Presentation and Survival of Operable Esophageal Cancer in Patients 55 Years of Age and Below

Hamouda, A.; Forshaw, M.; Rohatgi, A.; Mirnezami, R.; Botha, A.; Mason, R.
April 2010
World Journal of Surgery;Apr2010, Vol. 34 Issue 4, p744
Academic Journal
The increased incidence of esophageal cancer, especially in the younger age group, should encourage early diagnosis. The perceived rarity and poor prognostic outcome of esophageal cancer in this group is based on retrospective studies. The goal of this study was to review the presentation and survival of young patients with esophageal cancer. This study was conducted from 2000 to 2007 in a specialized esophagogastric center. All patients who had esophageal cancer operations were included. Variables collected included ages, duration of symptoms, presenting symptoms, tumor characteristics, and follow-up data. In total, 365 esophagectomies were performed for cancer, of which 76 patients were younger than aged 55 years (20.8%) and 289 were older than aged 55 years. In patients younger than aged 55 years, 15 patients had symptoms for 6 months or more, 54 had dysphagia, 35 had weight loss compared with 220 and 175 respectively of patients older than aged 55 years. On histopathology, 48 had T3 tumors (63.2%), 17 had T2 (22.4%), and 10 had T1 (13.2%) for patients younger than aged 55 years compared with 141 had T3 (48.7%), 85 had T2 (29.4%), and 55 had T1 (19%) for patients older than aged 55 years. These differences in tumor stage at presentation between groups were significant ( p < 0.05 with 3DF). In-hospital mortality was 0 for the group younger than aged 55 years and 5 for those older than aged 55 years. Average follow-up was 35 (minimum, 15) months. Thirty patients had locoregional recurrence in the first group and 110 in the latter group. Survival at 1 year after surgery was 79.6%, at 2 years 65.1%, and at 5 years 42.3% compared with 78.4, 60.6, and 45.9%, respectively, for the group older than aged 55 years, but this was not significant using log-rank ( p = 0.99). A significant proportion (20.8%) of patients presenting with operable esophageal cancer was younger than aged 55 years. Almost two-thirds of those presenting younger than aged 55 years had T3 stage tumors, which was significantly different than those older than aged 55 years. Despite more advanced tumor stage at presentation, the prognosis of esophageal cancer for patients younger than aged 55 years is similar to those older than aged 55 years (log-rank = 0.99).


Related Articles

  • Pancreas Cancer, basic and clinical parameters. Ghadimi, B. Michael; Becker, Heinz // Encyclopedic Reference of Cancer;2001, p676 

    A reference entry for cancer of the pancreas is presented. It refers to an epithelial malignancy of the pancreatic gland that originates in more than 85% of the cases from ductal cells. Several unspecific symptoms are associated with pancreatic cancer such as fatigue, weight loss, jaundice and...

  • Investigation of Resected Multinodular Hepatocellular Carcinoma: Assessment of Unicentric or Multicentric Genesis from Histological and Prognostic Viewpoint. Nakano, Shu; Haratake, Joji; Okamoto, Kohji; Takeda, Shigeaki // American Journal of Gastroenterology;Feb1994, Vol. 89 Issue 2, p189 

    Objectives: Multicentricity of hepatocellular carcinoma (HCC) is attracting a great deal of attention at present. However, few studies have focused on the prognostic comparison between unicentric and multicentric multinodular HCCs. The aim of this study is the reevaluation of histologic criteria...

  • Giant cell carcinoma of endometrium: A rare case report and review of literature. Sharma, Preeti; Ahluwalia, Charanjeet; Kolte, Sachin; Kumar Mandal, Ashish // Clinical Cancer Investigation Journal;Jan/Feb2016, Vol. 5 Issue 1, p79 

    Giant cell carcinoma of uterus is an aggressive form of endometrial carcinoma. It can be confused on histopathology with other giant cell containing lesions including trophoblastic tumors, certain primary sarcomas, and malignant mixed müllerian tumors. Due to the paucity of cases of this rare...

  • Granular Cell Tumors on Unusual Anatomic Locations. Hee Joo Kim; Min-Geol Lee // Yonsei Medical Journal;Nov2015, Vol. 56 Issue 6, p1731 

    Granular cell tumors (GCTs) are soft tissue tumors, which are thought to be derived from Schwann cells. Although most GCTs are reported to arise in tongue and oral cavity (30-50%), they can appear on any anatomic sites, even visceral organs. Herein, we report 5 cases of GCTs on unusual anatomic...

  • Adrenal Incidentaloma: A Rare Presentation and Anaesthetic Implications. Thakur, Preeti; Sitalakshmi, N. // New Indian Journal of Surgery;Jul-Sep2015, Vol. 6 Issue 3, p87 

    Pheochromocytomas are rare tumors which most commonly present with paroxysmal hypertension, headache, diaphoresis and palpitation. Very rarely, they are diagnosed incidentally on abdominal ultrasound or CT scan done for some other purpose, following which rose urinary and plasma levels of...

  • What Levels of Agreement Can Be Expected Between Histopathologists Assigning Cases to Discrete Nominal Categories? A Study of the Diagnosis of Hyperplastic and Adenomatous Colorectal Polyps. Cross, Simon S.; Betmouni, Samar; Burton, Julian L.; Dubé, Asha K.; Feeley, Kenneth M.; Holbrook, Miles R.; Landers, Robert J.; Lumb, Phillip B.; Stephenson, Timothy J. // Modern Pathology;Sep2000, Vol. 13 Issue 9, p941 

    Aims: To assess the levels of agreement between histopathologists for a two-class nominal categorization process-the discrimination between hyperplastic and adenomatous colorectal polyps. Methods: Fifty hyperplastic and 50 adenomatous polyps received consecutively in the laboratory were...

  • Histologic criteria for diagnosing primary cutaneous malignant melanoma. Smoller, Bruce R. // Modern Pathology;Feb2006 Supplement 2, Vol. 19, p34 

    Malignant melanoma accounts for the largest number of deaths attributed to skin cancer. It also provides the most diagnostic challenges for the histopathologist. This article, attempts to describe the histologic features most closely associated with the various growth patterns of the most common...

  • The expression pattern of 19 genes predicts the histology of endometrial carcinoma. Chang Ohk Sung; Insuk Sohn // Scientific Reports;6/6/2014, p1 

    Cancer diagnosis and classification have traditionally been based on the assessment of morphology by microscopy. However, the histological classification system is challenging and demand for genetic information is increasing in the era of targeted and personalized molecular therapy. Recently...

  • Patillary Poroid Hidradenoma: A Distinct Histopathological Entity A Rare Case Report. DRAVID, N. V.; GADRE, A. S.; DAMLE, R. P.; BAGALE, P. S.; SURYAWANSHI, K. H. // Journal of Clinical & Diagnostic Research;Mar2014, Vol. 8 Issue 3, p138 

    Papillary poroid hidradenoma is a very rare entity which belongs to poroid neoplasms, which represents 10% of sudoriferous tumours. It can be easily misdiagnosed as a malignant neoplasm. A 34-years-old male presented with an asymptomatic mass over the right chest wall, below the nipple, of 18...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics