, Karen E.; Kay, Neil E.; Ansell, Stephen M. // Mayo Clinic Proceedings;Mar2004, Vol. 79 Issue 3, p318 

    • Objective: To assess the clinical relevance of chemokine receptor expression on the progression of B-cell chronic lymphocytic leukemia (B-CLL)., • Patients and Methods: Peripheral blood mononuclear cells from 45 patients with B-CLL were purified and compared with lymph node samples...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics