March 2010
Worldwide Biotech;Mar2010, Vol. 22 Issue 3, p8
Trade Publication
The article reports on the discovery and experimental validation of CGEN-15001 for the treatment of autoimmune disorders. It is the extracellular region of a membrane protein in the B7/CD28 family. The parent protein from which CGEN-15001 has been derived was predicted in silico using Compugen's LEADS Platform and other proprietary algorithms.


Related Articles

  • Compugen Announces Initial Validation of Additional B7/CD28 Protein Family Based Product Candidate.  // Biomedical Market Newsletter;6/30/2011, p618 

    The article reports on the initial validation of additional B7/CD28 protein family product based candidate from Compugen Ltd. It states that B7/CD28 protein family have significant therapeutic potential in multiple areas of medicine including autoimmune diseases, transplantation and cancer. It...

  • Effect of Ion Concentration Changes in the Limited Extracellular Spaces on Sarcolemmal Ion Transport and Ca2+ Turnover in a Model of Human Ventricular Cardiomyocyte. Hrabcová, Dana; Pásek, Michal; Šimurda, Jiří; Christé, Georges // International Journal of Molecular Sciences;Dec2013, Vol. 14 Issue 12, following p24271 

    We have developed a computer model of human cardiac ventricular myocyte (CVM), including t-tubular and cleft spaces with the aim of evaluating the impact of accumulation-depletion of ions in restricted extracellular spaces on transmembrane ion transport and ionic homeostasis in human CVM. The...

  • Screening for Voltage-Gated Sodium Channel Interacting Peptides. Er Meng; Tian-Fu Cai; Hui Zhang; Si Tang; Meng-Jie Li; Wen-Ying Li; Peng-Fei Huang; Kai Liu; Lei Wu; Ling-Yun Zhu; Long Liu; Kuan Peng; Xian-Dong Dai; Hui Jiang; Xiong-Zhi Zeng; Song-Ping Liang; Dong-Yi Zhang // Scientific Reports;4/4/2014, p1 

    The voltage-gated sodium channel (VGSC) interacting peptide is of special interest for both basic research and pharmaceutical purposes. In this study, we established a yeast-two-hybrid based strategy to detect the interaction(s) between neurotoxic peptide and the extracellular region of VGSC....

  • Israeli Genomics Company Spin-Off to Focus on Small-Molecule Drugs. Terry, Mark // Drug Discovery & Development;Sep2004, Vol. 7 Issue 9, p20 

    The article reports on the announcement made by pharmaceutical company Compugen Ltd., to spun off its chemistry division into a subsidiary, Keddem Bioscience Ltd. Both Compugen and Keddem aim to increase the probability of success of drug discovery by incorporating ideas and methods from...

  • Linking agonist binding to histamine H1 receptor activation. Jongejan, Aldo; Bruysters, Martijn; Ballesteros, Juan A.; Haaksma, Eric; Bakker, Remko A.; Pardo, Leonardo; Leurs, Rob // Nature Chemical Biology;Jul2005, Vol. 1 Issue 2, p98 

    G protein–coupled receptors (GPCRs) constitute a large and functionally diverse family of transmembrane proteins. They are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways and are among the most targeted proteins in drug discovery. The detailed...

  • Evidence for a protein tether involved in somatic touch. Jing Hu; Li-Yang Chiang; Koch, Manuel; Lewin, Gary R. // EMBO Journal;2/17/2010, Vol. 29 Issue 4, p855 

    The gating of ion channels by mechanical force underlies the sense of touch and pain. The mode of gating of mechanosensitive ion channels in vertebrate touch receptors is unknown. Here we show that the presence of a protein link is necessary for the gating of mechanosensitive currents in all...

  • Tau Overexpression Results in Its Secretion via Membrane Vesicles. Simón, Diana; García-García, Esther; Gómez-Ramos, Alberto; Falcón-Pérez, Juan Manuel; Díaz-Hernández, Miguel; Hernández, Félix; Avila, Jesús // Neurodegenerative Diseases;Apr2012, Vol. 10 Issue 1-4, p73 

    Background: Tau protein, the main component of neurofibrillary tangles, could be found in the extracellular space upon neuronal death or, as it has recently been suggested, could be secreted from cells through membrane vesicles. Objective: The purpose of this communication is to confirm that...

  • Constitutive Cleavage of the Single-Pass Transmembrane Protein Alcadeina Prevents Aberrant Peripheral Retention of Kinesin-1. Maruta, Chiaki; Saito, Yuhki; Hata, Saori; Gotoh, Naoya; Suzuki, Toshiharu; Yamamoto, Tohru; Iijima, Koichi M. // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Various membrane proteins are shed by proteinases, constitutively and/or when stimulated by external signals. While the physiological significance of external signal-induced cleavages has been intensely investigated, relatively little is known about the function of constitutive cleavages....

  • Deficiency of Angulin-2/ILDR1, a Tricellular Tight Junction-Associated Membrane Protein, Causes Deafness with Cochlear Hair Cell Degeneration in Mice. Higashi, Tomohito; Katsuno, Tatsuya; Kitajiri, Shin-ichiro; Furuse, Mikio // PLoS ONE;Mar2015, Vol. 10 Issue 3, p1 

    Tricellular tight junctions seal the extracellular spaces of tricellular contacts, where the vertices of three epithelial cells meet, and are required for the establishment of a strong barrier function of the epithelial cellular sheet. Angulins and tricellulin are known as specific protein...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics