TITLE

Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment

PUB. DATE
December 2009
SOURCE
International Journal of Advances in Rheumatology;2009, Vol. 7 Issue 4, p130
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Methotrexate polyglutamates are believed to represent the active form of the drug, and correlate with clinical response. This group studied 192 rheumatoid arthritis patients on chronic methotrexate therapy and observed that polyglutamate levels increased with age, methotrexate dose, and decreased renal function, but were reduced in smokers.
ACCESSION #
48381928

 

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