DNMT3B promoter polymorphism and risk of gastric cancer

Jiabo Hu; Hong Fan; Dongsheng Liu; Shuhong Zhang; Feng Zhang; Huaxi Xu; Hu, Jiabo; Fan, Hong; Liu, Dongsheng; Zhang, Shuhong; Zhang, Feng; Xu, Huaxi
April 2010
Digestive Diseases & Sciences;Apr2010, Vol. 55 Issue 4, p1011
Academic Journal
journal article
To investigate the association of single-nucleotide polymorphism (SNP) in DNA methyltransferase 3B (DNMT3B) gene and the risk of gastric cancer (GC), we detected -149C>T and -579G>T in the promoter region of the DNMT3B gene by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing analysis. The DNMT3B genotype was determined in 259 gastric cancer patients and 262 healthy controls that were frequency matched for age and gender. Results showed that individuals with at least one -579G allele were also at significantly decreased risk of gastric cancer [odds ratio (OR), 0.43; 95% confidence interval (CI) 0.26-0.72] compared with those having a -579TT genotype. The -149C>T genotype distribution was irrelevant to the risk of gastric cancer (OR, 1.49; 95% CI, 0.17-17.94) in the studied Chinese population. In addition, data suggested that DNMT3B genetic polymorphism varied among different races, ethnic groups, and geographic areas.


Related Articles

  • Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. Dunstan, Sarah J.; Dougan, Gordon; Ho, Vo An; Duc, Chau Minh; Lanh, Mai Ngoc; Phuong, Cao Xuan Thanh; Luxemburger, Christine; Wain, John; House, Deborah; Dudbridge, Frank; Peacock, Christopher S.; Blackwell, Jenefer M.; Parry, Christopher; Farrar, Jeremy; Hien, Tran Tinh; Dunstan, S J; Ho, V A; Duc, C M; Lanh, M N; Phuong, C X // Journal of Infectious Diseases;4/1/2001, Vol. 183 Issue 7, p1156 

    Control of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance-associated macrophage protein 1 (Nramp1). In this study, we examined the role of genetic polymorphisms in the human homologue,...

  • Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma. Nakahara, Y; Nagai, H; Kinoshita, T; Uchida, T; Hatano, S; Murate, T; Saito, H // Leukemia (08876924);Aug98, Vol. 12 Issue 8, p1277 

    The PTEN/MMAC1 gene at 10q23.3, which has dual specific phosphatase activity, is a novel tumor suppressor gene candidate. Various kinds of tumors have mutations in this gene, including glioblastoma, endometrial carcinoma and prostate cancer. We examined 29 cases of primary non-Hodgkin's lymphoma...

  • CYP17 promoter polymorphism and breast cancer in Australian women under age forty years. Spurdle, Amanda B.; Hopper, John L.; Spurdle, A B; Hopper, J L; Dite, G S; Chen, X; Cui, J; McCredie, M R; Giles, G G; Southey, M C; Venter, D J; Easton, D F; Chenevix-Trench, G // JNCI: Journal of the National Cancer Institute;10/18/2000, Vol. 92 Issue 20, p1674 

    Background: The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5' promoter region of the CYP17 gene. Because steroid hormone exposure is...

  • Mixed Cryptosporidium infections and HIV. Cama, Vitaliano; Gilman, Robert H.; Vivar, Aldo; Ticona, Eduardo; Ortega, Ynes; Bern, Caryn; Lihua Xiao; Xiao, Lihua // Emerging Infectious Diseases;Jun2006, Vol. 12 Issue 6, p1025 

    Mixed Cryptosporidium infections were detected in 7 of 21 patients with a diagnosis of rare Cryptosporidium canis or C. felis infections; 6 patients were infected with 2 Cryptosporidium spp. and 1 patient with 3 species. Mixed infections may occur more frequently than previously believed and...

  • PTPN11 mutations in childhood acute lymphoblastic leukemia occur as a secondary event associated with high hyperdiploidy. Molteni, C. G.; te Kronnie, G.; Bicciato, S.; Villa, T.; Tartaglia, M.; Basso, G.; Biondi, A.; Cazzaniga, G. // Leukemia (08876924);Jan2010, Vol. 24 Issue 1, p232 

    A letter to the editor is presented that discusses PTPN11 mutations in childhood acute lymphoblastic leukemia which is stated to be the event associated with high hyperdiploidy.

  • The polymorphisms of LYRM1 gene and their association with body measurement and ultrasound traits of Qinchuan cattle. Li, Yaokun; Gao, Jianbin; Yang, Ning; Fu, Changzhen; Cheng, Gong; Wang, Hongbao; Zan, Linsen // Molecular Biology Reports;Feb2013, Vol. 40 Issue 2, p1511 

    Body measurement and meat quality traits which play important roles in the assessment of productivity and economy in cattle were influenced by genes and environmental factors. Latest studies showed that LYR motif containing 1 (LYRM1) may be involved in influencing fatness deposition in animals....

  • Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis. Lee, Young; Seo, Young; Kim, Jae-Hoon; Choi, Sung; Ji, Jong; Song, Gwan; Lee, Young Ho; Seo, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu // Neurological Sciences;Nov2015, Vol. 36 Issue 11, p2089 

    We examined whether methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) polymorphisms are associated with susceptibility to multiple sclerosis (MS). We performed a meta-analysis on the association between MS and the following genotypes: MTHFR C677T, A1298C, and GSTP1...

  • Study of regulatory promoter polymorphism (-248 G>A) of Bax gene in patients with gastric cancer in the northern provinces of Iran. Mirmajidi, Seyedeh Habibeh; Najafi, Mojtaba; Mirmajidi, Seyedeh Tahereh; Nasrabadi, Nafiseh Nasri // Gastroenterology & Hepatology from Bed to Bench;Winter2016, Vol. 9 Issue 1, p36 

    Aim: The aim of this study is to evaluate the polymorphism in Bax gene and its association with some clinical pathology traits in gastric cancer. Background: Gastric cancer is considered as the fourth most common cancer in the north and northwest of Iran. Bcl2 family has a key role in regulation...

  • The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. Menard, Laurence; Saadoun, David; Isnardi, Isabelle; Ng, Yen-Shing; Meyers, Greta; Massad, Christopher; Price, Christina; Abraham, Clara; Motaghedi, Roja; Buckner, Jane H.; Gregersen, Peter K.; Meffre, Eric // Journal of Clinical Investigation;Sep2011, Vol. 121 Issue 9, p3635 

    Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The major risk allele encodes an R620W amino acid change that alters B cell receptor (BCR) signaling involved in the regulation of central B cell tolerance. To assess...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics