Environmental exposures and their genetic or environmental contribution to depression and fatigue: a twin study in Sri Lanka

Ball, Harriet A.; Siribaddana, Sisira H.; Sumathipala, Athula; Kovas, Yulia; Glozier, Nick; McGuffin, Peter; Hotopf, Matthew
January 2010
BMC Psychiatry;2010, Vol. 10, Special section p1
Academic Journal
Background: There is very little genetically informative research identifying true environmental risks for psychiatric conditions. These may be best explored in regions with diverse environmental exposures. The current study aimed to explore similarities and differences in such risks contributing to depression and fatigue. Methods: Home interviews assessed depression (lifetime-ever), fatigue and environmental exposures in 4,024 randomly selected twins from a population-based register in the Colombo district of Sri Lanka. Results: Early school leaving and standard of living showed environmentally-mediated effects on depression, in men. In women, life events were associated with depression partly through genetic pathways (however, the temporal order is consistent with life events being an outcome of depression, as well as the other way around). For fatigue, there were environmentally mediated effects (through early school leaving and life events) and strong suggestions of family-environmental influences. Conclusions: Compared to previous studies from higher-income countries, novel environmentally-mediated risk factors for depression and fatigue were identified in Sri Lanka. But as seen elsewhere, the association between life events and depression was partially genetically mediated in women. These results have implications for understanding environmental mechanisms around the world.


Related Articles

  • Why Replication Matters. Sussman, Norman // Primary Psychiatry;Jul2009, Vol. 16 Issue 7, p14 

    An introduction to the journal is presented in which the editor discusses articles on genetic aspects of depression, the role of prefrontal cortex (PFC) in attention and behavior by Amy E. T. Arnsten et al and a case study of a patient who had subconjunctival hemorrhage after receiving escitalopram.

  • A disabling combination: fatigue and depression. Leone, Stephanie S. // British Journal of Psychiatry;Aug2010, Vol. 197 Issue 2, p86 

    Fatigue and common psychiatric symptoms -- depression in particular -- have consistently been found to be strongly associated. All have a negative impact on functional status, but evidence suggests that functional impairment is especially marked when they co-occur. Therefore, it is pertinent to...

  • Genetics of smoking and depression. Tsuang, Ming; Francis, Tracee; Minor, Kyle; Thomas, Alison; Stone, William // Human Genetics;Jun2012, Vol. 131 Issue 6, p905 

    Smoking and depression are significant public health problems with multiple etiological dimensions and outcomes. Although each condition is important by itself, they are important because they often potentiate each other. Consequently, it is also essential to understand the nature their...

  • 5-Hydroxy tryptamine transporter (5HTT) gene promoter region polymorphism in anxiety and depressive disorders. Mushtaq, Raheel; Shoib, Sheikh; Shah, Tabindah; Mushtaq, Sahil // Medical Journal of the Islamic Republic of Iran;2014, Vol. 28, p1 

    Background: 5HTTLPR polymorphism (5-Hydroxy tryptamine transporter linked promoter region polymorphism) is the most widely studied genetic variant in psychiatry. The present study is a modest effort at ascertaining the role of 5HT transporter linked promoter region polymorphism (5HTTLPR) in...

  • KONVERSÄ°YON BOZUKLUÄžU TANISI KONAN ÇOCUK VE ERGENLERÄ°N SOSYODEMOGRAFÄ°K, KLÄ°NÄ°K ÖZELLÄ°KLERÄ° VE EÅž TANILARI. Hesapcioglu, Selma Tural; Aktepe, Evrim; Göker, Zeynep; Kandil, Sema Tanr›över // Yeni Symposium;2010, Vol. 48 Issue 3, p184 

    Objective: The aim of this study is to present the sociodemographic features and comorbid disorFakülteders of children and adolescents with conversion disorder which referred from Trabzon and surrounding cities to Child and Adolescent Psychiatry Department of Karadeniz Technical University...

  • Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Thomson, P. A.; Wray, N. R.; Millar, J. K.; Evans, K. L.; Le Hellard, S.; Condie, A.; Muir, W. J.; Blackwood, D. H. R.; Porteous, D. J. // Molecular Psychiatry;Jul2005, Vol. 10 Issue 7, p657 

    The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis of a large Scottish family in which a t(1;11) translocation cosegregates with schizophrenia, bipolar disorder and recurrent major...

  • The 8th Annual Pharmacogenetics in Psychiatry Meeting Report. Aitchison, K.; Serretti, A.; Goldman, D.; Curran, S.; Drago, A.; Malhotra, A. K. // Pharmacogenomics Journal;Dec2009, Vol. 9 Issue 6, p358 

    The article discusses the highlights of the 8th Annual Pharmacogenetics in Psychiatry Meeting held in New York City. An association study of candidate genes with obesity phenotypes in schizophrenics was presented by Yvon Chagnon. Daniel Mueller of the University of Toronto provided data on the...

  • Gene-environment interaction analysis of serotonin system markers with adolescent depression. Eley, T. C.; Sugden, K.; Corsico, A.; Gregory, A. M.; Sham, P.; McGuffin, P.; Plomin, R.; Craig, I. W. // Molecular Psychiatry;Oct2004, Vol. 9 Issue 10, p908 

    We report analyses from a study of gene-environment interaction in adolescent depression. The sample was selected from 1990 adolescents aged 10–20 years: those with depression symptoms in the top or bottom 15% were identified and divided into high or low environmental risk groups. DNA was...

  • Disruptive insights in psychiatry: transforming a clinical discipline. Insel, Thomas R. // Journal of Clinical Investigation;Apr2009, Vol. 119 Issue 4, p700 

    Mental disorders such as schizophrenia, bipolar illness, and depression have become the predominant chronic diseases of young people, accounting for approximately 40% of the medical burden for people aged 15-44 in the United States and Canada. Research is transforming our understanding of these...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics