TITLE

Effects of Walnut Consumption on Endothelial Function in Type 2 Diabetic Subjects

AUTHOR(S)
Ma, Yingying; Njike, Valentine Yanchou; Millet, John; Dutta, Suparna; Doughty, Kim; Treu, Judith A.; Katz, David L.
PUB. DATE
February 2010
SOURCE
Diabetes Care;Feb2010, Vol. 33 Issue 2, p227
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE -- To determine the effects of daily walnut consumption on endothelial function, cardiovascular biomarkers, and anthropometric measures in type 2 diabetic individuals. RESEARCH DESIGN AND METHODS -- This study was a randomized, controlled, single-blind, crossover trial. Twenty-four participants with type 2 diabetes (mean age 58 years; 14 women and 10 men) were randomly assigned to one of the two possible sequence permutations to receive an ad libitum diet enriched with 56 g (366 kcal) walnuts/day and an ad libitum diet without walnuts for 8 weeks. Subjects underwent endothelial function testing (measured as flow-mediated dilatation [FMD]) and assessment of cardiovascular biomarkers before and after each 8-week treatment phase. The primary outcome measure was the change in FMD after 8 weeks. Secondary outcome measures included changes in plasma lipids, A1C, fasting glucose, insulin sensitivity, and anthropometric measures. RESULTS-- Endothelial function significantly improved after consumption of a walnut-enriched ad libitum diet compared with that after consumption of an ad libitum diet without walnuts (2.2 ± 1.7 vs. 1.2 ± 1.6%; P = 0.04). The walnut-enriched diet increased fasting serum glucose and lowered serum total cholesterol and LDL cholesterol from baseline (10.0 ± 20.5 mg/dl, P = 0.04; -9.7 ± 14.5 mg/dt, P < 0.01; and -7.7 ± 10 mg/dl, P < 0.01, respectively), although these changes were not significant compared with those for an ad libitum diet without walnuts. There were no significant changes in anthropometric measures, plasma A1C, and insulin sensitivity. CONCLUSIONS-- A walnut-enriched ad libitum diet improves endothelium-dependent vasodilatation in type 2 diabetic individuals, suggesting a potential reduction in overall cardiac risk.
ACCESSION #
48477615

 

Related Articles

  • Real-time measurement of thrombin generation using continuous droplet microfluidics. Jiaqing Yu; Ding Tao; Ee Xing Ng; Drum, Chester L.; Ai Qun Liu; Chia-Hung Chen // Biomicrofluidics;2014, Vol. 8 Issue 5, p1 

    Thrombin, which has the leading role in the blood coagulation cascade, is an important biomarker in hemostasis and cardiovascular disease (CVD) development. In this study, a measurement system capable of continuously monitoring individual thrombin generation using droplet microfluidic technology...

  • The effect of dietary saturated fat on endothelial function. Grieger, J. A.; Keogh, J. B.; Noakes, M.; Foster, P. R.; Clifton, P. M. // Asia Pacific Journal of Clinical Nutrition;2004 Supplement, Vol. 13, pS48 

    Background - The impact different dietary fatty acid profiles have on endothelial function is not well understood. Objective - To determine whether diets high in unsaturated fats induce greater endothelial vasodilation compared to diets high in saturated fat (SFA) or carbohydrate (CARB). Design...

  • Association between Human Urotensin II and Essential Hypertension—A 1:1 Matched Case-Control Study. Peng, Hao; Zhang, Mingzhi; Cai, Xiaoqin; Olofindayo, Jennifer; Tan, Anna; Zhang, Yonghong // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    Objective: We aimed to evaluate the controversial association between human urotensin II and essential hypertension in untreated hypertensive cases and normotensive controls. Methods: 197 newly diagnosed hypertensive patients and 197 age- and sex-matched normotensive controls were studied....

  • Thyroid Hormones and Electrocardiographic Parameters: Findings from the Third National Health and Nutrition Examination Survey. Zhang, Yiyi; Post, Wendy S.; Cheng, Alan; Blasco-Colmenares, Elena; Tomaselli, Gordon F.; Guallar, Eliseo // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    Introduction: Altered thyroid status exerts a major effect on the heart. Individuals with hypo- or hyperthyroidism showed various changes in electrocardiograms. However, little is known about how variations in thyroid hormone levels within the normal range affect electrical activities of the...

  • Prolonged AMP-activated protein kinase induction impairs vascular functions. Turkseven, Saadet; Ertuna, Elif // Canadian Journal of Physiology & Pharmacology;Dec2013, Vol. 91 Issue 12, p1025 

    AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism and is involved in the pathogenesis of several diseases, including type 2 diabetes and cardiovascular diseases. Data showing the effects of AMPK on vasculature are controversial. Therefore, the aim of this study was to...

  • Primary Nociceptive Afferents Mediate the Blood Flow Dysfunction in Non-Glabrous (Hairy) Skin of Type 2 Diabetes. Stansberry, Kevin B.; Peppard, Heather R.; Babyak, Lynnette M.; Popp, Gabriele; McNitt, Patricia M.; Vinik, Aaron I. // Diabetes Care;Sep99, Vol. 22 Issue 9, p1549 

    Presents a study which tested the contributions of vascular endothelium, sympathetic activation and inhibition, vessel distensibility, and nociceptor-mediated vasodilation in both glabrous and hairy skin circulations. Research design and methods; Results; Conclusions.

  • Impaired endothelial function in systemic lupus erythematosus. Piper, M. K.; Raza, K.; Nuttall, S. L.; Stevens, R.; Toescu, V.; Heaton, S.; Gardner-Medwin, J.; Hiller, L.; Martin, U.; Townend, J.; Bacon, P. A.; Gordon, C. // Lupus;2007, Vol. 16 Issue 2, p84 

    Systemic lupus erythematosus (SLE) patients suffer from excess cardiac deaths due to accelerated atherosclerosis. Endothelial dysfunction is a marker of early atherosclerosis. We tested the hypothesis that SLE patients have impaired endothelial function and assessed the relationship between...

  • Diet and Lipid Profile of Menopausal Women as Risk Factors of Cardiovascular Disease. Mogra, Renu; Arora, Khushbu // Indian Journal of Public Health Research & Development;Jul-Sep2014, Vol. 5 Issue 3, p104 

    Cardiovascular disease has emerged out as a leading cause of death. Women after menopause are equally at risk of CVDs as men. Risk factors of CVD among the women (45 - 65 years) who have attained menopause were studied. Information on general background, nutritional risk factors like...

  • The Short-Term Effect of Ketogenic Diet on Carotid Intima-Media Thickness and Elastic Properties of the Carotid Artery and the Aorta in Epileptic Children. Doksöz, Önder; Güzel, Orkide; Yılmaz, Ünsal; İşgüder, Rana; Çeleğen, Kübra; Meşe, Timur; Uysal, Utku // Journal of Child Neurology;Oct2015, Vol. 30 Issue 12, p1646 

    The aim of this prospective study is to investigate the effect of a 6-month-long ketogenic diet on carotid intima-media thickness, carotid artery, and aortic vascular functions. Thirty-eight drug-resistant epileptic patients who were being treated with ketogenic diet were enrolled. Fasting total...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics