TITLE

Organelle-specific, rapid induction of molecular activities and membrane tethering

AUTHOR(S)
Komatsu, Toru; Kukelyansky, Igor; McCaffery, J. Michael; Ueno, Tasuku; Varela, Lidenys C.; Inoue, Takanari
PUB. DATE
March 2010
SOURCE
Nature Methods;Mar2010, Vol. 7 Issue 3, p206
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Using new chemically inducible dimerization probes, we generated a system to rapidly target proteins to individual intracellular organelles. Using this system, we activated Ras GTPase at distinct intracellular locations and induced tethering of membranes from two organelles, endoplasmic reticulum and mitochondria. Innovative techniques to rapidly perturb molecular activities and organelle-organelle communications at precise locations and timing will provide powerful strategies to dissect spatiotemporally complex biological processes.
ACCESSION #
48330495

 

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