Accidental induced seizures in three cynomologus macaques following administration of ceftriaxone dissolved in 1% lidocaine diluent

Dror, Moti
January 2010
Laboratory Animals;Jan2010, Vol. 44 Issue 1, p30
Academic Journal
Following initial signs of dural infection, or as prophylactic postoperative therapy, three cynomologus macaques were given an intramuscular or a subcutaneous injection of ceftriaxone dissolved in a 1% lidocaine diluent (CL). Two to 15 min later, all three monkeys experienced a long-lasting generalized apnoeic clonic convulsive seizure. The injected doses of lidocaine (0.7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14.2±3.2 mg/kg) previously reported to induce seizure in healthy rhesus monkeys. Under different clinical conditions, the same three animals were either once (1 animal) or repeatedly given CL without any resultant neurological alterations. The monkeys had a cranial device implanted and two of them were craniotomized. This first report of accidental lidocaine-induced seizure in laboratory non-human primates following CL injection strongly suggests increased susceptibility when lidocaine administration is associated with central nervous system alteration. A novel hypothesis, the possible role of cytokine in lowering the lidocaine seizure threshold, is suggested.


Related Articles

  • Hematopoietic Cytokines - on the Verge of Conquering Neurology. Tonges, Lars; M. Schlachetzki, Johannes C.; Weishaupt, Jochen H.; Bahr, Mathias // Current Molecular Medicine;Mar2007, Vol. 7 Issue 2, p157 

    Two hematopoietic cytokines are currently gaining increasing attention within neurological research. Erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) have long been known for their ability to induce the proliferation of certain populations of hematopoietic lineage cells....

  • The combination of novel targeted molecular agents and radiation in the treatment of pediatric gliomas. Dasgupta, Tina; Haas-Kogan, Daphne A. // Frontiers in Oncology;Apr2013, p1 

    Brain tumors are the most common solid pediatric malignancy. For high-grade, recurrent or refractory pediatric brain tumors, radiation therapy (XRT) is an integral treatment modality. In the era of personalized cancer therapy, molecularly targeted agents have been designed to inhibit pathways...

  • Divergent cerebrospinal fluid cytokine network induced by non-viral and different viral infections on the central nervous system. Souza Bastos, Michele; Coelho-dos-Reis, Jordana Grazziela; Gomes Zauli, Danielle Alves; Gomes Naveca, Felipe; Monte, Rossicleia Lins; Pimentel, João Paulo; Kramer Macário, Valéria Munique; da Silva, Natália Lessa; Peruhype-Magalhães, Vanessa; Pascoal-Xavier, Marcelo Antônio; Guimaraes, Allyson; Teixeira Carvalho, Andréa; Malheiro, Adriana; Martins-Filho, Olindo Assis; Gomes Mourão, Maria Paula // BMC Infectious Diseases;Aug2015, Vol. 15 Issue 1, p1 

    Background: Meningoencephalitis is one of the most common disorders of the central nervous system (CNS) worldwide. Viral meningoencephalitis differs from bacterial meningitis in several aspects. In some developing countries, bacterial meningitis has appropriate clinical management and...

  • Flecainide for the treatment of chronic neuropathic pain: a Phase II trial: Eastern Co-operative Oncology Group Study E1Z95. von Gunten, Charles F.; Eappen, Sarah; Cleary, James Francis; Taylor IV, Samuel G.; Moots, Paul; Regevik, Nina; Cleeland, Charles; Cella, David // Palliative Medicine;Dec2007, Vol. 21 Issue 8, p667 

    Background: Management of neuropathic pain is challenging. Medications that interfere with sodium channel transport, such as lidocaine, mexilitene and flecainide, are promising as analgesics. Objective: In a general population of patients with a working diagnosis of neuropathic pain, whether if...

  • Immunotherapy plus high-dose chemotherapy effective in primary CNS lymphoma. Rubenstein, James L. // Hem/Onc Today;5/25/2013, Vol. 14 Issue 10, p36 

    The article discusses the findings of the Cancer and Leukemia Group B Alliance 50202 clinical trial which demonstrated the feasibility of high-dose chemotherapy consolidation in a multicenter setting in patients with newly diagnosed primary central nervous system lymphoma.

  • Role of Cytokines in Neurological Disorders. Aarli, Johan A. // Current Medicinal Chemistry;Oct2003, Vol. 10 Issue 19, p1931 

    The balance between cytokines with pro- and anti-inflammatory effects contributes to the course of the Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy. TNFa seems to be an important factor in the cascade of events leading to demyelination and even axonal damage....

  • CNS tumours.  // Annals of Oncology;2016 Supplement, Vol. 27, pvi103 

    No abstract available.

  • Some neuroimmunoendocrine aspects in autoimmune diseases. Cojocaru, Manole; Cojocaru, Inimioara Mihaela; Silosi, Isabela // Maedica - a Journal of Clinical Medicine;2008, Vol. 3 Issue 1, p35 

    Considerable evidence now supports the idea of active communication between the nervous and immune systems. The realization that there are interactions between the central nervous system and the immune system arose from clinical observations indicating that mood states may affect susceptibility...

  • Multiple sclerosis: diagnostic optimism. McDonald, W.I. // BMJ: British Medical Journal (International Edition);5/16/92, Vol. 304 Issue 6837, p1259 

    Examines the diagnosis of multiple sclerosis. Characteristics of disease; Impact of cytokines on the inflammatory phase; Effect of multiple sclerosis on the central nervous system.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics