TITLE

Frequency and factors associated with small intestinal bacterial overgrowth in patients with cirrhosis of the liver and extra hepatic portal venous obstruction

AUTHOR(S)
Lakshmi, C. P.; Ghoshal, Uday C.; Kumar, Sunil; Goel, Amit; Misra, Asha; Mohindra, Samir; Choudhuri, G.
PUB. DATE
April 2010
SOURCE
Digestive Diseases & Sciences;Apr2010, Vol. 55 Issue 4, p1142
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Spontaneous bacterial peritonitis (SBP), a common complication of cirrhosis of liver, might result from translocation of bacteria from the small bowel. However, there is scanty data on frequency of small intestinal bacterial overgrowth (SIBO) in patients with cirrhosis of the liver. There are no data on SIBO in patients with extra-hepatic portal venous obstruction (EHPVO) in the literature. A total of 174 patients with cirrhosis of the liver, 28 with EHPVO and 51 healthy controls were studied for SIBO using glucose hydrogen breath test (GHBT). Persistent rise in breath hydrogen 12 ppm above basal (at least two readings) was considered diagnostic of SIBO. Of 174 patients (age 47.2 +/- 11.9 years, 80.5% male) with cirrhosis due to various causes, 67 (38.5%) were in Child's class A, 70 (40.2%) class B and 37 (21.7%) class C. Of the 174 patients with cirrhosis, 42 (24.14%) had SIBO as compared to 1 of 51 (1.9%) healthy controls (P < 0.0001). Patients with EHPVO had similar frequency of SIBO compared to healthy controls [2/28 (7.14%) vs 1/51 (1.97%), P = ns]. Frequency of SIBO in Child's A, B and C was comparable [13 (18.6%) vs 16 (23.9%) and 13 (35.1%), respectively; P = ns]. Presence of SIBO were not related to ascites, etiology of cirrhosis, and degree of liver dysfunction. SIBO is common in patients with cirrhosis of the liver. Patients with EHPVO do not have higher frequency of SIBO than healthy subjects. SIBO in cirrhosis is not related to the degree of derangement in liver function or of portal hypertension.
ACCESSION #
48600634

 

Related Articles

  • Agenesis of Right Hepatic Lobe Accompanied by Cirrhosis of the Left Hepatic Lobe and Portal Hypertension. Fei Qin; Dong Jiang; Peizhi Li; Lei Zhang; Yi Qin; Yong He; Zuojin Liu // American Surgeon;Dec2012, Vol. 78 Issue 12, pE506 

    The article presents a case study of a 58-year-old woman with a history of liver cirrhosis who presented to the hospital for upper gastrointestinal bleeding. Her family had no history of liver disease and she had no history of alcohol abuse, abdominal surgery, or trauma. The article discusses an...

  • Doppler Assessment of Hepatic Venous Waves for Predicting Large Varices in Cirrhotic Patients. Joseph, Thomas; Madhavan, Mukunda; Devadas, Krishnadas; Ramakrishnannair, Vinayakumar K. // Saudi Journal of Gastroenterology;Jan2011, Vol. 17 Issue 1, p36 

    Background/Aim: Color Doppler examination of changes in hepatic venous waveforms is being evaluated as a means of prediction of severity of portal hypertension and presence of esophageal varices. Normal hepatic venous waveform shows a triphasic pattern. In cirrhosis, this pattern changes to a...

  • Endosonografia w diagnostyce żylaków żoÅ‚Ä…dka. Wiechowska-Kozłowska, Anna; Bialek, Andrzej; Milkiewicz, Piotr // Gastroenterologia Polska / Gastroenterology;2008, Vol. 15 Issue 2, p129 

    Endosonography (EUS), which combines routine endoscopy and ultrasound examination, has been rarely used in the routine diagnostic of portal hypertension. Gastroduodenoscopy is still the method of choice for the diagnosis of varices but it only allows for analysis of superficial varices....

  • Value of Doppler Ultrasound Parameters of Portal Vein and Hepatic Artery in the Diagnosis of Cirrhosis and Portal Hypertension. Iwao, Tadashi; Toyonaga, Msushi; Oho, Kazuhiko; Tanama, Chizuru; Masumoto, Hideo; Sakai, Teruyuki; Sato, Masahiro; Tanikawa, Kyuichi // American Journal of Gastroenterology;Jun1997, Vol. 92 Issue 6, p1012 

    Objectives: This prospective study was designed to assess the sensitivity and specificity of Doppler ultrasound parameters in the diagnosis of cirrhosis and portal hypertension. Methods: Portal and hepatic arterial Doppler ultrasound was performed on 76 patients with cirrhosis and esophageal...

  • Comment on "Hepatic‑associated Immunoglobulin A Nephropathy in a Child with Liver Cirrhosis and Portal Hypertension". Nasri, Hamid; Mubarak, Muhammed // Saudi Journal of Gastroenterology;May/Jun2014, Vol. 20 Issue 3, p202 

    A letter to the editor is presented in response to the article "Hepatic-associated immunoglobulin-A nephropathy in a child with liver cirrhosis and portal hypertension."

  • Liver elastography for the diagnosis of portal hypertension in patients with liver cirrhosis. Şirli, Roxana; Sporea, Ioan; Bota, Simona; Raţiu, Iulia // Medical Ultrasonography;Sep2012, Vol. 14 Issue 3, p225 

    Progressive hepatic fibrosis is a feature of almost all chronic liver diseases. In their final stage, advanced cirrhosis, the clinical signs are diagnostic, but compensated liver cirrhosis is not always easy to diagnose. Apart from liver biopsy, serologic and elastographic non invasive methods...

  • Tc-phytate trans-splenic portal scintigraphy in the diagnosis of cirrhotic portal hypertension and compensatory circulation. Khan, Aakif; Irfanullah, Javaid; Shah, Syed; Fatima, Shazia // Abdominal Imaging;Feb2015, Vol. 40 Issue 2, p258 

    Background and aim: The trans-splenic portal scintigraphy (TPS) was evaluated as a diagnostic tool in the post viral hepatitis cirrhotic patients of various classes of Child Pugh's (CP) classification. The main aim was to determine the portosystemic shunt index (PSSI) and to compare the results...

  • Beta-Blockers in Portal Hypertension. Wilken, Estelle // South African Gastroenterology Review;2015, Vol. 13 Issue 1, p24 

    The article discusses the use of beta-blockers to treat portal hypertension and cirrhosis. The article explains various complications of these diseases which includes the infection of Esophagus which is treated by gastroscopy. These diseases can also cause various gastric disease which leads to...

  • An Endoscopic Injection With N-butyl-2- cyanoacrylate Used for Colonic Variceal Bleeding: A Case Report and Review of the Literature. Wen-Chi Chen; Ming-Chih Hou; Han-Chieh Lin; Full-Young Chang; Shou-Dong Lee // American Journal of Gastroenterology;Feb2000, Vol. 95 Issue 2, p540 

    We report a 64-yr-old patient with liver cirrhosis and bleeding esophageal varices that were obliterated by repeated endoscopic sclerotherapy. Eleven years later, he developed a massive, life-threatening rectosigmoid variceal hemorrhage. An endoscopic injection with N-butyl-2-cyanoacrylate...

  • Idiopathic Portal Hypertension. Boyer, J. L.; Gupta, K. P. Sen; Biswas, S. K.; Pal, N. C.; Mallick, K. C. Basu; Iber, F. L.; Basu, A. K. // Annals of Internal Medicine;Jan67, Vol. 66 Issue 1, p41 

    Presents a study which compared the clinical and pathological features between patients with noncirrhotic portal fibrosis and patients with cirrhosis and extrahepatic obstruction. Information on portal hypertension; Clinical presentation of portal hypertension in India; Symptoms of portal...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics