Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis

December 2009
International Journal of Advances in Rheumatology;2009, Vol. 7 Issue 4, p124
Academic Journal
The presence of autoantibodies is a key feature in the clinical evaluation of rheumatoid arthritis (RA) patients. In addition to the long-established rheumatoid factor (RF), there are now three tests for anti-citrullinated protein autoantibodies (ACPAs): the second-generation anti-cyclic citrullinated peptide (anti-CCP-2), the third-generation anti-CCP (anti-CCP-3), and the anti-modified citrullinated vimentin autoantibody tests. In this detailed analysis of patients in a clinical practice setting, a single autoantibody test was found to be sufficient for risk estimation in early undifferentiated arthritis with respect to the risk of developing RA, for predicting joint damage in RA, and the risk of having persistent disease.


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