TITLE

Longitudinal Profiles of 15 Serum Bile Acids in Patients With Intrahepatic Cholestasis of Pregnancy

AUTHOR(S)
Tribe, Rachel M.; Dann, Anthony T.; Kenyon, Anna P.; Seed, Paul; Shennan, Andrew H.; Mallet, Anthony
PUB. DATE
March 2010
SOURCE
American Journal of Gastroenterology;Mar2010, Vol. 105 Issue 3, p585
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES:Increased maternal serum bile acids are implicated in intrahepatic cholestasis of pregnancy. Individual bile acid profiles and their relationship with disease progression, however, remain unknown. The purpose of this prospective study was to determine the temporal changes in bile acids in normal pregnancy and in pregnancies complicated with intrahepatic cholestasis of pregnancy and pruritus gravidarum.METHODS:A validated method for the evaluation of 15 bile acids (conjugated and unconjugated) in a single serum sample was developed using high-performance liquid chromatography/mass spectrometry (HPLC-MS) with an electrospray interface. Bile acid concentrations were assessed in samples (16 weeks of gestation to 4 weeks postpartum) from women with, or who later developed, intrahepatic cholestasis of pregnancy (n=63) and were compared with those from normal pregnant women (n=26) and from women with pruritus gravidarum (n=43).RESULTS:Intrahepatic cholestasis of pregnancy was associated with a predominant increase in cholic acid conjugated with taurine and glycine, from 24 weeks of pregnancy. Ursodeoxycholic acid (UDCA) treatment (≥21 days, n=15) significantly reduced serum taurocholic and taurodeoxycholic acid concentrations (P<0.01). Bile acid profiles were similar in normal pregnancy and pregnancy associated with pruritus gravidarum.CONCLUSIONS:The bile acid profiles and effects of treatment by UDCA implicate a role for taurine-conjugated bile acids in the syndrome of intracranial pressure. With regard to individual bile acid profiles, pruritus gravidarum is a disorder quite distinct from intrahepatic cholestasis of pregnancy.
ACCESSION #
48400334

 

Related Articles

  • Editorial: Bile Acid Profiles in Intrahepatic Cholestasis of Pregnancy: Is This the Solution to the Enigma of Intrahepatic Cholestasis of Pregnancy? Sinakos, Emmanouil; Lindor, Keith D. // American Journal of Gastroenterology;Mar2010, Vol. 105 Issue 3, p596 

    Intrahepatic cholestasis of pregnancy (ICP) is a rare pregnancy-related liver disease characterized by pruritus, abnormal liver function tests, and an increased risk of fetal complications. An increase in the levels of bile acids is considered to be the diagnostic hallmark of the disease....

  • Intrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid. Joutsiniemi, Titta; Timonen, Susanna; Linden, Maria; Suvitie, Pia; Ekblad, Ulla // BMC Gastroenterology;Jul2015, Vol. 15 Issue 1, p1 

    Background: To exam the biochemical, obstetric management and pregnancy outcome in women with intrahepatic cholestasis of pregnancy (ICP) and treatment with ursodeoxycholic acid (UDCA). Methods: Pregnancy outcome in patients with ICP (N = 307) was studied and patients treated with UDCA (N = 208)...

  • Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial. ZHANG, L.; LIU, X.-H.; QI, H.-B.; LI, Z.; FU, X.-D.; CHEN, L.; SHAO, Y. // European Review for Medical & Pharmacological Sciences;2015, Vol. 19 Issue 19, p3770 

    OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is a special complication of pregnancy characterized by skin pruritus, abnormal liver function tests and bile acids. To compare the efficacy of ursodeoxycholic acid (UDCA) and S-adenosylmethionine (SAMe) monotherapy with their combined...

  • Pilot study for a trial of ursodeoxycholic acid and/or early delivery for obstetric cholestasis. Gurung, Vinita; Williamson, Catherine; Chappell, Lucy; Chambers, Jenny; Briley, Annette; Pipkin, Fiona Broughton; Thornton, Jim // BMC Pregnancy & Childbirth;2009, Vol. 9, Special section p1 

    Background: Obstetric cholestasis (OC) is a serious problem in pregnancy. It affects about 4500 women per year in the UK. Affected women develop itching and occasionally jaundice. More importantly, the condition is associated with premature delivery, fetal distress and is believed to be an...

  • Pregnancy in primary sclerosing cholangitis. Gossard, Andrea; Lindor, Keith // Gut;Aug2011, Vol. 60 Issue 8, p1027 

    In this article the author discusses aspects of the effect of primary sclerosing cholangitis (PSC) in pregnancy. They cite studies which claim that fertility is not affected by the diagnosis of PSC. They discuss suspected intrahepatic cholestasis of preganancy (ICP) in two patients based on...

  • Ursodeoxycholic Acids: A Safe and Effective Agent for Dissolving Cholesterol Gallstones. Tint, G. Stephen; Salen, Gerald; Colalillo, Anthony; Graber, David; Verga, Diane; Speck, Jeffrey // Annals of Internal Medicine;Sep82, Vol. 97 Issue 3, p351 

    Presents a study which examined the effectiveness of using ursodeoxycholic acid in dissolving cholesterol gallstones and their effect on hepatic bile acid metabolism and liver function. Methods used in the study; Results.

  • Analysis of serum bile acids by isotope dilution-mass spectrometry to assess the performance of routine total bile acid methods. Ducroq, D. H.; Morton, M. S.; Shadi, N.; Fraser, H. L.; Strevens, C.; Morris, J.; Thomas, M. A. // Annals of Clinical Biochemistry;Nov2010, Vol. 47 Issue 6, p535 

    Background: WEQAS, one of the largest EQA (External Quality Assessment) providers in the UK, offers a bile acid EQA scheme, with linear serum pools containing cholic acid, deoxycholic acid and chenodeoxycholic acid, reflecting levels observed in obstructive cholestasis. Total bile acids are...

  • Colestasis intrahepática del embarazo: reporte de un caso y revisión de la bibliografía. González-Blanco, Rafael; Sofía Mortara-Gómez, Águeda; Martínez-Uribe, Alfonso; Arias-Loza, Rosa; Sanginés-Martínez, Augusto // Ginecologia y Obstetricia de Mexico;nov2013, Vol. 81 Issue 11, p652 

    Intrahepatic cholestasis of pregnancy has a prevalence of 1/1000 to 1/10000. Its etiology is multifactorial, involving genetic an hormonal factors, associated with adverse perinatal and obstetric outcomes. Report the case of patient 25 years old, with 32 weeks of gestation, which presents severe...

  • Combined endoscopic and ursodeoxycholic acid treatment of biliary cast syndrome in a non-transplant patient. Katsinelos, Panagiotis; Kountouras, Jannis; Chatzimavroudis, Grigoris; Zavos, Christos; Pilpilidis, Ioannis; Paroutoglou, George; Llado, Laura // World Journal of Gastroenterology;9/7/2008, Vol. 14 Issue 33, p5223 

    A 76-year-old diabetic man underwent cholecystectomy for gangrenous calculous cholecystitis. His postoperative course was complicated by the development of Candida albicans esophagitis necessitating antifungal therapy, and total parenteral nutrition (TPN) for 15 d. Seven weeks after...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics