Role of Antiepileptic Drugs as Preventive Agents for Migraine

Vikelis, Michail; Rapoport, Alan M.
January 2010
CNS Drugs;2010, Vol. 24 Issue 1, p21
Academic Journal
Migraine is a common neurological disease affecting about 12% of the population in Western Europe and North America, and causing a considerable burden both to migraineurs and to society. Severe, frequent and disabling migraine attacks, as well as those poorly responsive to acute care medication, require preventive treatment, which is often under-utilized. Antiepileptic drugs are used in the prevention of migraine. We performed a literature search of PubMed through June 2008 for controlled trials of antiepileptic drugs in the prevention of migraine. The search identified 70 papers for a full-text review. The majority of these papers referred to valproate and topiramate, and showed that these drugs are effective and well tolerated in migraine prevention and are suitable for first-line clinical use. On the other hand, acetazolamide, lamotrigine, oxcarbazepine and vigabatrin have been shown to be not effective and gabapentin requires further evaluation. For the rest of the antiepileptic drugs, no data from controlled trials are available.


Related Articles

  • Efficacy of a combination of sodium valproate and baclofen in Meige's disease diopathic orofacial dystonia). Brennan, M.J.W.; Ruff, P.; Sandyk, R. // British Medical Journal (Clinical Research Edition);9/25/1982, Vol. 285 Issue 6345, p853 

    Examines the effectiveness of sodium valproate and baclofen in treating patients with Meige's disease. Characteristics of Meige's disease; Impact of stress on dystonic movements; Effects of sodium valproate on gamma aminobutyric acid synaptic concentration.

  • Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability. Li, Xingbao; Ricci, Raffaella; Large, Charles H.; Anderson, Berry; Nahas, Ziad; George, Mark S. // Journal of Neural Transmission;Apr2009, Vol. 116 Issue 4, p423 

    To investigate different cortical effects of lamotrigine and valproic acid, 30 paid healthy adult men were given, in a randomized/blinded fashion on three separate days (separated by a week), either a single dose of lamotrigine 325 mg, or a single dose of valproic acid 1,250 mg, or placebo....

  • Treating Rapid Cycling Bipolar Disorder with Novel Medications. Erkan Ozcan, Mehmet; Shivakumar, Geetha; Suppes, Trisha // Current Psychiatry Reviews;2006, Vol. 2 Issue 3, p361 

    Background: Brief definition of rapid cycling is the occurrence of at least four mood episodes in a year. It may be seen in patients with bipolar I, or bipolar II disorder. Rapid cycling bipolar disorder is frequently treatment-resistant. There is need for new, effective medications for the...

  • Lamotrigine, vaiproate emerge as superior epilepsy treatment options as assessed in SANAD trial.  // Formulary;Aug2007, Vol. 42 Issue 8, p494 

    The article focuses on the efficacy of lamotrigine and valproate in treating patients with superior epilepsy. The Standard and New Antiepileptic Drugs (SANAD) trial reveals that lamotrigine demonstrated superior efficacy in patients with partial seizures. It concludes that patients with...

  • Medicines Safety Update.  // Australian Prescriber;Dec2010, Vol. 33 Issue 6, p182 

    The article provides information on the skin reactions caused by lamotrigine. It claims that serious formation of rashes like the Stevens-Johnson syndrome and toxic epidermal necrolysis are likely to develop after the lamotrigine administration. It is therefore recommended to have the...

  • Consider This Option For Your Migraine Patient. Scholz, Mary // RN;Apr2004, Vol. 67 Issue 4, p79 

    Presents a question and answer advisory concerning valproate sodium intravenous, a therapy for severe migraine with no side effects. Efficacy of valproate sodium intravenous; Dose required; Relief action.

  • Recent Advances in the Pharmacotherapy of Infantile Spasms. Riikonen, Raili // CNS Drugs;Apr2014, Vol. 28 Issue 4, p279 

    Adrenocorticotrophic hormone (ACTH), oral corticosteroids and vigabatrin are now first-line treatments for infantile spasms in the US and Europe. There is now increased knowledge regarding the role of ACTH, corticosteroids and vigabatrin (e.g. efficacy, doses, side effects, treatment in specific...

  • The Alice in Wonderland Syndrome: A Case of Aura Accompanying Cluster Headache. Uca, Ali Ulvi; Kozak, Hasan Hüseyin // Balkan Medical Journal;2015, Vol. 32 Issue 3, p320 

    Background: Cluster headache (CH) is a primary headache which has highly specific and sensitive criteria, and notpresence of an aura. It has been recently reported that CH may not presence with aura more than ever and this condition will be identified by headache specialists as a new form of CH....

  • aura. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p79 

    An encyclopedia entry for "aura" is presented. It refers to the sensation that warns the individual about an incoming migraine attack or a seizure in epilepsy. Some of the warning sensations that take place before a migraine attack include a feeling of elation, excessive energy, drowsiness and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics