Effect of Transoral Incisionless Fundoplication on Symptoms, PPI Use, and pH-Impedance Refluxes of GERD Patients

Testoni, Pier Alberto; Corsetti, Maura; Di Pietro, Salvatore; Castellaneta, Antonio Gianluca; Vailati, Cristian; Masci, Enzo; Passaretti, Sandro
April 2010
World Journal of Surgery;Apr2010, Vol. 34 Issue 4, p750
Academic Journal
Three previous studies from the same institution have reported that transoral incisionless fundoplication (TIF) with the EsophyX device is effective for creating a continent gastroesophageal valve and for good functional results as measured only by pH-metry in patients with gastroesophageal reflux disease (GERD). The objective of the present study was to evaluate the effect of TIF on symptoms, use of proton pump inhibitors (PPI), esophageal motility, and pH-impedance in patients with symptomatic GERD. Twenty consecutive patients were enrolled to complete the GERD-HRQL and GERD-QUAL questionnaires while on and off PPI. They were also examined by upper gastrointestinal (GI) endoscopy to determine Hill grade and Jobe length of the gastroesophageal valve, and to check for hiatal hernia and esophagitis, esophageal manometry, and pH-impedance before and 6 months after TIF. Six months after TIF, the GERD-HRLQ and GERD-QUAL scores off-PPI therapy and the number of total and acid pH-impedance refluxes were significantly reduced ( p < 0.05). The PPI had been completely stopped in 55% of the patient and was reduced in 22% of the patients. At 6-month follow-up, TIF performed using the EsophyX device reduces symptoms and pH-impedance refluxes, allowing interruption or reduction of PPI use in 78% of patients with GERD.


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