Efficacy of Gastric Electrical Stimulation in Improving Functional Vomiting in Patients with Normal Gastric Emptying

Reddymasu, Savio C.; Zhiyue Lin; Sarosiek, Irene; Forster, Jameson; McCallum, Richard W.
April 2010
Digestive Diseases & Sciences;Apr2010, Vol. 55 Issue 4, p983
Academic Journal
The objective of this study is to evaluate the utility of gastric electrical stimulation (GES) in the subgroup of patients with refractory nausea and vomiting in the presence of normal gastric emptying. Eighteen patients (15 females) underwent GES implantation for dyspeptic symptoms in the presence of normal gastric emptying. Upper gastrointestinal (UGI) symptom score, health-related quality of life (HR-QOL), nutritional status and weight, and medication use (prokinetics and antiemetics) were assessed at baseline and at 1 year after GES placement. Twelve patients (two males) were included in the final analysis. All patients had normal gastric emptying scintigraphy at baseline. After 1 year of GES, there was a significant reduction in the UGI symptom score from 18 to 10 ( P = 0.001). The physical component score (PCS) of the HR-QOL was also significantly increased from 25 to 42 ( P = 0.04). Gastric emptying actually became slower in 29% of those who repeated the test after 1 year. No adverse events related to GES placement were recorded. Results of our study suggest that GES improves dyspeptic symptoms in patients with medically refractory nausea and vomiting independent of its effect on gastric emptying and could be considered as a potential therapy in this clinical setting.


Related Articles

  • Temporary Endoscopic Stimulation in Gastroparesis-like Syndrome. Singh, Sanjeev; McCrary, Jeff; Kedar, Archana; Weeks, Stephen; Beauerle, Brian; Weeks, Andrew; Endashaw, Omer; Lahr, Chris; Starkebaum, Warren; Abell, Thomas // Journal of Neurogastroenterology & Motility;Oct2015, Vol. 21 Issue 4, p520 

    Background/Aims Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role...

  • Gastric Emptying in Migraine: A Comparison With Functional Dyspepsia. Yeon Hwa Yu; Yunju Jo; Jun Young Jung; Byung Kun Kim; Ju Won Seok // Journal of Neurogastroenterology & Motility;Oct2012, Vol. 18 Issue 4, p412 

    Background/Aims Gastric stasis in migraineurs remains controversial. The aim of this study is to investigate gastric emptying (GE) time, and any associations between GE parameters and dyspeptic symptoms among patients with functional dyspepsia (FD) and migraine without any gastrointestinal...

  • Functional Dyspepsia and Gastroparesis: One Disease or Two? Lacy, Brian E // American Journal of Gastroenterology;Nov2012, Vol. 107 Issue 11, p1615 

    The article focuses on a research paper which aims at classifying the similarities and differences between two gastrointestinal disorders, functional dyspepsia (FD) and gastroparesis (GP). It states that there are several common symptoms of FD and GP which include epigastric pain, nausea, and...

  • The management of diabetic gastroparesis remains less than optimal, despite the use of a multidisciplinary approach.  // Drugs & Therapy Perspectives;May2010, Vol. 26 Issue 5, p12 

    Diabetic gastroparesis frequently occurs in patients with diabetes mellitus. It is characterized by delayed gastric emptying, and associated with symptoms such as postprandial fullness, early satiety, nausea, vomiting and bloating. The causes of diabetic gastroparesis remain unclear. Treatment...

  • Temporary gastric electrical stimulation improves symptoms of nausea and vomiting in patients with both delayed and non-delayed gastric emptying. Batista, Oscar; Ayinala, Srinivasa; Schmieg, Robert; Abell, Thomas L // American Journal of Gastroenterology;Sep2003 Supplement, Vol. 98, pS50 

    An abstract of the article "Temporary Gastric Electrical Stimulation Improves Symptoms of Nausea and Vomiting in Patients With Both Delayed and Non-Delayed Gastric Emptying," by Oscar Bautista and colleagues is presented.

  • A Potential and Novel Therapy for Obesity: 'Appendix' Electrical Stimulation in Dogs. Yong Lei; Chen, Jiande D. Z. // Obesity Surgery;Mar2011, Vol. 21 Issue 3, p397 

    Background: Intestinal electrical stimulation (IES) has been introduced as a potential therapy for obesity. However, it is unknown whether the effects of IES on gastrointestinal motility and food intake are location-specific. The aim of this study was to assess the effects of 'appendix' (cecum...

  • Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice. Ushikai, Miharu; Asakawa, Akihiro; Sakoguchi, Takeo; Tanaka, Chie; Inui, Akio // Endocrine (1355008X);Apr2011, Vol. 39 Issue 2, p113 

    Urocortin 3 (Ucn3) is recognized as a member of the corticotropin-releasing factor (CRF) family, which plays an important role in regulating food intake. We investigated the effects of centrally administered Ucn3 on food intake and gastric emptying in mice. Intracerebroventricular (ICV)...

  • Unusual Case of Gastroparesis Leading to Severe Gastromegaly with Demyelinating Disease as a Rare Cause. Kabir Ahmed; Yasir Lal // South Dakota Medicine;Nov2013, Vol. 66 Issue 11, p467 

    Introduction Gastroparesis is an entity of symptomatic abnormal gastric emptying, with diabetes mellitus, postsurgical and idiopathic etiologies accounting for majority of the cases. Case Report We report the case of a young African American female, who presented with abdominal discomfort,...

  • Idiopathic accelerated gastric emptying presenting in adults with post-prandial diarrhea and reactive hypoglycemia: a case series.  // Journal of Medical Case Reports;2012, Vol. 6 Issue 1, p132 

    The article presents a case study of six patients with gastrointestinal and hypoglycemic symptoms, which were associated with idiopathic accelerated gastric emptying. The symptoms in all cases were removed by taking sweet food or drink, and the response to treatment in all cases was 90 percent...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics