TITLE

Cutting edge: regulatory T cells directly suppress B cells in systemic lupus erythematosus

PUB. DATE
December 2009
SOURCE
International Journal of Advances in Rheumatology;2009, Vol. 7 Issue 4, p122
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The abnormal production of autoantibodies is responsible for the pathology in systemic lupus erythematosus (SLE). It is known that regulatory T cells (Tregs ) can inhibit antibody production by suppression of T helper cells. In this study, it was demonstrated that natural Tregs inhibit B cell activity in vitro and in vivo in SLE through cell contact-mediated mechanisms that directly suppress autoantibody-producing B cells.
ACCESSION #
48381913

 

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