JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice

December 2009
International Journal of Advances in Rheumatology;2009, Vol. 7 Issue 4, p123
Academic Journal
R348, a small molecule inhibitor of the Janus tyrosine kinase 1/3 (JAK1/3) pathway dose-dependently reversed the clinical and histological manifestations of established psoriasiform skin disease in CD18-deficient PL/J mice.


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