Johansen, Christopher T.; Gallinger, Zane R.; Jian Wang; Ban, Matthew R.; Kue Young, T.; Bjerregaard, Peter; Hegele, Robert A.
February 2010
International Journal of Circumpolar Health;2010, Vol. 69 Issue 1, p3
Academic Journal
Objectives. To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design. Candidate gene association study of discrete and quantitative traits related to cardiovascular health. Methods. ATGL was sequenced in 10 European subjects to identify DNA sequence variants. The identified polymorphisms were subsequently genotyped in a population-based cohort of 1,218 unrelated Greenland Inuit subjects, ascertained from the Greenland Population Study. Genotypes and reconstructed haplotypes were tested for association with cardiovascular disease risk factors using additive, dominant or recessive models, corrected for age, sex and body mass index. Results. Five single nucleotide polymorphisms and one 4-base pair deletion were identified in the European sample and were similarly polymorphic in the Greenland Inuit. Independently, variants were not associated with any cardiovascular traits. However, reconstructed rare ATGL haplotypes were associated with increased plasma triglyceride (TG) concentrations compared to the major haplotype under a dominant model (1.21 ±0.7 mmol/L and 1.11 ± 0.6 mmol/L, respectively, p=0.006). Conclusions. Rare ATGL haplotypes are associated with increased plasma TG concentrations in the Greenland Inuit.


Related Articles

  • Effects of RS9939609 Gene Variant in FTO Gene on Weight Loss and Cardiovascular Risk Factors After Biliopancreatic Diversion Surgery. Luis, Daniel; Aller, Rocío; Conde, Rosa; Izaola, Olatz; Pacheco, David; Sagrado, Manuel; Primo, David // Journal of Gastrointestinal Surgery;Jun2012, Vol. 16 Issue 6, p1194 

    Background: The high variation in responses to bariatric surgery might be partially explained by genetic effects. Recently, common polymorphisms of the fat mass and obesity-associated gene ( FTO) have been linked to obesity in some populations. Only two studies have investigated the effect of...

  • Association of CVD Candidate Gene Polymorphisms with Ischemic Stroke and Cerebral Hemorrhage in Chinese Individuals. Ou, Wenjing; Liu, Xin; Shen, Yue; Li, Jiana; He, Lingbin; Yuan, Yuan; Tan, Xuerui; Liu, Lisheng; Zhao, Jingbo; Wang, Xingyu // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Background: Contribution of cardiovascular disease related genetic risk factors for stroke are not clearly defined. We performed a genetic association study to assess the association of 56 previously characterized gene variants in 34 candidate genes from cardiovascular disease related biological...

  • Predictors of systolic blood pressure in post-menopausal euthyroid women: A study of the NHANES continuous survey data 2007–2012. Khitan, Zeid; Dial, Larry; Santhanam, Prasanna // Post Reproductive Health;Jun2015, Vol. 21 Issue 2, p75 

    There is an increased risk of cardiovascular disease and higher rate of hypertension in post-menopausal (compared to pre-menopausal women). We analysed the cross-sectional National Health and Nutritional Examination and Survey 2007–2012 to look at the factors that affect systolic blood...

  • Perfil lipídico y su relación con el índice de masa corporal en adolescentes de la Unidad Educativa Particular "Universitaria de Azogues", Ecuador. Álvarez Ochoa, Robert Iván; Conchado Martínez, Julio Héctor; Garcés Ortega, Juan Pablo; Cordero Cordero, Gabriela; Saquicela Espinoza, Luis Alberto; Chuquiralagua Ruiz, Paul Emanuel; Yumisaca Tiuquinga, Silvia Verónica; González Ortiz, Diana Patricia; Torres Pérez, Angélica; Rodríguez Torres, Diego Andrés // Revista Latinoamericana de Hipertension;2019, Vol. 14 Issue 2, p213 

    Introduction: Dyslipidemia and excess weight in adolescents are risk factors for the development of cardiovascular diseases both in this period and in adulthood. Materials and methods: a cross-sectional descriptive study was carried out that included 74 third and fourth year students of the...

  • Low-Density Lipoprotein Electronegativity Is a Novel Cardiometabolic Risk Factor. Hsu, Jing-Fang; Chou, Tzu-Chieh; Lu, Jonathan; Chen, Shu-Hua; Chen, Fang-Yu; Chen, Ching-Chu; Chen, Jeffrey L.; Elayda, MacArthur; Ballantyne, Christie M.; Shayani, Steven; Chen, Chu-Huang // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Background: Low-density lipoprotein (LDL) plays a central role in cardiovascular disease (CVD) development. In LDL chromatographically resolved according to charge, the most electronegative subfraction–L5–is the only subfraction that induces atherogenic responses in cultured...

  • Correlation between mean platelet volume and total risk of cardiovascular disease. MARKOVIĆ, DOMAGOJ; CAREVIĆ, VEDRAN; BONACIN, DAMIR; SEKULIĆ, BRANKA PAUKOVIĆ; SAPUNAR, ADA; FABIJANIĆ, DAMIR // Signa Vitae;Oct2013, Vol. 8 Issue 2, p49 

    Introduction. The association between mean platelet volume (MPV) and single cardiovascular disease (CVD) risk factors has previously been tested. The aim of our study was to evaluate the association between MPV and total risk of CVD. Materials and Methods. In 216 consecutive outpatients referred...

  • Modifiable cardiovascular risk factors in patients with ankylosing spondylitis. Sundström, Björn; Johansson, Gunnar; Johansson, Ingegerd; Wållberg-Jonsson, Solveig // Clinical Rheumatology;Jan2014, Vol. 33 Issue 1, p111 

    The aim of this study was to evaluate whether modifiable cardiovascular disease (CVD) risk factors, e.g. atherogenic blood lipids, hypertension and lifestyle-related factors such as smoking, diet and physical inactivity, differ among patients with ankylosing spondylitis (AS) in comparison to the...

  • Metabolic syndrome in children. Sinaiko, Alan R. // Jornal de Pediatria;Jul/Aug2012, Vol. 88 Issue 4, p286 

    The article focuses on research into metabolic syndrome in children. It states that most cases of child obesity include low levels of high-density lipoprotein cholesterol and elevated triglycerides and comments on the infrequency of hypertension despite a high correlation with body mass index....

  • Association of von Willebrand factor blood levels with exercise hypertension. Nikolic, Sonja; Adams, Murray; Otahal, Petr; Edwards, Lindsay; Sharman, James // European Journal of Applied Physiology;May2015, Vol. 115 Issue 5, p1057 

    Purpose: A hypertensive response to moderate intensity exercise (HRE) is associated with increased cardiovascular risk. The mechanisms of an HRE are unclear, although previous studies suggest this may be due to haemostatic and/or haemodynamic factors. We investigated the relationships between an...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics