Differential expression of the actin-binding proteins, α -actinin-2 and -3, in different species: implications for the evolution of functional redundancy

Mills, Michelle; Yang, Nan; Weinberger, Ron; Vander Woude, Douglas L.; Beggs, Alan H.; Easteal, Simon; North, Kathryn
June 2001
Human Molecular Genetics;6/15/2001, Vol. 10 Issue 13
Academic Journal
Presents data concerning the differential expression of alpha-actinin-2 (ACTN2) and alpha-actinin-3 (ACTN3) genes in different species. Evolutionary conservation of the ACTN3 gene; Indication of constraint on evolutionary rate imposed by continued function of the gene; Need for caution in making conclusions about gene function from the phenotypic consequences of loss-of-function mutations in animal knockout models.


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