TITLE

Fibrin Sealant: Past, Present, and Future: A Brief Review

AUTHOR(S)
Spotnitz, William D.
PUB. DATE
April 2010
SOURCE
World Journal of Surgery;Apr2010, Vol. 34 Issue 4, p632
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fibrin sealant is a two-component topical hemostat, sealant, and tissue adhesive consisting of fibrinogen and thrombin that has been used in the United States as a blood bank- or laboratory-derived product since the 1980s and has been commercially available since 1998. Initially, surgeons employed hospital-based materials because of the lack of availability of a commercially produced agent. At present, there are five U.S. Food and Drug Administration (FDA)-approved forms including products derived from pooled or autologous human plasma as well as bovine plasma. On-label indications include hemostasis, colonic sealing, and skin graft attachment. Recent clinical and experimental uses include tissue or mesh attachment, fistula closure, lymphatic sealing, adhesion prevention, drug delivery, and tissue engineering. The modern literature on fibrin sealant now exceeds 3000 articles and continues to expand. This brief review presents the history of this material, its present clinical use, and its future applications.
ACCESSION #
48409571

 

Related Articles

  • Raplixaâ„¢: A Review in Improving Surgical Haemostasis. McKeage, Kate // Clinical Drug Investigation;Aug2015, Vol. 35 Issue 8, p519 

    Raplixaâ„¢ is a novel fibrin sealant containing a blend of human fibrinogen and thrombin in powder form. It is approved in adults to help control bleeding when standard surgical techniques have been insufficient. This article summarizes the product characteristics of Raplixa and provides a...

  • Intraluminal Application of Fibrinogen Adhesive by the Example of the Endarterectomised Pig Aorta. Rendl, K. H.; Waldstein, N.; Waclawiczek, H. W. // Vascular Surgery;Nov/Dec1983, Vol. 17 Issue 6, p336 

    The gluing of tissue with highly concentrated fibrinogen, designated in the following briefly as fibrin gluing, is a relatively old technique. Bergel already reported in 1909 on first trials of hemostasis with fibrin powder. In 1915, Grey used a fibrin solution prepared from sheep blood for...

  • FDA OKs fibrin sealant.  // Orthopedics Today;Feb2008, Vol. 28 Issue 2, p84 

    The article reports on the expanded indication granted by the U.S. Food & Drug Administration for the drug Evicel Fibrin Sealant from Ethicon Inc. The product is indicated as an adjunct to hemostasis for use in patients undergoing surgery. The product's features as well as indications are discussed.

  • The Sutureless Microanastomosis. Gestring, Gidon F.; Lerner, R.; Requena, Ramiro // Vascular Surgery;Nov/Dec1983, Vol. 17 Issue 6, p364 

    It has recently become clinically feasible to extract highly concentrated fibrinogen from the patient's own blood. In combination with commercial thrombin this fibrinogen/thrombin compound can be used as tissue adhesive, hemostatic agent and intravascular embolizer. In this presentation the...

  • Fibrin glue. Atrah, H.I. // BMJ: British Medical Journal (International Edition);4/9/94, Vol. 308 Issue 6934, p933 

    Examines the use of fibrin glue injection for hemostasis. Components of fibrin glue; Sources of fibrin glue; Value of fibrin glue for a range of surgical indications.

  • Sealant approved for blood vessel bleeding.  // FDA Consumer;Jul/Aug98, Vol. 32 Issue 4, p7 

    Reports on the approval of a blood-derived sealant called `fibrin,' by the United States Food and Drug Administration on May 1, 1998. Effectiveness of this product in cardiopulmonary bypass, colostomy operations and when the spleen has been injured traumatically; Manufacturer of this sealant.

  • A new fibrin sealant: hemostatics evaluation in the animal model. Hashemi Tayer, A.; Amirizadeh, N.; Almasi-Hashiani, A.; Kamravan, M.; Mohammadi, M. H. // Scientific Journal of Iranian Blood Transfusion Organization;Autumn2013, Vol. 10 Issue 3, p289 

    Background and Objectives Fibrin based sealants are frequently used to arrest blood loss in surgery. The aim of this study was to prepare fibrin-based sealants from thrombin and fibrinogen and evaluate the hemostatic efficacy of the fibrin sealant in a rabbit animal model. Materials and Methods...

  • Impact of fibrin sealant on Limberg flap technique: results of a randomized controlled trial. Altinli, E.; Koksal, N.; Onur, E.; Celik, A.; Sumer, A. // Techniques in Coloproctology;Mar2007, Vol. 11 Issue 1, p22 

    Pilonidal disease is a common chronic disorder mainly seen in the sacrococcygeal region, especially in young males. Different surgical methods have been described for the treatment. Limberg flap has low morbidity and recurrence rates. Fibrin sealant, a two-component tissue adhesive composed of...

  • Endoscopic treatment of anastomotic leakage with fibrin glue. Peker, Kemal; Demiryı, İsmail; ;lmaz; Yılmaz, İsmayil // Dicle Medical Journal / Dicle Tip Dergisi;2013, Vol. 40 Issue 3, p490 

    Surgeons have been using sutures made up of different materials to reunite disrupted tissues, throughout centuries. But these materials may have certain disadvantages like foreign body reaction, infection, scarring, need for removal and cost. Their application is time-consuming and needs skill...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics